公开(公告)号：US07079132B2

公开(公告)日：2006-07-18

申请号：US10222182

申请日：2002-08-16

申请人： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

发明人： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

IPC分类号： G06T15/00

CPC分类号： A61B8/467 ,  A61B8/00 ,  A61B8/462 ,  A61B8/466 ,  A61B8/483 ,  A61B8/5238 ,  G01S7/52034 ,  G01S7/52036 ,  G01S7/52068 ,  G01S7/52084 ,  G01S15/8993

摘要： A method for local 3-dimensional (3D) reconstruction from 2-dimensional (2D) ultrasound images includes deriving a 2D image of an object; defining a target region within said 2D image; defining a volume scan period; during the volume scan period, deriving further 2D images of the target region and storing respective pose information for the further 2D images; and reconstructing a 3D image representation for the target region by utilizing the 2D images and the respective pose information.

公开(公告)号：US06236459B1

公开(公告)日：2001-05-22

申请号：US09186428

申请日：1998-11-05

申请人： Shahriar Negahdaripour ,  Ali Khamene

发明人： Shahriar Negahdaripour ,  Ali Khamene

IPC分类号： G01B902

CPC分类号： A61B3/101 ,  G01B11/0675

摘要： An interferometric thin film measuring device has a source of illumination light, a detector disposed in a return path of light reflected from a specimen of illumination light, a plurality of wavelength filters that filter light into image channels, a weight vector calculating device that receives detected signals, a look-up table storage unit that stores calibration weight vectors, a weight vector comparing unit that compares calibration weight vectors from the look-up table storage unit to subject weight vectors, and a data output/storage unit to output the measured thin film values.

摘要翻译： 一种干涉式薄膜测量装置具有照明光源，设置在从照明光的样本反射的光的返回路径中的检测器，将光过滤成图像通道的多个波长滤波器，接收检测到的重量向量计算装置 信号，存储校准权重向量的查找表存储单元，将来自查找表存储单元的校准权重向量与对象权重向量进行比较的权重向量比较单元，以及数据输出/存储单元， 电影价值。

公开(公告)号：US08218909B2

公开(公告)日：2012-07-10

申请号：US12198190

申请日：2008-08-26

申请人： Ali Khamene ,  Fabrice Michel

发明人： Ali Khamene ,  Fabrice Michel

IPC分类号： G06K9/32

CPC分类号： G06K9/6206

摘要： A method for deformable registration of 2 digital images includes providing a pair of digital images, including a fixed image and a moving image, extracting a set of edge images from each image of the pair of images, each edge set being extracted at a different resolution, selecting a pair of edge images with a lowest resolution, determining a mapping from edge points of the fixed image to edge points of moving image using a geodesic thin plate spline interpolation, applying the mapping to a next higher resolution edge point image of the moving image, selecting a pair of edge images at a next higher resolution, where a moving edge image is the moving edge image to which the mapping has been applied, repeating the steps at a next higher resolution for all edge images in the set of edge images, and applying the mapping to an entire moving image.

摘要翻译： 一种用于2个数字图像的可变形登记的方法包括提供一对数字图像，包括固定图像和运动图像，从该对图像的每个图像中提取一组边缘图像，每个边缘集以不同的分辨率提取 选择具有最低分辨率的一对边缘图像，使用测地板薄板样条插值确定从固定图像的边缘点到运动图像的边缘点的映射，将该映射应用于移动的下一较高分辨率边缘点图像 图像，以下一较高分辨率选择一对边缘图像，其中移动边缘图像是已应用映射的移动边缘图像，以下一组边缘图像中的所有边缘图像重复下一个更高分辨率的步骤 ，并将映射应用于整个运动图像。

公开(公告)号：US07787683B2

公开(公告)日：2010-08-31

申请号：US11303564

申请日：2005-12-16

申请人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

发明人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

IPC分类号： G06K9/00

CPC分类号： G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

摘要： A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

摘要翻译： 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US20090285357A1

公开(公告)日：2009-11-19

申请号：US12406233

申请日：2009-03-18

申请人： Ali Khamene ,  Stefan Käpplinger ,  Gabriel Haras ,  Eike Rietzel

发明人： Ali Khamene ,  Stefan Käpplinger ,  Gabriel Haras ,  Eike Rietzel

IPC分类号： H05G1/60 ,  A61B6/04 ,  G01D18/00

CPC分类号： A61B6/08 ,  A61B5/0064 ,  A61B6/5217 ,  A61B6/5247 ,  A61B6/541 ,  A61B6/583 ,  A61N5/1037 ,  A61N5/1049 ,  A61N2005/1059

摘要： A patient positioning system for positioning a patient relative to radiographic equipment. The system includes: a 3D optical imaging system for optically scanning the patient, such 3D optical imaging system having a focal plane and providing, for each position on the object, data representative of the intensity of reflected energy received by the system from such position and data representative of distance from such position on the object to the focal plane; a table apparatus for supporting the patient and for moving the table relative to the radiographic equipment in response to positioning signals; and a processor responsive to data from the radiographic equipment and the data from the a 3D optical imaging system for producing the positioning signals. The system enables a method for displaying temporal changes in a patient positioned with a bore of radiographic equipment.

