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    MAMC-MEDIATED BIOMIMETIC NANOPARTICLES
    36.
    发明申请
    MAMC-MEDIATED BIOMIMETIC NANOPARTICLES 有权

    公开(公告)号：US20220143212A1

    公开(公告)日：2022-05-12

    申请号：US17290522

    申请日：2019-11-04

    申请人： UNIVERSIDAD DE GRANADA

    发明人： Concepción JIMÉNEZ LÓPEZ ,  Carmen VALVERDE TERCEDOR ,  Ana PEIGNEUX NAVARRO ,  Ylenia María JABALERA RUZ ,  María PRAT ,  Francesca OLTOLINA

    IPC分类号： A61K47/69 ,  A61K9/127 ,  C07K14/195 ,  A61K41/00 ,  A61K31/704

    摘要： Biomimetic magnetic nanoparticles comprising MamC. The present invention provides superparamagnetic biomimetic nanoparticles comprising magnetite, which can be produced using a scalable process. In addition, these nanoparticles exhibit promising properties, since, if functionalized, they can be converted into drug carriers or contrast agents for obtaining clinical images. They can also be used in clinical setting to purge bone marrow, as molecule separators, and/or for environmental applications as biosensors. These nanoparticles, coupled to a drug, can be encapsulated in liposomes, thereby obtaining magnetoliposomes, which can be functionalized for use in the targeted delivery/release of drugs. In addition, mixtures of magnetoliposomes (functionalized or not with a targeting agent) and functionalized biomimetic magnetic nanoparticles or liposomes containing mixtures of functionalized BMNPs and MNPs can be used to combine different treatments, such as, for example, targeted delivery/release of drugs and hyperthermia.

    WEAR OR PROTECTION SYSTEM FOR A TOOL OF A MACHINE FOR MOVING EARTH AND CORRESPONDING PIN
    38.
    发明申请
    WEAR OR PROTECTION SYSTEM FOR A TOOL OF A MACHINE FOR MOVING EARTH AND CORRESPONDING PIN 有权

    公开(公告)号：US20210277631A1

    公开(公告)日：2021-09-09

    申请号：US16313976

    申请日：2018-07-13

    申请人： METALOGENIA RESEARCH & TECHNOLOGIES S.L. ,  UNIVERSIDAD DE GRANADA

    发明人： JORDI MARQUEZ LLINAS ,  EDUARD ALVAREZ PORTELLA ,  JORGE TRIGINER BOIXEDA ,  JOAN TUTO FAJA

    IPC分类号： E02F9/28

    摘要： The invention relates to a wear or protection system for a tool of an earth moving machine, comprising a wear element (1), a support (3) and a pin (7) with elastic means (13) housed in a housing (5) having a base surface (27) and a compression surface (29). The base surface (27) and a first portion (31) of the compression surface (29) belong to the wear element (1), and the distance between both has a fixed value Df. A second portion (33) of the compression surface (29) belongs to the support (3), and the distance between the base surface (27) and the second portion (33) is variable depending on the wear of the system, having a minimum value Dmin when the system is new and increasing as wear increases. Dmin is less than Df. The pin (7), in the compressed state, has a height H equal to Dmin, and as the system becomes worn, H increases until reaching the value Df. The pin (7) comprises a recess (23) in its upper surface, and in the first portion (31) there is a projection (25), suitable for being housed in the recess (23).