Abstract:
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
Abstract:
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or more non-endogenous glycosylation sites.
Abstract:
A circuit for sensing load current of a voltage regulator. The circuit includes a power transistor and a mirror transistor. A first transistor sizing circuit is coupled to the power transistor and is operable to control size of the power transistor based on a bias voltage of the power transistor, thereby regulating a first voltage for varying load conditions. The circuit also includes a feedback amplifier coupled to the power transistor and the mirror transistor. A transistor is coupled to the feedback amplifier and the mirror transistor. An analog to digital converter (ADC) is coupled to the transistor. A second transistor sizing circuit is coupled to the mirror transistor, the transistor, and the ADC. The second transistor sizing circuit is responsive to an output voltage to control size of the mirror transistor, thereby ensuring that accuracy of output voltage sensed by ADC is not limited by ADC's resolution.
Abstract:
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
Abstract:
The invention provides targets coated with structured biological materials, which are employed in laser produced plasma systems. The biological materials selected from cells of microbial, protozoan or plankton origin are applied on a portion of a solid target, like polished glass plate which then form a target system that absorbs the intense laser pulses, generates hot dense plasma and results in the emission of the X-rays. The method of coating structured biomaterial decreases the usable laser intensity required for producing the hot plasma, while increasing the X-ray yield. The coatings are easy to prepare and it is possible to vary the nature and shape of the cellular material in order to control/regulate the interaction with the light and thereby optimize the resultant plasma generation and X-ray emission. The increase in temperature of the plasma and the increase in yield demonstrate that the method is suitable for enhancing the emission yield in the Ultra Violet, Extreme Ultra violet, x-ray and the hard x-ray regimes.
Abstract:
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Abstract:
Method and system for managing a storage environment having a cluster based storage system and a non-cluster based storage system is provided. A management application collects information regarding components of both the cluster based storage system and the non-cluster based storage system. A layout having a plurality of data structures is generated and maintained by the management application. The data structures include information regarding the components and their relationships with each other, if any. The layout is used for responding to user requests and presenting an integrated view of the storage environment on a display device with selectable options for selecting the cluster based storage system components and the non-cluster based storage system components.
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.