摘要翻译： 一种用于相对于射线照相设备定位患者的患者定位系统。 该系统包括：用于光学扫描患者的3D光学成像系统，具有焦平面的3D光学成像系统，并且为对象上的每个位置提供表示系统从该位置接收的反射能量的强度的数据，以及 表示从物体上的这种位置到焦平面的距离的数据; 用于响应于定位信号而支撑患者并相对于射线照相设备移动台的桌子装置; 以及响应于来自放射线照相设备的数据和来自3D光学成像系统的数据的处理器，用于产生定位信号。 该系统实现了一种用于在放射照相设备的孔定位的患者中显示时间变化的方法。

公开(公告)号：US20090067755A1

公开(公告)日：2009-03-12

申请号：US12198190

申请日：2008-08-26

申请人： Ali Khamene ,  Fabrice Michel

发明人： Ali Khamene ,  Fabrice Michel

IPC分类号： G06K9/32

CPC分类号： G06K9/6206

摘要： A method for deformable registration of 2 digital images includes providing a pair of digital images, including a fixed image and a moving image, extracting a set of edge images from each image of the pair of images, each edge set being extracted at a different resolution, selecting a pair of edge images with a lowest resolution, determining a mapping from edge points of the fixed image to edge points of moving image using a geodesic thin plate spline interpolation, applying the mapping to a next higher resolution edge point image of the moving image, selecting a pair of edge images at a next higher resolution, where a moving edge image is the moving edge image to which the mapping has been applied, repeating the steps at a next higher resolution for all edge images in the set of edge images, and applying the mapping to an entire moving image.

摘要翻译： 一种用于2个数字图像的可变形登记的方法包括提供一对数字图像，包括固定图像和运动图像，从该对图像的每个图像中提取一组边缘图像，每个边缘集以不同的分辨率提取 选择具有最低分辨率的一对边缘图像，使用测地板薄板样条插值确定从固定图像的边缘点到运动图像的边缘点的映射，将该映射应用于移动的下一较高分辨率边缘点图像 图像，以下一较高分辨率选择一对边缘图像，其中移动边缘图像是已应用映射的移动边缘图像，以下一组边缘图像中的所有边缘图像重复下一个更高分辨率的步骤 ，并将映射应用于整个运动图像。

公开(公告)号：US20090052757A1

公开(公告)日：2009-02-26

申请号：US12192278

申请日：2008-08-15

申请人： Ali Khamene ,  Oliver Fluck ,  Shmuel Aharon

发明人： Ali Khamene ,  Oliver Fluck ,  Shmuel Aharon

IPC分类号： G06K9/00

CPC分类号： G06K9/00208 ,  A61B6/032 ,  A61B6/5229 ,  A61B6/5235 ,  A61N5/103 ,  A61N5/1049 ,  A61N2005/1062 ,  G06T7/30 ,  G06T2207/10072 ,  G06T2207/10124 ,  G06T2207/30004

摘要： A method for deformable registration including determining a vector field from a two-dimensional matching of a volume of an object of interest and a two-dimensional image of the object of interest, providing a deformation profile, and finding a volume deformation that maps to a state of the two-dimensional image, wherein the deformation is parameterized by the vector field and control points of the deformation profile to find a control point configuration of the volume deformation.

摘要翻译： 一种用于可变形配准的方法，包括从感兴趣对象的体积和感兴趣对象的二维图像的二维匹配中确定矢量场，提供变形曲线，以及找到映射到 二维图像的状态，其中通过矢量场和变形曲线的控制点参数化变形，以找到体积变形的控制点配置。

