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公开(公告)号：US20240190992A1
公开(公告)日：2024-06-13
申请号：US18285632
申请日：2022-04-04
发明人： Taro TACHIBANA , Kanichiro IHARA , Yuichi HORI , Kazuya SHIMIZU
IPC分类号： C07K16/30 , A61P35/00 , C07K16/18 , G01N33/574 , A61K39/00
CPC分类号： C07K16/303 , A61P35/00 , C07K16/18 , C07K16/30 , G01N33/57438 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/732 , G01N2333/70596
摘要： The purpose of the present invention is to provide an antibody against pancreatic cancer stem cells. This antibody against pancreatic cancer stem cells includes a heavy chain variable region including heavy chain CDRs described as HCDR1-HCDR3, and a light chain variable region including light chain CDRs described as LCDR1-LCDR3, and has an ability to bind to pancreatic cancer stem cells, where HCDR1 has an amino acid sequence located at positions 26-35 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR2 has a sequence located at positions 47-65 in SEQ ID NO: 1 or a sequence analogous thereto, HCDR3 has a sequence located at positions 96-104 in SEQ ID NO: 1 or a sequence analogous thereto, LCDR1 has a sequence located at positions 24-34 in SEQ ID NO: 2 or a sequence analogous thereto, LCDR2 has a sequence located at positions 46-56 in SEQ ID NO: 2 or a sequence analogous thereto, and LCDR3 has a sequence located at positions 89-96 in SEQ ID NO: 2 or a sequence analogous thereto.
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公开(公告)号：US11977007B2
公开(公告)日：2024-05-07
申请号：US17264868
申请日：2020-05-01
发明人： Masato Takeuchi , Junpei Furuno , Kenta Fukui , Kenichi Yoshioka , Tatsuya Tanihira , Masakazu Sai , Takafumi Taniguchi , Hirokazu Mitsuhashi
CPC分类号： G01N1/2205 , B01D53/0407 , B01J20/22 , B01J20/28064 , B01J20/28073 , B01J20/28076 , G01N27/16
摘要： Siloxane compounds are removed from the atmospheres by silica supporting an organic sulfonic acid compound. The silica with the organic sulfonic acid compound has a specific surface area down to 500 m2/g and up to 750 m2/g and a pore volume down to 0.8 m3/g and up to 1.2 m3/g, both measured by nitrogen gas adsorption method and has a pore diameter down to 4 nm and up to 8 nm, at the peak of differential pore volume measured by nitrogen gas adsorption method. The durability of gas sensing element against siloxanes is improved.
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公开(公告)号：US20240089422A1
公开(公告)日：2024-03-14
申请号：US18271115
申请日：2022-01-06
发明人： Kaoru KUSAFUKA , Hideya TAKAHASHI , Goro HAMAGISHI
IPC分类号： H04N13/317 , H04N13/194 , H04N13/31 , H04N13/383
CPC分类号： H04N13/317 , H04N13/194 , H04N13/31 , H04N13/383
摘要： A three-dimensional display device includes a display panel that emits image light, a barrier panel overlapping the display panel in an optical path of the image light and including multiple shutter cells (S) switchable between a transmissive portion and a light-blocking portion, a position detector that detects a position of at least one of a first eye or a second eye of a viewer, and a controller that controls the display panel and the barrier panel. The controller calculates a cumulative error between a barrier pitch (Bp) and an image pitch (k) corresponding to positions of the first and second eyes of the viewer based on position detection information from the position detector, and controls, when a ratio of the calculated cumulative error to one dot is greater than a first ratio, the image pitch (k) to be greater by at least one dot to reduce the cumulative error.
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公开(公告)号：US11884905B2
公开(公告)日：2024-01-30
申请号：US16484506
申请日：2018-01-18
发明人： Masaya Hagiwara
摘要： The present invention provides a fluidic chip for cell culture use which can prevent a decrease in the activity of cultured cells in a preparation stage, and which makes it possible to observe a cultured cell tissue while detaching the cultured cell tissue from the fluidic chip. The fluidic chip according to the present invention is characterized by being provided with a base and a lid member, wherein the base and the lid member are configured in such a manner that a first flow path and a first accommodation section for attachably/detachably accommodating a first culture vessel are formed between the base and the lid member when the base and the lid member are bonded to each other, the first culture vessel encloses a culture gel into which cells or a cell tissue is to be embedded and is at least partially formed from a hydrogel or a porous body, and the base and the lid member are configured in such a manner that at least a portion of a culture solution flowing through the first flow path is supplied to the first accommodation section.
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公开(公告)号：US11774445B2
公开(公告)日：2023-10-03
申请号：US16614112
申请日：2018-05-17
发明人： Yan Xu
IPC分类号： B01L3/00 , G01N33/543 , G01N33/536 , C12M1/34 , G01N15/14 , G01N1/10 , G01N15/00
CPC分类号： G01N33/54346 , B01L3/502761 , C12M1/34 , G01N15/1484 , G01N33/536 , B01L2200/0668 , B01L2300/0864 , B01L2300/0896 , G01N1/10 , G01N2015/0038 , G01N2015/0065
摘要： The particle trapping device according to the present invention comprises: a lead-in channel; a flattened channel disposed on the downstream side of the lead-in channel; a rectangular channel disposed on the downstream side of the flattened channel; and a particle pit trap disposed at least on a first inner wall face of the rectangular channel, wherein the lead-in channel has a channel cross-section larger than a channel cross-section of the flattened channel; the flattened channel has a flat channel cross-section whose the width is longer than its height; the rectangular channel has a rectangular channel cross-section, and is provided with the first inner wall face, a second inner wall face opposed to the first inner wall face, a third inner wall face, and a fourth inner wall face opposed to the third inner wall face; and the lead-in channel, the flattened channel, the rectangular channel, and the particle pit trap are characterized by being configured in such a way that a portion of liquid containing target particles and flowing through the lead-in channel flows into the flattened channel; the target particles contained in the liquid that had flowed through the flattened channel flow into the rectangular channel; and the target particle that had flowed through the rectangular channel enters into the particle pit trap and is trapped therein.
