公开(公告)号：US20210206926A1

公开(公告)日：2021-07-08

申请号：US17059804

申请日：2019-05-31

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Massimo BERTINO ,  Sylwia CZLONKA

IPC: C08J5/04 ,  C08L75/02 ,  C08L61/12 ,  C08J9/35 ,  C08J9/28 ,  C08J9/00 ,  C08G18/79 ,  C08G18/64 ,  C08G18/30 ,  C08G18/18 ,  C08G8/22 ,  B33Y70/00 ,  B29C48/00

Abstract: Polymeric aerogels, articles made from the polymeric aerogels and methods of making the polymeric aerogels are provided. The aerogels are made e.g. from crosslinkable monomers such as isocyanate monomers or phenolic monomers and a filler comprising crosslinkable hydroxyl groups. The filler may be natural (e.g. wood flour) or synthetic. The aerogels and products made therefrom exhibit low thermal conductivity and are mechanically strong. Due to their physical properties, these materials are used as e.g. building envelope components, such as walls, roofs and frames, to improve the thermal performance thereof, and may be used in a variety of other applications such as sound and insulation barriers in mechanical equipment, cryogenic containers, etc.

公开(公告)号：US20210187071A1

公开(公告)日：2021-06-24

申请号：US16754799

申请日：2018-10-26

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Anjan K. PRADHAN ,  Swadesh K. DAS ,  Luni EMDAD

IPC: A61K38/20 ,  A61K31/122 ,  A61K31/5377 ,  A61P35/04

Abstract: In various aspects, the present disclosure provides methods of preventing metastasis to bone in a subject with cancer, as well as compositions and kits for use in the same. In various aspects, the present disclosure provides methods of treating bone metastasis in a subject with cancer, as well as compositions and kits for use in the same. In embodiments, compositions comprise an MDA-7/IL-24 protein.

公开(公告)号：US20210169898A1

公开(公告)日：2021-06-10

申请号：US17094432

申请日：2020-11-10

Applicant: Virginia Commonwealth University ,  Durect Corporation

Inventor： Shunlin Ren ,  Leyuan Xu ,  Yanxia Ning ,  Jin Koung Kim ,  WeiQi Lin ,  Mee Jean Kim ,  Andrew R. Miksztal ,  Hongwei Wu ,  Min L. Lee ,  Wilma Tamraz

IPC: A61K31/565 ,  A61Q19/00 ,  A61K9/19 ,  A61P31/04 ,  A61K47/10 ,  A61K31/575 ,  A61K8/63 ,  A61P17/06 ,  A61K31/724 ,  A61K9/00 ,  A61P3/06 ,  A61K47/40 ,  A61K8/73 ,  A61P1/16 ,  C07J31/00

Abstract: Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.

公开(公告)号：US11014933B2

公开(公告)日：2021-05-25

申请号：US16726420

申请日：2019-12-24

Applicant: Virginia Commonwealth University

Inventor： Yan Zhang

IPC: C07D489/08

Abstract: Non-peptide MOR opioid receptor modulators are provided. The compounds exhibit predominantly central activity and are used to treat e.g. substance use disorders, and pain.

公开(公告)号：US20210147502A1

公开(公告)日：2021-05-20

申请号：US17082523

申请日：2020-10-28

Applicant: Virginia Commonwealth University

Inventor： Paul B. Fisher ,  Praveen Bhoopathi ,  Swadesh K. Das ,  Luni Emdad ,  Devanand Sarkar ,  Upneet Sokhi

IPC: C07K14/54

Abstract: Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.

公开(公告)号：US10980984B2

公开(公告)日：2021-04-20

申请号：US15955738

申请日：2018-04-18

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Hilton Bennett ,  William Paul Murphy ,  Bennett Ward ,  Nathan Minh Le ,  Ramya Nandigam ,  Sara Um

IPC: A61B5/00 ,  A61M25/09 ,  A61M25/01

Abstract: A guidewire retention clip is provided to prevent the accidental, complete insertion of a guidewire into a patient during various procedures. As provided herein, the guidewire retention clip may include a body having a portion configured to hold a guidewire; a sensor associated with the body configured to detect movement of the guidewire to and from the body; and an audio and/or visual indicator arranged on the body, wherein the audio and/or visual indicator is triggered when the sensor detects movement of the guidewire. Methods of using the guidewire retention clip are also provided.

公开(公告)号：US20210062084A1

公开(公告)日：2021-03-04

申请号：US16981452

申请日：2019-03-18

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Indika U. ARACHCHIGE ,  Umit OZGUR ,  Denis O. DEMCHENKO ,  Venkatesham TALLAPALLY ,  Tanner A. NAKAGAWARA

IPC: C09K11/66 ,  H01L51/42 ,  H01L51/44

Abstract: Colloidal synthesis of narrowly disperse, near IR emitting Group IV alloy quantum dots with wide range of Sn compositions via reduction of precursor halides is provided, allowing for less-toxic, earth abundant, and silicon-compatible Group IV alloy quantum dots for application in a broad range of electronic and photonic technologies.

公开(公告)号：US20210060522A1

公开(公告)日：2021-03-04

申请号：US16960217

申请日：2019-01-08

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： M. Samy EL-SHALL ,  Fathi Sami MOHAMED AWAD

IPC: B01J20/20 ,  B01J20/30 ,  C02F1/28

Abstract: Materials and methods for removing contaminants from liquids such as water are provided. The materials are graphene oxide-based materials that are chemically modified to comprise functional groups that adsorb a wide variety of pollutants such as heavy metals, nitrates, and phosphates.

公开(公告)号：US10888483B2

公开(公告)日：2021-01-12

申请号：US16069235

申请日：2017-01-12

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Mark Ostyn ,  Siyong Kim ,  Woon-Hong Yeo ,  Thomas Dwyer ,  Melvin Rosario ,  Ross Cruikshank ,  Daniel Martinez ,  Charles Cartin

IPC: A61G13/12 ,  A61G13/02 ,  A61B6/00

Abstract: A motion compensation system includes a plurality of RF transmitters, a plurality of direction of arrival sensors, and a positioning table which together are usable to compensate for intrafraction motion of a patient during a medical procedure. The positioning table may be a secondary table arranged next to or above a primary table such as a radiotherapy couch, allowing for repositioning of part of patient such as the head and neck relative to a remainder of the body. The motion compensation system employs a direction of arrival sensor that includes rotating antenna elements in a configuration that improves the ease and accuracy of signal processing and analysis to identify the position of an RF transmitter affixed to a patient. The repositioning table has six degrees of freedom and is safe for use in imaging and radiation intensive environments.

公开(公告)号：US10736951B2

公开(公告)日：2020-08-11

申请号：US16454797

申请日：2019-06-27

Applicant: Virginia Commonwealth University

Inventor： Jason A. Carlyon

IPC: A61K39/02 ,  A61K39/40 ,  C07K16/12 ,  G01N33/569 ,  A61K39/00

Abstract: Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. Asp14 and/or OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to Asp14 and/or OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection. Because of the conserved invasin domains in the surface proteins, a wide range of Anaplasmatacaea infections may be diagnosed, treated or prevented using compositions of the invention.