公开(公告)号：US20080031404A1

公开(公告)日：2008-02-07

申请号：US11831090

申请日：2007-07-31

申请人： Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

发明人： Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

IPC分类号： A61B6/00

CPC分类号： A61N5/1049 ,  A61B5/113 ,  A61B5/1135 ,  A61B6/032 ,  A61B6/541 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062

摘要： A method for four-dimensional (4D) image verification in respiratory gated radiation therapy, includes: acquiring 4D computed tomography (CT) images, each of the 4D CT images representing a breathing phase of a patient and tagged with a corresponding time point of a first surrogate signal; acquiring fluoroscopic images of the patient under free breathing, each of the fluoroscopic images tagged with a corresponding time point of a second surrogate signal; generating digitally reconstructed radiographs (DRRs) for each breathing phase represented by the 4D CT images; generating a similarity matrix to assess a degree of resemblance in a region of interest between the DRRs and the fluoroscopic images; computing a compounded similarity matrix by averaging values of the similarity matrix across different time points of the breathing phase during a breathing period of the patient; determining an optimal time point synchronization between the DRRs and the fluoroscopic images by using the compounded similarity matrix; and acquiring a third surrogate signal and turning a treatment beam on or off according to the optimal time point synchronization.

摘要翻译： 呼吸门控放射治疗中四维（4D）图像验证的方法包括：获取4D计算机断层摄影（CT）图像，每个4D CT图像代表患者的呼吸阶段，并用相应的时间点标记 第一替代信号; 在自由呼吸下获取患者的透视图像，每个透视图像标记有第二替代信号的相应时间点; 为由4D CT图像表示的每个呼吸阶段生成数字重建X射线照片（DRR）; 生成相似性矩阵以评估DRR和荧光透视图像之间的感兴趣区域中的相似程度; 通过在患者的呼吸期间在呼吸阶段的不同时间点平均相似性矩阵的值来计算复合相似性矩阵; 通过使用复合相似度矩阵确定DRR和荧光透视图像之间的最佳时间点同步; 并根据最佳时间点同步获取第三替代信号并打开或关闭治疗束。

公开(公告)号：US07570738B2

公开(公告)日：2009-08-04

申请号：US11831090

申请日：2007-07-31

申请人： Ali Khamene ,  Charles Henri Florin ,  Juan Carlos Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

发明人： Ali Khamene ,  Charles Henri Florin ,  Juan Carlos Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

IPC分类号： A61N5/10 ,  A61B6/02 ,  A61B6/03

CPC分类号： A61N5/1049 ,  A61B5/113 ,  A61B5/1135 ,  A61B6/032 ,  A61B6/541 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062

摘要： A method for four-dimensional (4D) image verification in respiratory gated radiation therapy, includes: acquiring 4D computed tomography (CT) images, each of the 4D CT images representing a breathing phase of a patient and tagged with a corresponding time point of a first surrogate signal; acquiring fluoroscopic images of the patient under free breathing, each of the fluoroscopic images tagged with a corresponding time point of a second surrogate signal; generating digitally reconstructed radiographs (DRRs) for each breathing phase represented by the 4D CT images; generating a similarity matrix to assess a degree of resemblance in a region of interest between the DRRs and the fluoroscopic images; computing a compounded similarity matrix by averaging values of the similarity matrix across different time points of the breathing phase during a breathing period of the patient; determining an optimal time point synchronization between the DRRs and the fluoroscopic images by using the compounded similarity matrix; and acquiring a third surrogate signal and turning a treatment beam on or off according to the optimal time point synchronization.

