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31.发明申请CARBOXYALKOXY-SUBSTITUTED ACYL-CARBOXYPHENYLUREA DERIVATIVES AND THEIR USE AS MEDICAMENTS 有权羧氧基取代的乙酰氧基苯甲醛衍生物及其作为药物的用途公开(公告)号：US20070088083A1
公开(公告)日：2007-04-19
申请号：US11613433
申请日：2006-12-20
Applicant: Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
Inventor： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC: A61K31/277 , A61K31/24 , A61K31/195 , C07C275/46
CPC classification number: C07C275/54
Abstract: The invention relates to acyl-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I, in which the radicals have the stated meanings, and the physiological tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example for the treatment of type II diabetes.
Abstract translation: 本发明涉及酰基羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理耐受盐及其制备方法。 该化合物适用于例如治疗II型糖尿病。
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32.发明授权Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use 有权羰基氨基取代的酰基苯基脲衍生物，其制备方法及其应用公开(公告)号：US07179941B2
公开(公告)日：2007-02-20
申请号：US10763877
申请日：2004-01-23
Applicant: Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
Inventor： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC: C07C273/00 , C07C53/00 , C07C59/00 , C07C229/00 , A61K31/00
CPC classification number: C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
Abstract: The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
Abstract translation: 本发明涉及式Ⅰ化合物，其中基团按照规定定义，也涉及其生理上耐受的盐。 该化合物例如可用作预防和治疗2型糖尿病的药物。
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33.发明申请Heterocyclically Substituted Benzoylureas, Process For Their Preparation and Their Use as Pharmaceuticals 审中-公开杂环取代苯甲酰脲，其制备方法及其作为药物的用途公开(公告)号：US20070021474A1
公开(公告)日：2007-01-25
申请号：US11464907
申请日：2006-08-16
Applicant: Karl Schoenafinger , Elisabeth DeFossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
Inventor： Karl Schoenafinger , Elisabeth DeFossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
IPC: A61K31/44 , A61K31/40 , A61K31/277 , A61K31/195 , A61K31/17 , C07C275/40
CPC classification number: C07D211/60 , C07D211/62 , C07D231/12 , C07D231/26 , C07D233/56 , C07D235/18 , C07D249/08 , C07D249/12 , C07D253/07 , C07D257/04 , C07D271/10 , C07D271/113 , C07D307/68
Abstract: Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives. Compounds are described of the formula I where the radicals are defined as specified, and also their pharmaceutically acceptable salts and processes for their preparation. The compounds are suitable, for example, for treating type 2 diabetes.
Abstract translation: 杂环取代的苯甲酰脲，其制备方法及其作为药物的用途本发明涉及杂环取代的苯甲酰脲以及其生理上耐受的盐和生理功能衍生物。 化合物描述为其中基团被定义为特定的式I，以及它们的药学上可接受的盐及其制备方法。 该化合物适用于例如治疗2型糖尿病。
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34.发明授权N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use 有权N-苯甲酰基肉豆蔻酸衍生物，其制备方法及其应用公开(公告)号：US07049341B2
公开(公告)日：2006-05-23
申请号：US10456570
申请日：2003-06-06
Applicant: Karl Schoenafinger , Elisabeth Defossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
Inventor： Karl Schoenafinger , Elisabeth Defossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
IPC: A61K31/24 , A61K31/195 , C07C229/00 , C07C275/00
CPC classification number: C07C275/54
Abstract: N-Benzoylureidocinnamic acid derivatives, processes for preparing them and their useThe invention relates to N-benzoylureidocinnamic acid derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention thus relates to compounds of formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetic agents.
