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公开(公告)号：US07223346B2
公开(公告)日：2007-05-29
申请号：US11108387
申请日：2005-04-18
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 然后从血小板收集表面除去血小板。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US07837884B2
公开(公告)日：2010-11-23
申请号：US12344895
申请日：2008-12-29
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US08474630B2
公开(公告)日：2013-07-02
申请号：US13480849
申请日：2012-05-25
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US07470371B2
公开(公告)日：2008-12-30
申请号：US11584414
申请日：2006-10-19
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 然后从血小板收集表面除去血小板。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US20160325039A1
公开(公告)日：2016-11-10
申请号：US15217635
申请日：2016-07-22
申请人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant Cunningham , Randel Dorian , Richard Wood Storrs , Scott R. King
发明人： Michael D. Leach , Ned M. Hamman , David Abeskaron , Grant Cunningham , Randel Dorian , Richard Wood Storrs , Scott R. King
CPC分类号： A61M1/3692 , A61M1/0281 , A61M1/3678 , A61M2202/0429 , A61M2205/3375 , B01D21/283 , B01L3/502761 , B01L9/527 , B01L2200/025 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/089 , B01L2400/0436 , C12M47/02 , C12N5/0641 , C12N13/00
摘要： Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can include a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface, an opposing second surface, a first side, and an opposing second side. The channel can extend along a longitudinal axis from a first end to an opposing second end. The first acoustic wave generator can be coupled to the first surface. The second acoustic wave propagating component can be coupled to the second surface. The first acoustic wave generator and second acoustic wave propagating component can be configured to generate a bulk standing acoustic wave in the channel.
摘要翻译： 公开了一种用于从多组分流体分离细胞组分的装置。 该装置可以包括主体，第一声波发生器和第二声波传播部件。 主体可以限定具有第一表面，相对的第二表面，第一侧和相对的第二侧的通道。 通道可以沿着纵向轴线从第一端延伸到相对的第二端。 第一声波发生器可以耦合到第一表面。 第二声波传播部件可以耦合到第二表面。 第一声波发生器和第二声波传播部件可以被配置为在通道中产生体声驻波。
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公开(公告)号：US20110065183A1
公开(公告)日：2011-03-17
申请号：US12951701
申请日：2010-11-22
IPC分类号： C12N5/078
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US20090101599A1
公开(公告)日：2009-04-23
申请号：US12344895
申请日：2008-12-29
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译： 一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。 空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。 浮游密度低于红细胞密度，高于血浆密度。 当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。 在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。 具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。
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公开(公告)号：US07553413B2
公开(公告)日：2009-06-30
申请号：US11342982
申请日：2006-01-30
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译： 本发明的等离子体浓缩器具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器。 搅拌器具有从下端向外延伸的搅拌器叶片。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 集中器具有顶部，其具有上部开口，致动器杆的上端延伸穿过该上部开口，以及下部开口，过滤器定位在该开口中。 浓缩器室可以具有圆柱形内壁，并且搅拌器叶片可以具有紧邻内壁的外边缘，外边缘和内壁之间的空间小于凝胶珠的直径。 选择过滤器以在环境重力条件下阻止等离子体的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 该方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 将等离子体引入含有多个脱水浓缩器凝胶珠和搅拌器的浓缩室中。 然后在搅拌珠子的同时从等离子体中除去水，以减少等离子极化并破坏在搅拌过程中形成的珠粒团块。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。
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公开(公告)号：US06905612B2
公开(公告)日：2005-06-14
申请号：US10394828
申请日：2003-03-21
申请人： Randel Dorian , Richard Wood Storrs
发明人： Randel Dorian , Richard Wood Storrs
CPC分类号： B01J20/28047 , B01D15/02 , B01J2220/64 , B01J2220/68 , B01L3/5635 , B01L2300/0681 , B01L2400/0478 , G01N1/40 , G01N1/405 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator for producing plasma concentrate from a plasma from which erythrocytes have been substantially removed. The device comprises a concentrating chamber having an inlet port and an concentrate outlet, the concentrating chamber containing hydrogel beads and at least one inert agitator; and a concentrate chamber having an inlet communicating with the concentrator outlet through a filter, and having an plasma concentrate outlet port. A process for producing plasma concentrate from plasma from which erythrocytes have been substantially removed, comprising the steps of a) moving the plasma into a concentrating chamber containing hydrogel beads and an agitator to form a hydrogel bead-plasma mixture; b) causing the agitator to stir the hydrogel bead-plasma mixture, facilitating absorption of water by the beads from the plasma, until a hydrogel bead-plasma concentrate is formed; and c) separating the plasma concentrate from the hydrogel beads by passing the plasma concentrate through a filter. The concentrator can be one or more syringe devices coupled for multiple concentrations.
摘要翻译： 用于从已经基本上除去红细胞的血浆中产生血浆浓缩物的血浆浓缩器。 该装置包括具有入口和浓缩物出口的浓缩室，该浓缩室含有水凝胶珠和至少一种惰性搅拌器; 以及浓缩物室，其具有通过过滤器与浓缩器出口连通并具有等离子体浓缩物出口的入口。 一种用于从已经基本上除去红细胞的血浆中产生血浆浓缩物的方法，包括以下步骤：a）将血浆移动到含有水凝胶珠和搅拌器的浓缩室中以形成水凝胶珠 - 等离子体混合物; b）使搅拌器搅拌水凝胶珠 - 等离子体混合物，促进珠粒从等离子体吸收水分，直到形成水凝胶珠 - 浆料浓缩物; 和c）通过使血浆浓缩物通过过滤器将血浆浓缩物与水凝胶珠分离。 浓缩器可以是连接多个浓度的一个或多个注射器装置。
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公开(公告)号：US20090236297A1
公开(公告)日：2009-09-24
申请号：US12476838
申请日：2009-06-02
IPC分类号： B01D33/27
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译： 具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。
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