公开(公告)号：US20110260074A1

公开(公告)日：2011-10-27

申请号：US12864002

申请日：2010-01-28

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Yuichi Yamamoto ,  Takaaki Iwata

IPC分类号： G21K1/08

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1048 ,  A61N2005/1087

摘要： The objective of the present invention is to reduce the effect of the hysteresis of a scanning electromagnet so as to obtain a particle beam therapy system that realizes high-accuracy beam irradiation. There are included an irradiation management apparatus (32) that controls the scanning electromagnet (3), based on target irradiation position coordinates (Pi) of a charged particle beam (1b), and a position monitor (7) that measures measurement position coordinates (Ps) of the charged particle beam (1b). The irradiation management apparatus (32) has a command value creator (25) that outputs a control input (Io (Ir)) to the scanning electromagnet (3), based on the target irradiation position coordinates (Pi) and correction data (Ia) created on the basis of the measurement position coordinates (Ps), measured by the position monitor (7) in the preliminary irradiation in which the excitation pattern of the scanning electromagnet is the same as that of the main irradiation plan, and the target irradiation position coordinates (Pi).

摘要翻译： 本发明的目的是减少扫描电磁体的滞后效果，以获得实现高精度光束照射的粒子束治疗系统。 包括基于带电粒子束（1b）的目标照射位置坐标（Pi）来控制扫描电磁体（3）的照射管理装置（32）和测量位置坐标（ Ps）的带电粒子束（1b）。 照射管理装置（32）具有基于目标照射位置坐标（Pi）和校正数据（Ia）向扫描电磁体（3）输出控制输入（Io（Ir））的指令值生成器（25） 基于由扫描电磁体的激励图案与主照射平面的激励图案相同的预备照射中的位置监视器（7）测量的测量位置坐标（Ps）和目标照射位置 坐标（Pi）。

公开(公告)号：US20110218429A1

公开(公告)日：2011-09-08

申请号：US12738705

申请日：2009-04-24

申请人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

发明人： Hisashi Harada ,  Takaaki Iwata ,  Taizo Honda ,  Yuehu Pu ,  Yuichi Yamamoto ,  Toshihiro Otani ,  Hidenobu Sakamoto

IPC分类号： G03B42/02 ,  H01J3/26

CPC分类号： A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject ; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.

摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。

公开(公告)号：US20100301228A1

公开(公告)日：2010-12-02

申请号：US12724844

申请日：2010-03-16

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/093 ,  G21K1/10 ,  G21K5/04

摘要： There is provided a particle beam therapy system that can rapidly change beam energy without increasing the size of a deflection electromagnet even in the case where the number of required beam-energy changes is large.There is provided a plurality of beam energy changing units each provided with a beam energy attenuation unit; a beam is deflected in such a way as to sequentially passes through the plurality of beam energy changing units; while a beam passes through one of the beam energy changing unit, the beam energy attenuation amount of another beam energy changing unit is changed.

摘要翻译： 提供了一种粒子束治疗系统，即使在所需的束能量变化的数量大的情况下，也可以快速地改变束能量而不增加偏转电磁体的尺寸。 提供了多个光束能量改变单元，每个光束能量改变单元均设有光束能量衰减单元; 光束以这样的方式被偏转，以便顺序地穿过多个光束能量改变单元; 当光束通过光束能量改变单元中的一个时，另一光束能量改变单元的光束能量衰减量改变。

公开(公告)号：US20090003524A1

公开(公告)日：2009-01-01

申请号：US12023134

申请日：2008-01-31

申请人： Yuehu PU

发明人： Yuehu PU

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A stacked conformation radiotherapy system capable of homogenizing a radiation dose distribution, including an irradiation head and irradiation control means. The irradiation head projects a particle beam accelerated by an accelerator, toward an object to-be-irradiated, and it includes wobbler electromagnets for deflecting and scanning the particle beam. In carrying out stacked conformation radiotherapy by deflecting and scanning the particle beam, the irradiation control means subjects the wobbler electromagnets to magnetization controls so that the particle beam may depict a one-stroke revolving orbit which begins with a start point and returns to the start point, and it performs a control so that the irradiation period of the particle beam to be outputted from the irradiation head may become integral times a wobbler cycle which is required for the particle beam to make one revolution of the revolving orbit.

