公开(公告)号：US20210252114A1

公开(公告)日：2021-08-19

申请号：US17068999

申请日：2020-10-13

Applicant: Temple University of The Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: A61K38/46 ,  C12N15/11 ,  A61K48/00 ,  A61K9/00 ,  A61K35/12 ,  A61K45/06 ,  C12N7/00 ,  C12N9/22

Abstract: A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

公开(公告)号：US11077169B2

公开(公告)日：2021-08-03

申请号：US15746508

申请日：2016-07-21

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Peter I. Lelkes ,  Yah-El H. Har-el ,  Cezary Marcinkiewicz ,  Philip Lazarovici ,  Sogol Moaiyed Baharlou ,  Jonathan A. Gerstenhaber

IPC: A61L27/38 ,  A61L27/18 ,  A61F2/02 ,  A61K47/42 ,  A61K9/70 ,  A61K38/16 ,  A61L27/54 ,  A61L26/00 ,  A61L15/32 ,  A61L15/44 ,  A61L27/22 ,  A61L15/26 ,  A61P17/02 ,  A61L27/52

Abstract: Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.

公开(公告)号：US11065217B2

公开(公告)日：2021-07-20

申请号：US15903514

申请日：2018-02-23

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Ira C. Spector ,  Mark A. Feitelson ,  Alla Arzumanyan

IPC: A61K31/19 ,  A61K9/48 ,  A61K9/00 ,  A61K45/06 ,  A61P37/08 ,  A61P27/02 ,  A61P35/00 ,  A61P17/00

Abstract: The invention relates to compositions and methods that include short chain fatty acids (SCFAs), related therapeutic compounds, and other compounds, including combinations thereof, for the treatment or prevention of diseases or disorders.

公开(公告)号：US20210212994A1

公开(公告)日：2021-07-15

申请号：US16488250

申请日：2018-02-28

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： David B. Lebo ,  Cong Li

IPC: A61K31/4174 ,  A61K47/20 ,  A61K47/10 ,  A61K9/70 ,  A61K9/00

Abstract: The invention provides an econazole nitrate and thiourea medical patch for the treatment of nail and skin onychomycosis, achieving improved drug penetration, and thus allowing more drug to penetrate into the nail bed and reach the minimum inhibitory concentration.

公开(公告)号：US20210179807A1

公开(公告)日：2021-06-17

申请号：US16770825

申请日：2018-12-12

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Shenqiang Ren ,  Simona Percec ,  Zhuolei Zhang

IPC: C08K3/38 ,  C08F110/02 ,  C08J3/21 ,  B29B7/90 ,  B29C55/00 ,  B29C55/04 ,  B29C55/18 ,  B29C41/00 ,  F41H5/04

Abstract: A method of fabricating a polymer composite material by mixing a polymer material with a planar material, depositing the mixture on a substrate, and stretching the resulting thin film, is described. Polymer composite materials produced using said method and ballistic resistant materials comprising said polymer composite materials are also described.

公开(公告)号：US20210046030A1

公开(公告)日：2021-02-18

申请号：US16932236

申请日：2020-07-17

Applicant: Temple University - Of The Commonwealth System Of Higher Education

Inventor： Salim Merali ,  Carlos A. Barrero ,  Wayne e. Childers ,  George c. Morton

IPC: A61K31/198 ,  A61P3/08

Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.

公开(公告)号：US10898105B2

公开(公告)日：2021-01-26

申请号：US15614885

申请日：2017-06-06

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Samuel Alex Weprin ,  John Noel ,  Daniel D. Eun

IPC: A61B5/06 ,  G01V3/08 ,  A61B5/00 ,  G16H40/40 ,  G01V13/00 ,  G06F17/11

Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.

公开(公告)号：US20210017600A1

公开(公告)日：2021-01-21

申请号：US15929784

申请日：2020-05-21

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. Feldman ,  Douglas G. Tilley ,  Weizhong Zhu ,  Kamel Khalili ,  Walter J. Koch

IPC: C12Q1/6883 ,  G01N33/68

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

公开(公告)号：US20200375949A1

公开(公告)日：2020-12-03

申请号：US16766419

申请日：2018-11-21

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  EMORY UNIVERSITY

Inventor： Marisa C. KOZLOWSKI ,  Young Eun LEE ,  Thomas PANIAK ,  Cristian OCHOA ,  William M. WUEST ,  Amy E. SOLINSKI

IPC: A61K31/415 ,  A61K31/047 ,  A61K31/09 ,  A61K31/137 ,  A61K31/165 ,  A61K8/49 ,  A61K8/34 ,  A61K8/42 ,  A61K8/41

Abstract: The present disclosure provides compounds of formula (I) or salts thereof, wherein R1-R10 and x are defined herein; compositions containing these compounds; methods of inhibiting, reducing, or ameliorating bacterial growth on a substrate using these compound; and products such as dental care products, soaps, antibacterial products, and plastics comprise one or more compounds described herein.

公开(公告)号：US10814089B2

公开(公告)日：2020-10-27

申请号：US16094574

申请日：2017-04-18

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Marla Wolfson ,  Thomas Shaffer

IPC: A61M16/08 ,  A61M16/20 ,  A61M16/16 ,  A61M16/00

Abstract: The present invention provides a respiratory adapter for inhaled media deposition in the lungs and airways. The respiratory adapter provides an inspiratory arm and an expiratory arm, wherein the two arms are joined by a bypass flow bridge. A system of valves, such as one-way valves, directs the flow of gas and media through the respiratory adapter to improve media deposition efficiency and to prevent re-breathing of exhaled gas.