公开(公告)号：US5587378A

公开(公告)日：1996-12-24

申请号：US447885

申请日：1995-05-23

申请人： Fumio Suzuki ,  Junichi Shimada ,  Nobuaki Koike ,  Joji Nakamura ,  Shizuo Shiozaki ,  Shunji Ichikawa ,  Akio Ishii ,  Hiromi Nonaka

发明人： Fumio Suzuki ,  Junichi Shimada ,  Nobuaki Koike ,  Joji Nakamura ,  Shizuo Shiozaki ,  Shunji Ichikawa ,  Akio Ishii ,  Hiromi Nonaka

IPC分类号： C07D473/06 ,  C07D473/08 ,  C07D473/12 ,  A61K31/52

CPC分类号： C07D473/08 ,  C07D473/06 ,  C07D473/12

摘要： Methods for the treatment of Parkinson's disease comprising administering to a patient an agent which contains, as an active ingredient, a xanthine derivative or a pharmaceutically acceptable salt thereof. The xanthine derivative is represented by the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; and R.sup.4 is cycloalkyl, --(CH.sub.2).sub.n --R.sup.5, wherein R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4, or ##STR2## wherein Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen, or lower alkyl; and Z is substituted or unsubstituted aryl, ##STR3## wherein R.sup.6 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m is an integer of 1 to 4, or a substituted or unsubstituted heterocyclic group; and X.sup.1 and X.sup.2 are independently O or S.

摘要翻译： 用于治疗帕金森病的方法包括向患者施用含有作为活性成分的黄嘌呤衍生物或其药学上可接受的盐的试剂。 黄嘌呤衍生物由下式表示：其中R 1，R 2和R 3独立地是氢，低级烷基，低级链烯基或低级炔基; 并且R 4是环烷基， - （CH 2）n -R 5，其中R 5表示取代或未取代的芳基或取代或未取代的杂环基; n为0〜4的整数，或者，其中Y1和Y2独立地表示氢，卤素或低级烷基; Z是取代或未取代的芳基，其中R6是氢，羟基，低级烷基，低级烷氧基，卤素，硝基或氨基; m为1〜4的整数，或取代或未取代的杂环基; X1和X2独立地为O或S.

公开(公告)号：US5248684A

公开(公告)日：1993-09-28

申请号：US703849

申请日：1991-05-21

申请人： Fumio Suzuki ,  Hiroaki Hayashi ,  Yoshikazu Miwa ,  Akio Ishii ,  Shunji Ichikawa ,  Ichiro Miki

发明人： Fumio Suzuki ,  Hiroaki Hayashi ,  Yoshikazu Miwa ,  Akio Ishii ,  Shunji Ichikawa ,  Ichiro Miki

IPC分类号： A61K31/435 ,  A61K31/4375 ,  A61K31/46 ,  A61K31/47 ,  A61K31/4704 ,  A61P1/08 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07D451/04 ,  C07D451/12 ,  C07D451/14 ,  C07D519/00

CPC分类号： C07D451/04 ,  C07D451/12 ,  C07D451/14

摘要： There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US07938005B2

公开(公告)日：2011-05-10

申请号：US12607407

申请日：2009-10-28

申请人： Shunji Ichikawa

发明人： Shunji Ichikawa

IPC分类号： G01P15/08

CPC分类号： G01P1/023 ,  G01P15/123 ,  H01L2224/48091 ,  H01L2224/48465 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2924/10253 ,  H01L2924/1461 ,  H01L2924/00014 ,  H01L2924/00

摘要： An acceleration sensor chip package includes an acceleration sensor chip; a sensor control chip; a re-wiring layer; an outer terminal; a sealing portion; and a substrate. The acceleration sensor chip includes a frame portion; a movable structure; a detection element; and an electrode pad electrically. The re-wiring layer has a wiring portion connected to the electrode pad. The electrode pad is electrically connected to a conductive bump. The sensor control chip has a sensor control electrode pad electrically connected to the conductive bump. The outer terminal is connected to the wiring portion and disposed in the outer region. The sealing portion seals the sensor control chip, the electrode pad, and the re-wiring layer, so that the movable structure is movable. The substrate is attached to the acceleration sensor chip to seal an opening portion.