摘要翻译： 呼吸门控放射治疗中四维（4D）图像验证的方法包括：获取4D计算机断层摄影（CT）图像，每个4D CT图像代表患者的呼吸阶段，并用相应的时间点标记 第一替代信号; 在自由呼吸下获取患者的透视图像，每个透视图像标记有第二替代信号的相应时间点; 为由4D CT图像表示的每个呼吸阶段生成数字重建X射线照片（DRR）; 生成相似性矩阵以评估DRR和荧光透视图像之间的感兴趣区域中的相似程度; 通过在患者的呼吸期间在呼吸阶段的不同时间点平均相似性矩阵的值来计算复合相似性矩阵; 通过使用复合相似度矩阵确定DRR和荧光透视图像之间的最佳时间点同步; 并根据最佳时间点同步获取第三替代信号并打开或关闭治疗束。

公开(公告)号：US20060188139A1

公开(公告)日：2006-08-24

申请号：US11303564

申请日：2005-12-16

申请人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James Williams

发明人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James Williams

IPC分类号： G06K9/00

CPC分类号： G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

摘要： A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

摘要翻译： 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US07787683B2

公开(公告)日：2010-08-31

申请号：US11303564

申请日：2005-12-16

申请人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

发明人： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James P. Williams

IPC分类号： G06K9/00

CPC分类号： G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

摘要： A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

摘要翻译： 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US20070014462A1

公开(公告)日：2007-01-18

申请号：US11452169

申请日：2006-06-13

申请人： Mikael Rousson ,  Ali Khamene ,  Mamadou Diallo

发明人： Mikael Rousson ,  Ali Khamene ,  Mamadou Diallo

IPC分类号： G06K9/00 ,  G06K9/34

CPC分类号： G06T7/149 ,  G06T7/11 ,  G06T7/143 ,  G06T2207/10081 ,  G06T2207/20101 ,  G06T2207/20161 ,  G06T2207/30004 ,  G06T2207/30081

摘要： A Bayesian formulation for coupled surface evolutions in level set methods and application to the segmentation of the prostate and the bladder in CT images are disclosed. A Bayesian framework imposing a shape constraint on the prostate is also disclosed, while coupling its shape extraction with that of the bladder. Constraining the segmentation process improves the extraction of both organs' shapes.

摘要翻译： 公开了一种用于水平集方法中耦合表面演化的贝叶斯公式，用于CT图像中前列腺和膀胱分割的应用。 还公开了对前列腺施加形状约束的贝叶斯框架，同时将其形状提取与膀胱的形状提取相结合。 限制分割过程改善了两个器官形状的提取。

公开(公告)号：US09681925B2

公开(公告)日：2017-06-20

申请号：US11107640

申请日：2005-04-15

申请人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

发明人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Sebastian Vogt

IPC分类号： A61B5/05 ,  A61B90/00 ,  A61B34/20 ,  A61B90/11 ,  A61B34/10

CPC分类号： A61B90/36 ,  A61B34/10 ,  A61B34/20 ,  A61B90/11 ,  A61B90/361 ,  A61B2034/107 ,  A61B2090/365

摘要： A system and method for instrument placement using an image based navigation system is disclosed. A target of interest is identified in a medical image of a patient. An image plane is displayed that goes through a center of the target. The image plane has a configurable orientation. The image plane is used to select a path for an instrument from a position on the patient's skin to the center of the target. A trajectory plane is viewed from a tip of the instrument to the center of the target. The trajectory plane reflects an orientation of the instrument. A particular trajectory plane is selected that is representative of a desired orientation of the instrument. An image of the particular trajectory plane is frozen. The instrument can then be inserted using a virtual guide and is navigated toward the target.

公开(公告)号：US08244332B2

公开(公告)日：2012-08-14

申请号：US11292338

申请日：2005-12-01

申请人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

发明人： Fred S. Azar ,  Ali Khamene ,  Frank Sauer ,  Bruce Tromberg ,  Albert Cerussi

IPC分类号： A61B6/00

CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B34/20 ,  A61B2034/105 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/373 ,  G01N21/359 ,  G01N21/474 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2021/4745 ,  G01N2201/0221 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/08

摘要： A diffuse optical spectroscopy system comprises a laser breast scanner, a handheld probe connected to the laser breast scanner for scanning a breast, and a tracking device coupled to the handheld probe, wherein the tracking device determines locations of the handheld probe relative to the breast. The tracking device comprises a magnetic tracking device, an optical tracking device or a laser tracking device.

