公开(公告)号：US20160108429A1

公开(公告)日：2016-04-21

申请号：US14895125

申请日：2014-06-04

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  THE JOHNS HOPKINS UNIVERSITY

Inventor： Paul B. FISHER ,  Swadesh K. Das ,  Mitchell E. MENEZES ,  Devanand Sarkar ,  Martin G. POMPER

IPC: C12N15/85 ,  A61K38/20 ,  C07K14/465 ,  C07K14/36 ,  C07K14/54 ,  A61N7/00 ,  A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  C12N15/86 ,  C12N7/00 ,  A61K49/00 ,  A61K41/00

CPC classification number: C12N15/85 ,  A61K38/164 ,  A61K38/1703 ,  A61K38/20 ,  A61K41/0028 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  A61K49/00 ,  A61N7/00 ,  A61N2007/0039 ,  B82Y5/00 ,  B82Y15/00 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/54 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/035 ,  C12N7/00 ,  C12N15/625 ,  C12N15/64 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2799/02 ,  C12N2799/022 ,  C12N2800/22 ,  C12N2810/855 ,  C12N2830/002 ,  C12N2830/008 ,  G01N33/50 ,  G01N33/574

Abstract: The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

Abstract translation: 目前公开的主题涉及涉及癌细胞核酸构建体的组合物和方法，其允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因的表达。

公开(公告)号：US20180243382A1

公开(公告)日：2018-08-30

申请号：US15758497

申请日：2016-09-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Xiang-Yang WANG ,  Paul B. FISHER ,  Xaiofei YU

IPC: A61K38/46 ,  A61K45/06 ,  C12N15/86

CPC classification number: A61K38/46 ,  A61K38/177 ,  A61K45/06 ,  C12N15/86 ,  C12N2710/10043 ,  C12Y306/04013

Abstract: Provided herein are methods and pharmaceutical compositions for treating cancer, such as prostate cancer. More specifically, MDA-5-encoding polynucleotides or MDA-5-encoding polypeptides, or functional derivatives thereof, are useful for inducing regression pre-established cancers and development of long-lasting antitumor immune memory.

公开(公告)号：US20210187071A1

公开(公告)日：2021-06-24

申请号：US16754799

申请日：2018-10-26

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Anjan K. PRADHAN ,  Swadesh K. DAS ,  Luni EMDAD

IPC: A61K38/20 ,  A61K31/122 ,  A61K31/5377 ,  A61P35/04

Abstract: In various aspects, the present disclosure provides methods of preventing metastasis to bone in a subject with cancer, as well as compositions and kits for use in the same. In various aspects, the present disclosure provides methods of treating bone metastasis in a subject with cancer, as well as compositions and kits for use in the same. In embodiments, compositions comprise an MDA-7/IL-24 protein.

公开(公告)号：US20160106866A1

公开(公告)日：2016-04-21

申请号：US14895556

申请日：2014-06-04

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Swadesh K. Das ,  Mitchell E. MENEZES ,  Devanand Sarkar ,  Martin G. Pomper

IPC: A61K48/00 ,  A61K51/00 ,  C12N15/87 ,  A61K49/00 ,  A61K41/00 ,  A61K38/20 ,  C12N7/00

CPC classification number: A61K48/0058 ,  A61K9/0019 ,  A61K38/20 ,  A61K41/0028 ,  A61K41/0033 ,  A61K49/0013 ,  A61K49/0045 ,  A61K49/0054 ,  A61K51/00 ,  A61K51/0491 ,  A61K51/12 ,  C07H21/04 ,  C12N7/00 ,  C12N15/86 ,  C12N15/87 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2710/16143 ,  C12N2710/16171 ,  C12N2830/008 ,  C12Q1/6897

Abstract: The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

Abstract translation: 目前公开的主题通常涉及其用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。 特别地，目前公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

公开(公告)号：US20190017054A1

公开(公告)日：2019-01-17

申请号：US16068230

申请日：2017-01-06

Applicant: Paul B. FISHER ,  Sarmishta TALUKDAR ,  Luni EMDAD ,  Swadesh K. DAS ,  VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Sarmistha TALUKDAR ,  Luni EMDAD ,  Swadesh K. DAS