摘要翻译： 一种能够使放射剂量分布均匀化的堆叠构象放射治疗系统，包括照射头和照射控制装置。 照射头投影由加速器加速的粒子束朝向被照射物体，并且其包括用于偏转和扫描粒子束的摆动电磁体。 在通过偏转和扫描粒子束进行堆叠构象放射治疗时，照射控制装置使摇摆电磁体进行磁化控制，使得粒子束可以描绘以起始点开始的一冲程旋转轨道，并返回起始点 ，并且进行控制，使得从照射头输出的粒子束的照射周期可以与粒子束进行旋转轨道一圈所需的摆动周期成为一个整数倍。

公开(公告)号：US20150360053A1

公开(公告)日：2015-12-17

申请号：US14761850

申请日：2013-01-22

申请人： Yuehu PU ,  Masahiro IKEDA ,  Taizo HONDA

发明人： Yuehu PU ,  Masahiro IKEDA ,  Taizo HONDA

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087

摘要： A particle beam irradiation system comprising a scanning electromagnet for a particle beam to scan an irradiation objective, a scanning information storage section for storing scanning position information regarding a plurality of scanning positions in a case where a particle beam scans an irradiation objective and scanning order information which is order for scanning a plurality of scanning positions, and a scanning electromagnet control section for controlling a scanning electromagnet based on scanning position information and scanning order information which is stored in the scanning information storage section, wherein the scanning position information which is stored in the scanning information storage section includes a part whose scanning position information is same as the scanning position information of adjacent order.

摘要翻译： 一种粒子束照射系统，包括用于粒子束的扫描电磁体扫描照射物镜;扫描信息存储部分，用于在粒子束扫描照射物镜和扫描命令信息的情况下存储关于多个扫描位置的扫描位置信息 扫描位置信息存储在扫描信息存储部中，扫描位置信息存储在扫描信息存储部中，扫描位置信息存储在扫描信息存储部中， 扫描信息存储部分包括扫描位置信息与相邻次序的扫描位置信息相同的部分。

公开(公告)号：US09101763B2

公开(公告)日：2015-08-11

申请号：US14240650

申请日：2011-11-03

申请人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

发明人： Masahiro Ikeda ,  Hisashi Harada ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Taizo Honda ,  Yukiko Yamada ,  Yuehu Pu

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1081 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A particle beam irradiation apparatus according to the present invention is provided with a vacuum duct that forms a vacuum region through which the charged particle beam passes, a vacuum window through which the charged particle beam is launched from the vacuum region, a scanning electromagnet that scans the charged particle beam; a monitoring apparatus including a position monitor that detects the passing position of a charged particle beam and the beam size thereof, a low-scattering gas filling chamber including the monitoring apparatus, and an irradiation management apparatus that controls irradiation of the charged particle beam; the particle beam irradiation apparatus is characterized in that the low-scattering gas filling chamber is changeably disposed in such a manner that the beam-axis-direction positional relationship between the monitoring apparatus and the vacuum window is a desired one and in that the low-scattering gas filling chamber is filled with a low-scattering gas.

摘要翻译： 根据本发明的粒子束照射装置设置有真空管道，该真空管道形成带电粒子束通过的真空区域，从真空区域发射带电粒子束的真空窗口，扫描的扫描电磁体 带电粒子束; 监视装置，其包括检测带电粒子束的通过位置的位置监视器及其光束尺寸，包括监视装置的低散射气体填充室以及控制带电粒子束的照射的照射管理装置; 所述粒子束照射装置的特征在于，所述低散射气体充填室可变地设置成使得所述监视装置和所述真空窗口之间的射束轴向位置关系是期望的， 散射气体填充室填充有低散射气体。

公开(公告)号：US09079026B2

公开(公告)日：2015-07-14

申请号：US14386626

申请日：2012-03-21

申请人： Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

发明人： Yuehu Pu ,  Masahiro Ikeda ,  Taizo Honda

IPC分类号： A61N5/10

CPC分类号： A61N5/1071 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1043 ,  A61N2005/1087

摘要： A particle beam scanning irradiation method includes the steps of calculating a planned irradiating particle count of a particle beam for each of irradiation spots, on the basis of a relative amount of particle beam irradiation and a prescription particle-beam dose determined from a particle-beam therapy plan; simulating an irradiation process of the particle beam at each irradiation spot, on the basis of the planned irradiating particle count and a beam current waveform of the particle beam, and calculating a particle count of the particle beam irradiating the diseased portion during a scan shift of the particle beam; correcting the planned irradiating particle count for each irradiation spot by using the irradiating particle count during the scan shift; converting the corrected planned-irradiation particle count into a count value used in a dose monitor; and irradiating the irradiation spot with the particle beam, on the basis of the converted count value.

摘要翻译： 粒子束扫描照射方法包括以下步骤：基于粒子束照射的相对量和从粒子束确定的处方粒子束剂量来计算每个照射点的粒子束的计划照射粒子数 治疗方案; 基于所计划的照射粒子数和粒子束的束电流波形，模拟在各照射点处的粒子束的照射过程，计算在扫描位移期间照射患病部位的粒子束的粒子数 粒子束; 通过使用扫描偏移期间的照射粒子数来校正每个照射点的计划照射粒子数; 将校正的计划照射粒子数转换为剂量监视器中使用的计数值; 并且基于转换后的计数值，用粒子束照射照射点。

公开(公告)号：US20150080631A1

公开(公告)日：2015-03-19

申请号：US14390087

申请日：2012-05-14

申请人： Yuehu Pu ,  Masahiro Ikeda

发明人： Yuehu Pu ,  Masahiro Ikeda

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1044 ,  A61N2005/1087 ,  F04C2270/0421