摘要翻译： 扩散光谱系统包括激光乳房扫描器，连接到用于扫描乳房的激光乳房扫描器的手持式探头以及耦合到手持探针的跟踪装置，其中跟踪装置确定手持式探针相对于乳房的位置。 跟踪装置包括磁跟踪装置，光学跟踪装置或激光跟踪装置。

公开(公告)号：US07711405B2

公开(公告)日：2010-05-04

申请号：US10833742

申请日：2004-04-28

申请人： Ali Khamene ,  Frank Sauer

发明人： Ali Khamene ,  Frank Sauer

IPC分类号： A61B5/05

CPC分类号： G01R33/56 ,  G01R33/5608

摘要： A system and method for registering pre-operative magnetic resonance (MR) images with intra-operative MR images is disclosed. A pre-operative MR image of an object is received. A set of intra-operative MR images of the object is received. The pre-operative MR image is rigidly registered with the initial intra-operative MR image. The subsequent set of intra-operative images is deformably registered. The pre-operative MR image undergoes both rigid and deformation transformation to match specification of each image with in intra-operative MR image set.

摘要翻译： 公开了一种用于将术前磁共振（MR）图像与术中MR图像对准的系统和方法。 接收对象的术前MR图像。 接收对象的一组手术中MR图像。 手术前MR图像与初始手术中MR图像刚性对齐。 随后的一组术中图像可变形地记录。 手术前MR图像经历刚性和变形变换，以在手术中的MR图像组中匹配每个图像的规格。

公开(公告)号：US20050249398A1

公开(公告)日：2005-11-10

申请号：US11109119

申请日：2005-04-19

申请人： Ali Khamene ,  Frank Sauer ,  Chenyang Xu

发明人： Ali Khamene ,  Frank Sauer ,  Chenyang Xu

IPC分类号： A61K31/4439 ,  A61P9/00 ,  C07D401/14 ,  G06K9/00 ,  G06K9/32 ,  G06T7/00

CPC分类号： G06T7/38 ,  G06T2207/30004

摘要： Exemplary methods are provided. In one exemplary method, a lower-dimension signature is generated for each of a plurality of data sets of a given dimension. Registration is performed on the lower-dimension signatures. In another exemplary method, a two-dimensional signature is generated for each of a plurality of three-dimensional volumes. Registration is performed on the two-dimensional signatures.

摘要翻译： 提供了示例性方法。 在一个示例性方法中，为给定维度的多个数据集中的每一个产生较低维度签名。 对较低维的签名执行注册。 在另一示例性方法中，为多个三维体积中的每一个生成二维签名。 对二维签名执行注册。

公开(公告)号：US20050203380A1

公开(公告)日：2005-09-15

申请号：US11056317

申请日：2005-02-11

申请人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

发明人： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

IPC分类号： A61B5/05

CPC分类号： G02B7/002 ,  A61B34/10 ,  A61B34/20 ,  A61B90/20 ,  A61B90/36 ,  A61B90/361 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2072 ,  A61B2090/371 ,  G02B27/017 ,  G02B2027/0138 ,  G02B2027/0187 ,  G06F3/012

摘要： A method for augmented reality navigation of a medical intervention includes providing a stereoscopic head mounted display, the display including a pair of stereo viewing cameras, at least one tracking camera, and a stereoscopic guidance display. During a medical intervention on a patient, the patient's body pose is determined from a rigid body transformation between the tracking camera and frame markers on the scanning table, and the pose of an intervention instrument with respect to the table is determined. A visual representation of the patient overlaid with an image of the intervention target, the instrument, and a path for guiding the instrument to perform said medical intervention is displayed in the stereoscopic guidance display.

摘要翻译： 用于医疗干预的增强现实导航的方法包括提供立体头戴式显示器，所述显示器包括一对立体观看照相机，至少一个跟踪相机和立体指导显示器。 在患者的医疗干预中，患者的身体姿势由跟踪摄像机和扫描台上的帧标记之间的刚性身体变换确定，并且确定干预仪器相对于桌子的姿势。 在立体指导显示中显示覆盖有介入目标图像，仪器和用于引导仪器执行所述医疗干预的路径的患者的视觉表示。