公开(公告)号：US20130040992A1

公开(公告)日：2013-02-14

申请号：US13584722

申请日：2012-08-13

Applicant: Ulrich Rosentreter ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

Inventor： Ulrich Rosentreter ,  Thomas Krämer ,  Andrea Vaupel ,  Walter Hübsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

IPC: A61K31/444 ,  A61K31/4418 ,  C07D401/12 ,  A61K31/4439 ,  C07D409/12 ,  A61K31/4436 ,  A61K31/443 ,  C07D405/14 ,  C07D417/14 ,  A61P9/00 ,  A61P9/12 ,  A61P9/06 ,  A61P9/10 ,  A61P25/00 ,  C07D213/85

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/14

Abstract: The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.

Abstract translation: 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。

公开(公告)号：US08242281B2

公开(公告)日：2012-08-14

申请号：US11607262

申请日：2006-12-01

Applicant: Ulrich Rosentreter ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

Inventor： Ulrich Rosentreter ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

IPC: C07D213/72 ,  C07D213/00 ,  A01N43/40

CPC classification number: C07D401/12 ,  C07D213/85 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/14

Abstract: The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.

Abstract translation: 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。

公开(公告)号：US20100003709A1

公开(公告)日：2010-01-07

申请号：US11793367

申请日：2005-12-13

Applicant: Peter Reinemer ,  Heike Gielen-Haertwig ,  Ulrich Rosentreter ,  Volkhart Li ,  Axel Harrenga ,  Dietmar Schomburg ,  Karsten Niefind ,  Guido Hansen

Inventor： Peter Reinemer ,  Heike Gielen-Haertwig ,  Ulrich Rosentreter ,  Volkhart Li ,  Axel Harrenga ,  Dietmar Schomburg ,  Karsten Niefind ,  Guido Hansen

IPC: C12Q1/37 ,  C12N9/66 ,  G06G7/48 ,  C07D239/22

CPC classification number: C07D239/36 ,  C07K2299/00 ,  C12N9/6448 ,  C12Y304/21037

Abstract: This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.

Abstract translation: 本发明涉及结晶人嗜中性粒细胞弹性蛋白酶及其三维结构用于设计人嗜中性粒细胞弹性蛋白酶调节剂的用途。

公开(公告)号：US20080249133A1

公开(公告)日：2008-10-09

申请号：US11631755

申请日：2005-06-23

Applicant: Thomas Krahn ,  Wolfgang Thielemann ,  Ulrich Rosentreter ,  Nicole Diedrichs ,  Thomas Kramer

Inventor： Thomas Krahn ,  Wolfgang Thielemann ,  Ulrich Rosentreter ,  Nicole Diedrichs ,  Thomas Kramer

IPC: A61K31/444 ,  A61K31/44 ,  A61K31/4436 ,  A61P1/08

CPC classification number: A61K31/4427

Abstract: The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) for production of a medicament for the prophylaxis and/or treatment of nausea and vomiting.

Abstract translation: 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基 - 吡啶在制备用于预防和/或治疗恶心和呕吐的药物中的用途 。

公开(公告)号：US20080176859A1

公开(公告)日：2008-07-24

申请号：US11894307

申请日：2007-08-20

Applicant: Holger ZIMMERMANN ,  David BRUECKENER ,  Kerstin HENNINGER ,  Ulrich ROSENTRETER ,  Martin HENDRIX ,  Joerg KELDENICH ,  Dieter LANG ,  Martin RADTKE ,  Daniela PAULSEN ,  Armin KERN

Inventor： Holger ZIMMERMANN ,  David BRUECKENER ,  Kerstin HENNINGER ,  Ulrich ROSENTRETER ,  Martin HENDRIX ,  Joerg KELDENICH ,  Dieter LANG ,  Martin RADTKE ,  Daniela PAULSEN ,  Armin KERN

IPC: A61K31/496 ,  C07D233/54 ,  A61K31/4164 ,  C07D401/14 ,  C07D401/04

CPC classification number: C07D233/90 ,  C07D401/12

Abstract: The invention relates to heterocyclylamide-substituted imidazoles and methods for their preparation, their use for the treatment and/or prophylaxis of diseases as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the use as antiviral agents, especially against cytomegaloviruses.

