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公开(公告)号：US20240159782A1
公开(公告)日：2024-05-16
申请号：US18418565
申请日：2024-01-22
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Ming Xia , Yushan Tan , Jun Chen , Erhua Cao , Genqian Li , Robert F. Zuk
IPC: G01N35/00 , B01L3/00 , G01N33/543
CPC classification number: G01N35/00 , B01L3/527 , G01N33/54353 , G01N33/54366 , B01L3/502 , B01L2200/16 , B01L2300/042 , G01N35/026
Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.
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公开(公告)号：US11879901B2
公开(公告)日：2024-01-23
申请号：US18166146
申请日：2023-02-08
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Ming Xia , Yushan Tan , Jun Chen , Erhua Cao , Genqian Li , Robert F. Zuk
CPC classification number: G01N35/00 , B01L3/527 , G01N33/54353 , G01N33/54366 , B01L3/502 , B01L2200/16 , B01L2300/042 , B01L2300/045 , G01N35/026 , G01N2035/0436
Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.
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公开(公告)号：US11604140B2
公开(公告)日：2023-03-14
申请号：US16380616
申请日：2019-04-10
Applicant: Access Medical Systems, Ltd.
Inventor： Hong Tan
Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly includes a light source to emit light signals; a light detector to detect light signals; a coupler to optically couple the light source and the light detector to a waveguide tip; a monolithic substrate having a coupling side and a sensing side; and a lens between the waveguide tip and the monolithic substrate. The lens relays optical signals between the waveguide tip and the monolithic substrate.
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公开(公告)号：US20210172970A1
公开(公告)日：2021-06-10
申请号：US17181868
申请日：2021-02-22
Applicant: Access Medical Systems, LTD.
Inventor： Hong Tan , Yongli Ren , Ming Xia , Genqian Li
IPC: G01N35/00 , B01L3/00 , B01L9/00 , G01N33/53 , G01N33/536
Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.
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Patent Agency Ranking
公开(公告)号：US09719936B2
公开(公告)日：2017-08-01
申请号：US14604584
申请日：2015-01-23
Applicant: ACCESS MEDICAL SYSTEMS, LTD.
Inventor： Hong Tan , Yushan Tan , Erhua Cao , Ming Xia , Robert F. Zuk
CPC classification number: G01N21/7703 , G01J3/45 , G01N21/45 , G01N21/648 , G01N21/8507 , G01N2021/7779 , G01N2201/062 , G01N2201/08 , G02B6/262 , G02B6/30
Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.
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公开(公告)号：US20150276724A1
公开(公告)日：2015-10-01
申请号：US14165381
申请日：2014-01-27
Applicant: Access Medical Systems, LTD.
Inventor： Robert F. ZUK , Hong Tan
IPC: G01N33/53
CPC classification number: G01N33/54393 , G01N21/76 , G01N27/3277 , G01N33/5306 , G01N33/533 , G01N33/5438 , G01N33/553 , G01N2021/757
Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise.
Abstract translation: 本发明涉及一种用于以高灵敏度检测液体样品中的分析物的发光免疫测定方法。 本发明提供了以下独特的组合：（i）使用具有小的感测表面积的探针来结合分析物分子，（ii）使用与多个结合分子共轭的高分子量支化聚合物和多个发光标记，以及（iii） 将具有免疫复合物的探针形成回试剂容器和扩增容器1-10次，并重复与试剂和扩增聚合物的反应，以提高检测水平的灵敏度。 对于每个循环，发光信号在噪声上显着增加。
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公开(公告)号：US20150204795A1
公开(公告)日：2015-07-23
申请号：US14604584
申请日：2015-01-23
Applicant: ACCESS MEDICAL SYSTEMS, LTD.
Inventor： Hong Tan , Yushan Tan , Erhua Cao , Ming Xia , Robert F. Zuk
CPC classification number: G01N21/7703 , G01J3/45 , G01N21/45 , G01N21/648 , G01N21/8507 , G01N2021/7779 , G01N2201/062 , G01N2201/08 , G02B6/262 , G02B6/30
Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.
Abstract translation: 本发明涉及一种用于基于薄膜光谱干涉检测样品中的分析物的组件。 组件包括波导，光耦合到波导的单片基板，以及直接结合到整体式基板的感测侧的薄膜层。 单片基板的折射率高于薄膜层的透明材料的折射率。 当样品中的分析物分子结合到涂覆在薄膜层上的分析物结合分子时，从第一反射表面和第二反射表面反射到波导中的光之间的光谱干涉变化。
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公开(公告)号：US20140093432A1
公开(公告)日：2014-04-03
申请号：US14095120
申请日：2013-12-03
Applicant: ACCESS MEDICAL SYSTEMS, LTD.
Inventor： Hong Tan , Yushan Tan , Erhua Cao , Min Xia , Robert F. Zuk
IPC: G01N21/45
CPC classification number: G01N21/7703 , G01J3/45 , G01N21/45 , G01N21/648 , G01N21/8507 , G01N2021/7779 , G01N2201/062 , G01N2201/08 , G02B6/262 , G02B6/30
Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.
Abstract translation: 本发明涉及一种用于基于薄膜光谱干涉检测样品中的分析物的组件。 组件包括波导，光耦合到波导的单片基板，以及直接结合到整体式基板的感测侧的薄膜层。 单片基板的折射率高于薄膜层的透明材料的折射率。 当样品中的分析物分子结合到涂覆在薄膜层上的分析物结合分子时，从第一反射表面和第二反射表面反射到波导中的光之间的光谱干涉变化。
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公开(公告)号：US08492139B2
公开(公告)日：2013-07-23
申请号：US13659576
申请日：2012-10-24
Applicant: Access Medical Systems, Ltd.
Inventor： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
IPC: C12M1/34 , G01N33/544
CPC classification number: G01N33/54366 , C08B37/006 , G01N21/6428 , G01N21/645 , G01N33/54373 , G01N2021/6439 , G01N2201/06113
Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.
Abstract translation: 本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。 该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。 本发明还涉及使用具有小表面积（@ 5mm）和具有多个结合分子和多个荧光标记的高分子量聚合物（> = 1 MD）的探针尖端来检测液体样品中的分析物的方法。 通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。 本发明进一步涉及包含具有多个结合分子和多个荧光标记的交联FICOLL®分子的荧光标记组合物。
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