Abstract translation: N-苯甲酰脲基肉桂酸衍生物，其制备方法及其用途本发明涉及N-苯甲酰脲基肉桂酸衍生物及其生理上耐受的盐和生理功能衍生物。 因此，本发明涉及其中基团具有给定含义的式I化合物及其生理上耐受的盐及其制备方法。 化合物例如适合用作抗糖尿病药。
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35.发明申请Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments 有权杂环取代的7-氨基-4-喹诺酮-3-羧酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20050182086A1
公开(公告)日：2005-08-18
申请号：US11042589
申请日：2005-01-25
Applicant: Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
Inventor： Elisabeth Defossa , Dieter Kadereit , Sven Ruf , Thomas Klabunde , Dieter Schmoll , Andreas Herling , Karl-Ulrich Wendt
IPC: A61K31/4709 , A61K31/4745 , C07D471/02 , C07D41/02 , C07D43/02
CPC classification number: C07D215/56 , C07D401/12 , C07D417/12 , C07D471/04
Abstract: The invention relates to heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
Abstract translation: 本发明涉及杂环取代的7-氨基-4-喹诺酮-3-羧酸衍生物及其生理上耐受的盐和生理功能衍生物。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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Patent Agency Ranking
![3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT](/abs-image/US/2013/07/04/US20130172248A1/abs.jpg.150x150.jpg)
36.发明申请3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 审中-公开3- [4-（苯甲酰氨基氨基）苯基]十六烷基-4-氨基酸，其制备方法和用作药物公开(公告)号：US20130172248A1
公开(公告)日：2013-07-04
申请号：US13734413
申请日：2013-01-04
Applicant: Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
Inventor： Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
IPC: C07C233/56 , A61K38/28 , C07C231/02 , C07C229/42 , A61K31/196 , A61K45/06
CPC classification number: C07C233/56 , A61K31/196 , A61K38/28 , A61K45/06 , C07C229/42 , C07C231/02 , A61K2300/00
Abstract: The invention relates to 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3 and R4 are each defined as specified, and to physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
Abstract translation: 本发明涉及3- [4-（苯基氨基草酰氨基）苯基]己-4-炔酸，以及其生理上相容的盐。 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3和R 4各自定义和其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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37.发明申请(2-ARYLOXYACETYLAMINO) PHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS 有权（2-ARYLOXYACETYLAMINO）苯丙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004167A1
公开(公告)日：2012-01-05
申请号：US13176503
申请日：2011-07-05
Applicant: Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
Inventor： Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC: A61K31/197 , C07C255/43 , A61P3/10 , A61K38/28 , A61K38/27 , A61K31/702 , A61K31/40 , A61K31/403 , A61K31/472 , A61K31/4439 , A61K38/17 , A61K31/4985 , A61K31/451 , A61P3/08 , C07C229/42
CPC classification number: C07C235/24 , C07C255/44
Abstract: The invention relates to substituted (2-aryloxyacetylamino)phenylpropionic acid derivatives, and to the physiologically acceptable salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and A are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
Abstract translation: 本发明涉及取代的（2-芳氧基乙酰基氨基）苯基丙酸衍生物及其生理上可接受的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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38.发明申请ARYLOXYALKYLENE-SUBSTITUTED HYDROXYPHENYLHEXYNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 审中-公开芳基亚甲基取代的羟基苯甲酸，其制备方法和用作药物公开(公告)号：US20120004166A1
公开(公告)日：2012-01-05
申请号：US13176417
申请日：2011-07-05
Applicant: Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
Inventor： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC: A61K31/192 , C07D213/65 , A61K31/44 , C07C255/57 , A61K31/277 , A61P3/10 , A61K38/28 , A61K38/27 , A61K31/702 , A61K31/40 , A61K31/403 , A61K31/472 , A61K31/4439 , A61K38/17 , A61K31/4985 , A61K31/451 , A61P3/08 , C07C59/68
CPC classification number: C07C255/54 , C07B2200/07 , C07C59/64 , C07C2601/02 , C07D213/65
Abstract: The invention relates to aryloxyalkylene-substituted hydroxyphenylhexynoic acid derivatives, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14 and A are each defined as specified, and physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
Abstract translation: 本发明涉及芳氧基亚烷基取代的羟基苯基炔诺酸衍生物及其生理上相容的盐。 本发明涉及式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14和A各自定义如上， 其中。 该化合物适用于例如治疗糖尿病。
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39.发明申请Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof 审中-公开新的苯基取代的咪唑啉，其制备方法，包含所述化合物的药物及其用途公开(公告)号：US20110178134A1
公开(公告)日：2011-07-21
申请号：US12852038
申请日：2010-08-06
Applicant: Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
Inventor： Gerhard JAEHNE , Siegfried STENGELIN , Matthias GOSSEL , Thomas KLABUNDE , Irvin WINKLER , Antony BIGOT , Anita DIU-HERCEND , Gilles TIRABOSCHI
IPC: A61K31/4439 , C07D233/02 , C07D401/06 , A61K31/4166 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/32 , A61P25/34 , A61P25/18
CPC classification number: C07D233/72 , C07D401/06
Abstract: The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
Abstract translation: 本发明涉及其中基团具有所述含义的式（I）化合物及其生理上相容的盐。 所述化合物例如适合作为抗肥胖药物和治疗心脏代谢综合征。
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40.发明授权Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments 有权羧甲氧基取代的酰基 - 羧基苯基脲衍生物及其作为药物的用途公开(公告)号：US07781459B2
公开(公告)日：2010-08-24
申请号：US11613433
申请日：2006-12-20
Applicant: Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
Inventor： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC: A61K31/445 , C07D211/08
CPC classification number: C07C275/54
Abstract: The invention relates to acyl-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.Compounds of the formula I, in which the radicals have the stated meanings, and the physiological tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example for the treatment of type II diabetes.
Abstract translation: 本发明涉及酰基羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理耐受盐及其制备方法。 该化合物适用于例如治疗II型糖尿病。
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