Abstract translation: 本发明涉及杂环基酰胺取代的咪唑及其制备方法，它们用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 作为抗病毒剂，特别是针对巨细胞病毒。

公开(公告)号：US07230017B2

公开(公告)日：2007-06-12

申请号：US10525608

申请日：2003-08-18

Applicant: Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Min-Jian Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemmer ,  Swen Allerheiligen ,  Leila Telan ,  Lars Bärfacker ,  Jörg Keldenich ,  Mary F. Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A61K31/4412 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/4545 ,  C07D401/02 ,  C07D413/02 ,  C07D211/86 ,  C07D213/22 ,  C07D417/02

CPC classification number: C07D401/04 ,  C07D211/90 ,  C07D405/04 ,  C07F7/1804

Abstract: The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

Abstract translation: 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。

公开(公告)号：US20060111377A1

公开(公告)日：2006-05-25

申请号：US10527386

申请日：2003-08-28

Applicant: Heike Gielen-Haertwig ,  Volkhart Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemer ,  Swen Sllerheiligen ,  Leila Telan ,  Lars Barfacker ,  Jorg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

Inventor： Heike Gielen-Haertwig ,  Volkhart Li ,  Ulrich Rosentreter ,  Karl-Heinz Schlemer ,  Swen Sllerheiligen ,  Leila Telan ,  Lars Barfacker ,  Jorg Keldenich ,  Mary Fitzgerald ,  Kevin Nash ,  Barbara Albrecht ,  Dirk Meurer

IPC: A61K31/513 ,  C07D403/04 ,  C07D239/32

CPC classification number: C07D239/22 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.

Abstract translation: 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。

公开(公告)号：US07045631B2

公开(公告)日：2006-05-16

申请号：US10484133

申请日：2002-07-03

Applicant: Ulrich Rosentreter ,  Thomas Kramer ,  Mitsuyuki Shimada ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch

Inventor： Ulrich Rosentreter ,  Thomas Kramer ,  Mitsuyuki Shimada ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Kerstin Henninger ,  Johannes-Peter Stasch

IPC: C07D213/62 ,  C07D417/12

CPC classification number: C07D417/12 ,  C07D213/85

Abstract: Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.

Abstract translation: 描述了式（I）化合物的制备方法及其作为药物的用途。

公开(公告)号：US20050261502A1

公开(公告)日：2005-11-24

申请号：US10469556

申请日：2002-02-20

Applicant: Ulrich Rosentreter ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

Inventor： Ulrich Rosentreter ,  Thomas Kramer ,  Andrea Vaupel ,  Walter Hubsch ,  Nicole Diedrichs ,  Thomas Krahn ,  Klaus Dembowsky ,  Johannes-Peter Stasch

IPC: A61K31/44 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/10 ,  A61P15/10 ,  A61P17/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D213/85 ,  C07D405/04 ,  C07D409/14 ,  C07D417/14 ,  C07D213/84

CPC classification number: C07D405/04 ,  C07D213/85 ,  C07D409/14 ,  C07D417/14

Abstract: The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.

Abstract translation: 公开了使用式（I）化合物作为药物，新的式（I）化合物及其制备方法。 式（I）化合物作为腺苷受体配体是有效的。

公开(公告)号：US5374647A

公开(公告)日：1994-12-20

申请号：US42857

申请日：1993-04-05

Applicant: Horst Bohagen ,  Ulrich Muller ,  Ulrich Rosentreter ,  Erwin Bischoff ,  Volker-Bernd Fiedler ,  Elisabeth Perzborn ,  Joachim Hutter ,  Peter Norman ,  Nigel J. Cuthbert ,  Hilary P. Francis ,  Marie G. McKenniff

Inventor： Horst Bohagen ,  Ulrich Muller ,  Ulrich Rosentreter ,  Erwin Bischoff ,  Volker-Bernd Fiedler ,  Elisabeth Perzborn ,  Joachim Hutter ,  Peter Norman ,  Nigel J. Cuthbert ,  Hilary P. Francis ,  Marie G. McKenniff

IPC: C07D209/86 ,  A61K31/40 ,  A61K31/403 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P37/08 ,  C07D209/88 ,  C07D209/94

CPC classification number: C07D209/88

Abstract: Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.

Abstract translation: 取代的抗血栓形成取代的环烷基[b]二氢吲哚 - 和吲哚磺酰胺，用于治疗其他基团的血栓形成，血栓栓塞，局部缺血，哮喘和过敏，X是芳基，烷基或CF 3，m和Z各自为1 ，2,3或4，n为0,1或2，A为键或-NH-，Y为OH，烷氧基，芳氧基，氨基或磺酰胺，条件是在所有情况下，两个取代基 在m表示数2，Y表示羟基的情况下，R 1 -R 4不是氢，或其盐。