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公开(公告)号：US11773904B2
公开(公告)日：2023-10-03
申请号：US17607372
申请日：2020-04-10
IPC分类号： F16C19/06 , F16C33/58 , F16C33/62 , F16C33/64 , C22C32/00 , F16C35/063 , B23K26/342
CPC分类号： F16C33/64 , C22C32/0047 , F16C19/06 , F16C33/62 , F16C35/063 , B23K26/342 , F16C33/585 , F16C2204/52
摘要： A ball bearing has an outer circumferential surface of an inner ring subjected to a surface treatment by laser cladding in a circumferential direction, forming an annular first build-up layer with which a plurality of balls 4 is brought into contact so that the balls are rolled in the circumferential direction (first build-up layer formation step). An inner circumferential surface of an outer ring is subjected to a surface treatment by laser cladding in a circumferential direction, thereby forming an annular second build-up layer with which the plurality of balls contacts so that the balls can be rolled in the circumferential direction (second build-up layer formation step).
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公开(公告)号：US20230194413A1
公开(公告)日：2023-06-22
申请号：US17921420
申请日：2021-05-07
CPC分类号： G01N21/171 , G01N21/6456 , G01N2201/06113 , G01N33/582
摘要： A microscopic object detection system includes a collecting kit and a detection device. The collecting kit has a thin film for converting light into heat and is configured to be capable of holding a sample on the thin film. The detection device detects a plurality of microscopic objects in the sample by collecting the plurality of microscopic objects dispersed in the sample with the collecting kit. The detection device includes a laser module, an optical receiver, and a controller. The laser module emits a laser beam with which the collecting kit is irradiated. The optical receiver detects the laser beam from the sample held by the collecting kit and outputs a detection signal thereof. The controller calculates an amount of the plurality of microscopic objects collected in the sample based on a change of the detection signal over time.
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公开(公告)号：US20230069592A1
公开(公告)日：2023-03-02
申请号：US17953545
申请日：2022-09-27
IPC分类号： C07C67/347 , B01J31/18 , C07C37/62 , C07C67/343
摘要： An object of the present invention is to provide a novel method for producing a fluorine-containing methylene compound.
The above object can be achieved by a method for producing a compound represented by formula (1): wherein R1 represents an organic group, RA represents hydrogen or fluorine, R4a represents hydrogen or an organic group, R4b represents hydrogen or an organic group, R5a represents hydrogen or an organic group, R5b represents hydrogen or an organic group, and R2 represents hydrogen or an organic group; R2 is optionally connected to R4a to form a ring; the method comprising step A of reacting a compound represented by formula (2): wherein X1 represents a leaving group, and other symbols are as defined above, with a compound represented by formula (3): wherein X2 represents a leaving group, and other symbols are as defined above, in the presence of a reducing agent as desired, under light irradiation.-
39.发明申请公开(公告)号：US20230042928A1
公开(公告)日：2023-02-09
申请号：US17767732
申请日：2020-10-09
摘要： An object is to provide an electrode active material that can provide an alkali metal battery having a longer charge/discharge life and a higher capacity. The problem is solved by means of an electrode active material for an alkali metal battery, represented by formula: Aa1MSa2Xa3 wherein A is selected from Li and Na; M is selected from V, Nb, Ta, Ti, Zr, Hf, Cr, Mo, and W which are group 4 to 6 elements; X is selected from F, Cl, Br, I, CO3, SO4, NO3, BH4, BF4, PF6, ClO4, CF3SO3, (CF3SO2)2N, (C2F5SO2)2N, (FSO2)2N, and [B(C2O4)2]; a1 is 1 to 9; a2 is 2 to 6; when a3 is 3 and a3 is 0, a2 is not 4; and when M does not include V, a3>0.
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40.发明申请公开(公告)号：US20220275357A1
公开(公告)日：2022-09-01
申请号：US17612613
申请日：2020-05-19
发明人： Takashi INUI
IPC分类号： C12N9/90 , A61K9/19 , A61K9/50 , A61K31/4745 , A23L33/17
摘要： There has been an idea to load a pharmaceutical agent in a barrel structure of a lipocalin-type prostaglandin D synthase, and to seal the pharmaceutical agent in the barrel structure by introducing a disulfide bond between H2-helix and E-F loop.
However, in some cases the pharmaceutical agent is released through a gap in the vicinity of the open mouth of the barrel structure.
The present capsule protein has substitution of alanine residue for a cysteine residue of the active center of the human lipocalin-type prostaglandin D synthetase. The protein further has substitution of barrier amino acid residue(s) for at least one amino acids of D strand. The barrier amino acids in the D-strand, located in the vicinity of the open mouth of its barrel structure suppresses the leak of the pharmaceutical agent.
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