摘要翻译： 加速度传感器芯片封装包括加速度传感器芯片; 传感器控制芯片; 重新布线层; 外部终端; 密封部分; 和基材。 加速度传感器芯片包括框架部分; 可移动结构; 检测元件; 和电极垫。 再布线层具有连接到电极焊盘的布线部分。 电极焊盘电连接到导电凸块。 传感器控制芯片具有电连接到导电凸块的传感器控制电极焊盘。 外部端子连接到布线部分并且设置在外部区域中。 密封部密封传感器控制芯片，电极焊盘和再布线层，使得可移动结构是可移动的。 衬底附接到加速度传感器芯片以密封开口部分。

公开(公告)号：US5543415A

公开(公告)日：1996-08-06

申请号：US199142

申请日：1994-02-25

申请人： Fumio Suzuki ,  Junichi Shimada ,  Akio Ishii ,  Joji Nakamura ,  Shunji Ichikawa ,  Shigeto Kitamura ,  Nobuaki Koike

发明人： Fumio Suzuki ,  Junichi Shimada ,  Akio Ishii ,  Joji Nakamura ,  Shunji Ichikawa ,  Shigeto Kitamura ,  Nobuaki Koike

IPC分类号： F16B37/04 ,  A61K31/00 ,  A61K31/52 ,  B29C65/08 ,  B29C65/72 ,  C07D473/06 ,  C07D473/08 ,  C07D473/12 ,  C07D473/20 ,  C07D473/22 ,  A61K31/505

CPC分类号： A61K31/52 ,  C07D473/06 ,  C07D473/08 ,  F16B37/048

摘要： The present invention relates to an antidepressant containing as an active ingredient a xanthine derivative or a pharmaceutically acceptable salt thereof, the xanthine derivative being represented by Formula (I) : ##STR1## in which R.sup.1, R.sup.2, and R.sup.3 represent independently hydrogen, lower alkyl, lower alkenyl;R.sup.4 represents cycloalkyl, --(CH.sub.2).sub.n --R.sup.5 (in which R.sup.5 represents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; and n is an integer of 0 to 4), or ##STR2## (in which Y.sup.1 and Y.sup.2 represent independently hydrogen, halogen or lower alkyl; and Z represents substituted or unsubstituted aryl, ##STR3## (in which R.sup.6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or amino; and m represents an integer of 1 to 3), or a substituted or unsubstituted heterocyclic group);and X.sup.1 and X.sup.2 represent independently O or S.

摘要翻译： PCT No.PCT / JP93 / 00931 Sec。 371日期1994年2月25日 102（e）1994年2月25日PCT PCT 1993年7月7日PCT公布。 第WO94 / 01114号公报 日本时间1994年1月20日本发明涉及含有作为活性成分的黄嘌呤衍生物或其药学上可接受的盐的抗抑郁药，黄嘌呤衍生物由式（I）表示：其中R1，R2， 并且R 3独立地表示氢，低级烷基，低级烯基; R 4表示环烷基， - （CH 2）n -R 5（其中R 5表示取代或未取代的芳基或取代或未取代的杂环基; n为0〜4的整数）或

公开(公告)号：US4962107A

公开(公告)日：1990-10-09

申请号：US321692

申请日：1989-03-10

申请人： Joji Nakamura ,  Kazuhiro Kubo ,  Shunji Ichikawa ,  Hajime Takahashi ,  Keisuke Isozumi ,  Toyofumi Yamada

发明人： Joji Nakamura ,  Kazuhiro Kubo ,  Shunji Ichikawa ,  Hajime Takahashi ,  Keisuke Isozumi ,  Toyofumi Yamada

IPC分类号： A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61P25/28 ,  C07D211/16 ,  C07D211/22 ,  C07D211/46 ,  C07D265/30 ,  C07D265/32 ,  C07D279/12 ,  C07D295/18 ,  C07D295/185

CPC分类号： C07D265/30 ,  C07D211/16 ,  C07D211/22 ,  C07D279/12 ,  C07D295/185

摘要： Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.