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公开(公告)号：USD563853S1
公开(公告)日：2008-03-11
申请号：US29278169
申请日：2007-03-21
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32.发明授权
公开(公告)号：US5717688A
公开(公告)日：1998-02-10
申请号：US440436
申请日：1995-05-12
IPC分类号： H04B1/713 , H04B1/7143 , H04B1/7156 , H04L12/28 , H04Q7/20
CPC分类号： H04B1/7143 , H04B1/713 , H04B1/7156 , H04W36/08 , H04W76/02 , H04B2001/71563 , H04W24/00 , H04W28/26 , H04W36/00 , H04W48/08 , H04W48/16 , H04W48/20 , H04W74/004 , H04W74/006 , H04W74/0808 , H04W8/005 , H04W84/12 , H04W88/08
摘要： A wireless network transmits information to mobile units which indicate communication ranges of particular access point units. Each mobile unit scans traffic on the network communications channel (typically frequency hopping radio transmissions using spread spectrum). As a mobile unit leaves one area and enters another area of the network, access point units in the new area transmit information, which the mobile unit receives. The transmission includes information indicating which access point units are within radio range of the mobile unit as well as multiple values indicating a communication range for a particular access point unit to the mobile unit. The mobile unit uses this information to establish communication with desired access point units.
摘要翻译： 无线网络向指示特定接入点单元的通信范围的移动单元发送信息。 每个移动单元扫描网络通信信道上的通信量（通常是使用扩频的跳频无线电传输）。 当移动单元离开一个区域并进入网络的另一个区域时，新区域中的接入点单元发送移动单元接收的信息。 该传输包括指示哪个接入点单元在移动单元的无线电范围内的信息以及指示针对移动单元的特定接入点单元的通信范围的多个值。 移动单元使用该信息来建立与期望的接入点单元的通信。
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公开(公告)号：US4722071A
公开(公告)日：1988-01-26
申请号：US725084
申请日：1985-04-19
申请人： Dirk I. Gates , David B. Rosen , Gary A. Jones
发明人： Dirk I. Gates , David B. Rosen , Gary A. Jones
CPC分类号： G06F8/447 , G05B19/056
摘要： An intelligent compiler particularly useful for evaluating Boolean expressions such as those associated with ladder structures. True/false paths are defined through the expressions. In a first pass for the code generation, the start code for examining each element is set out. In a second pass the relative offsets for branching from one element to the next element along both the true and false paths are filled in. In practice, execution time for evaluating ladder structures is reduced by an order of magnitude over prior techniques which use source code and an interpreter.
摘要翻译： 一个智能编译器特别适用于评估布尔表达式，例如与梯形结构相关联的表达式。 True / false路径是通过表达式定义的。 在代码生成的第一遍中，设置用于检查每个元素的起始代码。 在第二遍中，填充了从一个元素到另一个元素沿着真实和虚假路径的分支的相对偏移量。实际上，用于评估梯形图结构的执行时间比使用源代码的先前技术减少了一个数量级 和口译员。
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公开(公告)号：US20130035253A1
公开(公告)日：2013-02-07
申请号：US13566991
申请日：2012-08-03
申请人： David B. Rosen , Santosh K. Putta , Brent Louie , Norman Purvis
发明人： David B. Rosen , Santosh K. Putta , Brent Louie , Norman Purvis
IPC分类号： G01N33/574 , G01N27/62 , C40B30/04 , G01N21/64
CPC分类号： G01N33/57426 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations.
摘要翻译： 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。
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公开(公告)号：US08273544B2
公开(公告)日：2012-09-25
申请号：US13083156
申请日：2011-04-08
申请人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
发明人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC分类号： G01N33/53 , G01N33/567 , G01N33/00
CPC分类号： G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
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公开(公告)号：US20120215481A1
公开(公告)日：2012-08-23
申请号：US13399489
申请日：2012-02-17
申请人： Todd M. Covey , Darwin A. Farrow , Barton J. Friedland , Helen Francis-Lang , Malcolm Francis-Lang , Justin W. Mccarthy , Norman B. Purvis, JR. , Santosh K. Putta , David B. Rosen , David M. Soper , David C. Spellmeyer
发明人： Todd M. Covey , Darwin A. Farrow , Barton J. Friedland , Helen Francis-Lang , Malcolm Francis-Lang , Justin W. Mccarthy , Norman B. Purvis, JR. , Santosh K. Putta , David B. Rosen , David M. Soper , David C. Spellmeyer
IPC分类号： G06F19/00
CPC分类号： G01N35/00663 , G01N15/1404 , G01N35/00712
摘要： In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.