摘要： A particle beam scanning irradiation system includes a computer establishing a scanning sequence for irradiation of a tumor portion in a patient; and a particle beam irradiation device irradiating the tumor portion in accordance with the established scanning sequence of the particle beam. The computer selects all conceivable combinations of pairs of irradiation spots among the plurality of irradiation spots arranged in the tumor portion, and determines whether each path for the particle beam to shift between two spots constituting the selected pair passes through the tumor portion; determines a penalty matrix expressing whether each path passes through the tumor portion on the basis of the determination result; evaluates a function for the shift paths on the basis of an optimizing algorithm, and establishes the scanning sequence of the particle beam by an optimized solution of the function.

摘要翻译： 粒子束扫描照射系统包括建立用于照射患者肿瘤部分的扫描序列的计算机; 以及根据建立的粒子束扫描顺序照射肿瘤部分的粒子束照射装置。 计算机选择布置在肿瘤部分中的多个照射点之间的所有可能的照射点对的组合，并且确定用于粒子束在构成所选择的对的两个点之间移动的每个路径是否通过肿瘤部分; 根据确定结果确定表示每个路径是否通过肿瘤部分的惩罚矩阵; 基于优化算法对移位路径的功能进行评估，并通过优化的功能解决方案建立粒子束的扫描序列。

公开(公告)号：US08586948B2

公开(公告)日：2013-11-19

申请号：US13696736

申请日：2011-06-22

申请人： Yuehu Pu ,  Hisashi Harada ,  Taizo Honda

发明人： Yuehu Pu ,  Hisashi Harada ,  Taizo Honda

IPC分类号： G21K5/04

CPC分类号： G21K1/046 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1048 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10 ,  G21K5/00

摘要： A particle beam irradiation apparatus comprises a particle beam shielding member which shields a part of a particle beam which is scanned, a prompt signal detector which detects a prompt signal which is generated when the particle beam which is scanned collides with the particle beam shielding member and a signal comparison device which predicts and obtains a generation pattern of a prompt signal which is generated with a predetermined scanning pattern and stores as a signal time pattern for comparison, wherein the signal comparison device detects an abnormality of scanning of a particle beam or the particle beam shielding member by comparing a detected signal time pattern which is a time pattern of a signal which is detected by the prompt signal detector to a signal time pattern for comparison which is stored.

摘要翻译： 粒子束照射装置包括：屏蔽被扫描的粒子束的一部分的粒子束屏蔽构件;检测当被扫描的粒子束与粒子束屏蔽构件相撞时产生的提示信号的迅速信号检测器;以及 信号比较装置，其预测并获得以预定扫描图案生成的提示信号的生成模式，并存储为用于比较的信号时间图案，其中信号比较装置检测粒子束或粒子的扫描异常 通过将作为由快速信号检测器检测的信号的时间图案的检测信号时间图案与存储的用于比较的信号时间模式进行比较来检测光束屏蔽部件。

公开(公告)号：US08586942B2

公开(公告)日：2013-11-19

申请号：US13639998

申请日：2012-01-20

申请人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Yukiko Yamada

发明人： Taizo Honda ,  Hisashi Harada ,  Yuehu Pu ,  Masahiro Ikeda ,  Kazushi Hanakawa ,  Toshihiro Otani ,  Tadashi Katayose ,  Yukiko Yamada

IPC分类号： H01J3/10

CPC分类号： A61N5/1048 ,  A61N5/1043 ,  A61N5/1071 ,  A61N2005/1074 ,  A61N2005/1087 ,  G01T1/29 ,  G21K5/00 ,  G21K5/02

摘要： A charged particle beam position monitor is provided with a plurality of position monitors and a beam data processing device that performs calculation processing of the state of a charged particle beam, based on a plurality of signals outputted from the position monitors. The beam data processing device includes a plurality of channel data conversion units that perform AD conversion processing of the plurality of signals outputted from the position monitors; a position size processing unit, for each of the position monitors, that calculates the beam position of the beam, based on voltage information obtained through the AD conversion processing; and an integrated control unit that controls the plurality of channel data conversion units in such a way that while the beam is irradiated onto an irradiation subject, AD conversion processing of the signals is performed at different timings for the respective position monitors.

摘要翻译： 带电粒子束位置监视器具有多个位置监视器和根据从位置监视器输出的多个信号执行带电粒子束的状态的计算处理的波束数据处理装置。 所述波束数据处理装置包括对从所述位置监视器输出的所述多个信号进行AD转换处理的多个信道数据变换部; 基于通过AD转换处理获得的电压信息，对位置监视器中的每一个计算光束位置的位置尺寸处理单元; 以及集成控制单元，其以这样的方式控制多个通道数据转换单元，即当将光束照射到照射对象时，对于各个位置监视器，在不同的定时执行信号的AD转换处理。