-
公开(公告)号：US5788662A
公开(公告)日：1998-08-04
申请号：US736862
申请日：1996-10-22
IPC分类号： A61K35/14 , A61L24/10 , A61M1/36 , B01D61/18 , B01D63/16 , B01D67/00 , B04B5/04 , C07K14/745 , A61K35/16 , B01D61/24
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , A61M1/3696 , B01D61/18 , B01D63/16 , B04B5/0442 , B01D2323/30 , B04B2005/0478
摘要： An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to stat preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
摘要翻译： 公开了一种具有用于制备组织密封剂的一次性盒的廉价装置。 该装置特别适用于自体组织密封胶的状态制备。 还公开了一种密封组织的方法，其中在将富含血小板的血浆浓缩物（来自该装置）与钙和凝血酶的溶液混合之后立即施加组织密封剂。 在手术室内从50cc患者血液制备5cc密封胶需要少于15分钟，只有一个简单的操作步骤。 没有跟踪错误的风险，因为可以在手术室进行处理。 加入的化学物质可能限于抗凝血剂（如柠檬酸盐）和氯化钙。 一次性药筒可以装配在手掌中并被密封，以消除患者血液的可能暴露并确保不育。 粘合剂和拉伸强度与用沉淀法制成的合并的血液纤维蛋白密封剂相当或优于其他。 抗纤维蛋白溶解剂（如抑肽酶）不是必需的，因为组织密封剂含有高浓度的患者血液中的纤维蛋白溶解天然抑制剂。 组织密封剂还含有患者血小板和不存在于促进伤口愈合的可用纤维蛋白密封剂中的另外的因素。
-
32.发明授权Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant 失效用于制备浓缩等离子体和/或组织密封剂的等离子体浓缩物和组织密封剂方法和装置
公开(公告)号：US5585007A
公开(公告)日：1996-12-17
申请号：US351010
申请日：1994-12-07
IPC分类号： A61K35/14 , A61L24/10 , A61M1/36 , B01D61/18 , B01D63/16 , B01D67/00 , B04B5/04 , C07K14/745 , B01D33/15 , A61K35/16 , A61M1/14 , B01D33/27
CPC分类号： B01D67/0093 , A61L24/106 , A61M1/3693 , A61M1/3696 , B01D61/18 , B01D63/16 , B04B5/0442 , B01D2323/30 , B04B2005/0478
摘要： An inexpensive device with a disposable cartridge for preparing tissue sealant is disclosed. The device is particularly applicable to star preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate (from the device) with a solution of calcium and thrombin is also disclosed. Preparation in the operating room of 5 cc sealant from 50 cc patient blood requires less than 15 minutes and only one simple operator step. There is no risk of tracking error because processing can be done in the operating room. Chemicals added may be limited to anticoagulant (e.g., citrate) and calcium chloride. The disposable cartridge may fit in the palm of the hand and is hermetically sealed to eliminate possible exposure to patient blood and ensure sterility. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents (such as aprotinin) are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibrin sealants that promote wound healing.
摘要翻译： 公开了一种具有用于制备组织密封剂的一次性盒的廉价装置。 该装置特别适用于自体组织密封剂的星形制剂。 还公开了一种密封组织的方法，其中在将富含血小板的血浆浓缩物（来自该装置）与钙和凝血酶的溶液混合之后立即施加组织密封剂。 在手术室内从50cc患者血液制备5cc密封胶需要少于15分钟，只有一个简单的操作步骤。 没有跟踪错误的风险，因为可以在手术室进行处理。 加入的化学物质可能限于抗凝血剂（如柠檬酸盐）和氯化钙。 一次性药筒可以装配在手掌中并被密封，以消除患者血液的可能暴露并确保不育。 粘合剂和拉伸强度与用沉淀法制成的合并的血液纤维蛋白密封剂相当或优于其他。 抗纤维蛋白溶解剂（如抑肽酶）不是必需的，因为组织密封剂含有高浓度的患者血液中的纤维蛋白溶解天然抑制剂。 组织密封剂还含有患者血小板和不存在于促进伤口愈合的可用纤维蛋白密封剂中的另外的因素。
-
公开(公告)号：US08474630B2
公开(公告)日：2013-07-02
申请号：US13480849
申请日：2012-05-25
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
-
公开(公告)号：US08328024B2
公开(公告)日：2012-12-11
申请号：US13198038
申请日：2011-08-04
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01L3/50215 , B01L2200/026
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。
-
公开(公告)号：US08187477B2
公开(公告)日：2012-05-29
申请号：US12951701
申请日：2010-11-22
申请人： Randel Dorian , Scott R. King , Richard W. Storrs
发明人： Randel Dorian , Scott R. King , Richard W. Storrs
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
-
36.发明授权Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权制备富血小板血浆及其浓缩物的装置及方法公开(公告)号：US08096422B2
公开(公告)日：2012-01-17
申请号：US12917055
申请日：2010-11-01
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D33/067 , B01D35/00 , B01D24/32 , B04B3/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.
摘要翻译： 公开了一种分离器收集器，例如用于分离和浓缩富血小板血浆（PRP），全血适用于办公用途或紧急用于创伤受害者。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离组件包括离心鼓分离器和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。
-
37.发明授权Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权制备富血小板血浆及其浓缩物的方法和装置公开(公告)号：US07987995B2
公开(公告)日：2011-08-02
申请号：US12772497
申请日：2010-05-03
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。
-
公开(公告)号：US20110021334A1
公开(公告)日：2011-01-27
申请号：US12897401
申请日：2010-10-04
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。
-
公开(公告)号：US07470371B2
公开(公告)日：2008-12-30
申请号：US11584414
申请日：2006-10-19
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 然后从血小板收集表面除去血小板。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
-
40.发明申请APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF 有权制备稀土等离子体及其浓度的装置和方法公开(公告)号：US20080011684A1
公开(公告)日：2008-01-17
申请号：US11831605
申请日：2007-07-31
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D35/00 , B01D24/32 , B01D33/067
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.
摘要翻译： 公开了一种富血小板血浆分离器组件。 组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。 底板，其具有向下倾斜到中心开口的上表面。 内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。 内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。 圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。
-
-
-
-
-
-
-
-
-
搜索结果
54 条记录 (耗时 0.033 秒)