IPC: C12N15/113 ,  G01N33/50 ,  A61P35/00 ,  G01N33/574

Abstract: This invention discloses a method of modulating the survival and stemness of cancer stem cells (CSCs) by modulating the expression of MDA-9/Syntenin (SDCBP), which regulates multiple stemness genes, and controls survival of CSCs by activating the pathways, including without limitation NOTCH1. In one embodiment, the stemness genes that can be regulated by modulating expression or activity of MDA-9/Syntenin (SDCBP) includes, but are not limited to, ALDH1A1, AXL, CD44, DDR1, ID1, ITGB1, c-myc, Nanog, NOTCH, Oct4/POU5F1, Sox2, and STAT3. The invention also discloses a method of decreasing/inhibiting CSCs's tumorigenicity and a method of increasing survival of a subject with cancer by suppression of mda-9. This invention provides a method of inhibiting the growth of a cancer, and a method of determining the metastatic or angiogenic potential of a cancer. This invention further provides a method of screening for a candidate compound that modulate the expression or activities of MDA-9/Syntenin (SDCBP).

公开(公告)号：US20180280435A1

公开(公告)日：2018-10-04

申请号：US15766212

申请日：2016-10-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Xiang-Yang WANG

IPC: A61K35/17 ,  C12N5/0783 ,  C07K14/54 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04

Abstract: Provided herein are methods and compositions useful for treating cancer, such as prostate cancer, through adoptive cell transfer of T cells derived from patients and genetically engineered to express MDA-7/IL-24 and/or other immune modulating agents. The methods described herein result in cancer cell death and reprogramming of the tumor immune compartment to restore antitumor immunity both at a primary tumor site and systemically.

公开(公告)号：US20180135130A1

公开(公告)日：2018-05-17

申请号：US15574283

申请日：2016-05-13

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Manny BACOLOD

IPC: C12Q1/6886

Abstract: Methods of prognosing the outcome of cancer and/or cancer treatment are provided. The methods involve quantitating the level of methylation at a site that regulates expression of the mda-9/Syntenin gene, site cg17197774. High levels of methylation indicate a good prognosis whereas low levels of methylation indicate a poor prognosis and determination of these levels permits risk stratification of patients with cancer.

公开(公告)号：US20230066830A1

公开(公告)日：2023-03-02

申请号：US17787483

申请日：2020-12-18

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Paul B. FISHER ,  Sarmistha TALUKDAR ,  Swadesh K. DAS ,  Anjan PRADHAN ,  Luni EMDAD

IPC: A61K31/519 ,  C12N15/113 ,  A61K31/337 ,  A61K31/439 ,  A61K31/165 ,  A61K31/18 ,  A61K31/4353 ,  A61K38/15 ,  A61K31/336 ,  A61K31/167 ,  A61K31/4406

Abstract: Provided herein are pharmaceutical compositions and methods useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

公开(公告)号：US20210214365A1

公开(公告)日：2021-07-15

申请号：US17148813

申请日：2021-01-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Inventor： Paul B. FISHER ,  Maurizio PELLECCHIA ,  Swadesh K. DAS ,  Timothy P. KEGELMAN ,  Bainan WU ,  Surya K. DE ,  Jun WEI ,  Mitchell E. MENEZES ,  Luni EMDAD

IPC: C07D487/04 ,  A61P35/04 ,  A61K31/519 ,  A61K45/06 ,  C07D495/14

Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

公开(公告)号：US20190263824A1

公开(公告)日：2019-08-29

申请号：US16349467

申请日：2017-11-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Inventor： Paul B. FISHER ,  Maurizio PELLECCHIA ,  Swadesh K. DAS ,  Timothy P. KEGELMAN ,  Bainan WU ,  Surya K. DE ,  Jun WEI ,  Mitchell E. MENEZES ,  Luni EMDAD

IPC: C07D487/04 ,  A61K45/06 ,  A61K31/519 ,  A61P35/04

Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.