摘要翻译： 在一个实施例中，一种方法包括从存储在物理库存中的样本池发送样本的可用性的指示符。 基于满足与样本池相关联的条件的样本的属性，将样本包含在样本池中。 收到样本已经从样本池中选择用于在包含在测试点阵列中的第一测试位点进行分析的指示符。 基于与第一测试站点相关联的实验参数值从规则数据库检索规则。 基于满足规则内的条件，修改与第一测试站点相关联的实验参数值中的至少一个或与第二测试站点相关联的实验参数值。
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公开(公告)号：US08227202B2
公开(公告)日：2012-07-24
申请号：US12460029
申请日：2009-07-10
申请人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , Garry Nolan , Aileen Cohen , Erik Evensen
发明人： Wendy J. Fantl , David B. Rosen , Alessandra Cesano , Santosh K. Putta , Garry Nolan , Aileen Cohen , Erik Evensen
IPC分类号： G01N33/53 , G01N33/567 , G01N33/00
CPC分类号： G01N33/57426 , G01N33/5041 , G01N33/5044 , G01N33/5055 , G01N33/5073 , G01N33/6893 , G01N2333/70589 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译： 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于激活状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及鉴定在细胞群体内表现出相关的激活变化。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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公开(公告)号：US20110269154A1
公开(公告)日：2011-11-03
申请号：US13083156
申请日：2011-04-08
申请人： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
发明人： Wendy J. FANTL , David B. Rosen , Alessandra Cesano , Santosh K. Putta , James R. Hackett , Michael Walker , Jing Shi
IPC分类号： G01N33/567 , G01N33/574
CPC分类号： G01N33/57426 , A61K31/4709 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K31/7076 , G01N33/50 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5073 , G01N33/5094 , G01N33/53 , G01N33/574 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/22 , G01N2800/52
摘要： The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
摘要翻译： 本发明提供了用于确定单细胞中多种蛋白质的活化状态的方法。 这种方法允许基于活化状态，表达标志物和其他标准快速检测复杂细胞群体中的异质性，以及在细胞群体内表现出相关的激活变化的细胞亚群的鉴定。 此外，这种方法允许细胞活动或性质的相关性。 此外，使用细胞激活的调节剂允许表征途径和细胞群体。 可以使用本发明分析的几种示例性疾病包括AML，MDS和MPN。
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公开(公告)号：US5729680A
公开(公告)日：1998-03-17
申请号：US439337
申请日：1995-05-11
IPC分类号： H04B1/713 , H04B1/7143 , H04B1/7156 , H04L12/28 , G06F15/16 , H04L9/00
CPC分类号： H04B1/7143 , H04B1/713 , H04B1/7156 , H04W36/08 , H04W76/02 , H04B2001/71563 , H04W24/00 , H04W28/26 , H04W36/00 , H04W48/08 , H04W48/16 , H04W48/20 , H04W74/004 , H04W74/006 , H04W74/0808 , H04W8/005 , H04W84/12 , H04W88/08
摘要： A wireless network is initialized by communications between mobile units forming an ad hoc network or by communications between a mobile unit and an access point unit. Mobile units transmit announcements in order to establish a communication link. To ensure the announcements are received, the mobile units scan different frequencies at various times using various hop sequences. Once communication is established, one mobile unit adopts the hop frequency of the other mobile unit according to a comparison between the hop frequencies of the two units. Multiple mobile units initialize to form ad hoc networks in similar manner.
摘要翻译： 通过形成自组织网络的移动单元之间的通信或通过移动单元和接入点单元之间的通信来进行无线网络的初始化。 移动单元发送通知以建立通信链路。 为了确保接收到通知，移动单元使用各种跳跃序列在不同时间扫描不同的频率。 一旦建立通信，一个移动单元根据两个单元的跳频之间的比较来采用另一个移动单元的跳频。 多个移动单元以类似的方式初始化以形成ad hoc网络。
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公开(公告)号：US5232364A
公开(公告)日：1993-08-03
申请号：US937144
申请日：1992-08-31
申请人： David B. Rosen
发明人： David B. Rosen
CPC分类号： A61C7/00 , A61C8/00 , A61C8/0096
摘要： A support plate for an orthodontic anchorage fitting designed to be removably attached to a dental crown analog. The plate has curved slots at each end for passage of screws used to attach it to a sidewall of the analog, so that the plate can be adjusted on the sidewall around an axis that is between the slots. Pivot means can be provided in the sidewall and the plate for locating the plate pivotally on the sidewall. The plate is made of a material, such as stainless steel, to which an orthodontic anchorage fitting may be attached by welding.
摘要翻译： 用于正畸固定配件的支撑板，其设计成可移除地附接到牙冠模拟物。 板在每个端部具有弯曲的狭槽，用于通过用于将其附接到模拟的侧壁的螺钉，使得板可以围绕围绕在槽之间的轴线调节在侧壁上。 枢转装置可以设置在侧壁和板中，用于将板枢转地定位在侧壁上。 该板由诸如不锈钢的材料制成，通过焊接可以将正畸锚固配件附接到该材料上。
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