公开(公告)号：US20080287787A1

公开(公告)日：2008-11-20

申请号：US11649391

申请日：2007-01-03

申请人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

发明人： Frank Sauer ,  Ali Khamene ,  Oliver Kutter ,  Sebastian Kassner

IPC分类号： A61B8/13

CPC分类号： A61B8/12 ,  A61B5/062 ,  A61B8/0833 ,  A61B8/4254 ,  A61B8/483 ,  A61B8/587 ,  B33Y80/00

摘要： Apparatus for calibrating an ultrasound transducer providing B-scans for two-dimensional (2D) images, includes: an ultrasound probe for providing B-scans; a position sensing device, the position sensing device being attached to the ultrasound probe and operating as part of a position sensing system in cooperation with a fixed sensing control unit, for labeling the B-scans with their respective relative positions and orientations (pose); a phantom marker for being imaged by the ultrasound probe for providing measurements which together with known physical properties of the phantom marker are used to derive calibration information for relating measurement data from the position sensing device to the poses of the B-scans to construct a 3D image; and the phantom marker comprising an encoded line object with distinctive calibration characteristics indicative of position along the line object, wherein the line object is disposed in a generally circumferential manner about a common axis with the probe.

摘要翻译： 用于校准提供二维（2D）图像的B扫描的超声换能器的装置包括：用于提供B扫描的超声探头; 位置感测装置，所述位置感测装置附接到所述超声波探头，并且作为与固定感测控制单元协作的位置感测系统的一部分进行操作，用于以它们各自的相对位置和取向（姿势）标记B扫描; 用于由超声波探头成像的用于提供测量的幻影标记，其与模拟标记的已知物理特性一起用于导出校准信息，用于将来自位置感测装置的测量数据与B扫描的姿态相关联以构建3D 图片; 并且所述假想标记包括具有指示沿着所述线对象的位置的独特校准特性的编码线对象，其中所述线对象以围绕所述探针的公共轴线大致圆周方式设置。

公开(公告)号：US20080031404A1

公开(公告)日：2008-02-07

申请号：US11831090

申请日：2007-07-31

申请人： Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

发明人： Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

IPC分类号： A61B6/00

CPC分类号： A61N5/1049 ,  A61B5/113 ,  A61B5/1135 ,  A61B6/032 ,  A61B6/541 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062

摘要： A method for four-dimensional (4D) image verification in respiratory gated radiation therapy, includes: acquiring 4D computed tomography (CT) images, each of the 4D CT images representing a breathing phase of a patient and tagged with a corresponding time point of a first surrogate signal; acquiring fluoroscopic images of the patient under free breathing, each of the fluoroscopic images tagged with a corresponding time point of a second surrogate signal; generating digitally reconstructed radiographs (DRRs) for each breathing phase represented by the 4D CT images; generating a similarity matrix to assess a degree of resemblance in a region of interest between the DRRs and the fluoroscopic images; computing a compounded similarity matrix by averaging values of the similarity matrix across different time points of the breathing phase during a breathing period of the patient; determining an optimal time point synchronization between the DRRs and the fluoroscopic images by using the compounded similarity matrix; and acquiring a third surrogate signal and turning a treatment beam on or off according to the optimal time point synchronization.

摘要翻译： 呼吸门控放射治疗中四维（4D）图像验证的方法包括：获取4D计算机断层摄影（CT）图像，每个4D CT图像代表患者的呼吸阶段，并用相应的时间点标记 第一替代信号; 在自由呼吸下获取患者的透视图像，每个透视图像标记有第二替代信号的相应时间点; 为由4D CT图像表示的每个呼吸阶段生成数字重建X射线照片（DRR）; 生成相似性矩阵以评估DRR和荧光透视图像之间的感兴趣区域中的相似程度; 通过在患者的呼吸期间在呼吸阶段的不同时间点平均相似性矩阵的值来计算复合相似性矩阵; 通过使用复合相似度矩阵确定DRR和荧光透视图像之间的最佳时间点同步; 并根据最佳时间点同步获取第三替代信号并打开或关闭治疗束。

公开(公告)号：US20070248251A1

公开(公告)日：2007-10-25

申请号：US11686533

申请日：2007-03-15

申请人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

发明人： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

IPC分类号： G06K9/00 ,  G06T11/00

CPC分类号： G06K9/00208 ,  G06K9/6212 ,  G06T7/33 ,  G06T7/35 ,  G06T2207/30101

摘要： A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.

摘要翻译： 在医疗过程中将三维数字化图像记录到二维数字化图像的方法包括提供一对正确注册的训练图像L =（1/2） >}和它们的联合强度分布p（i），其中i i和i i f分别是提供一对观察图像的参考和浮动图像，它们的联合强度分布 映射所观察到的对的边缘强度分布O = {o 以及训练对的边缘强度分布L = {1> 1，...，...），并且估计一组 通过最大化所观察到的对的联合强度分布的Jensen-Shannon发散（JSD）的加权和来加权对照图像的参数T，以使图像o 训练对的联合强度分布 以及观察到的图像之间的相似性度量。