-
公开(公告)号:US08426401B2
公开(公告)日:2013-04-23
申请号:US12765018
申请日:2010-04-22
申请人: Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人: Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号: A61K31/496 , C07D417/12 , C07D417/14
CPC分类号: C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
-
公开(公告)号:US08362001B2
公开(公告)日:2013-01-29
申请号:US12765487
申请日:2010-04-22
申请人: Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
发明人: Haiyan Bian , Kristen Chevalier , Jose Clemente , Pete Connolly , Chris Flores , Shu-Chen Lin , Li Liu , John Mabus , Mark Macielag , Mark McDonnell , Philip Pitis , Yue-Mei Zhang , Sui-Po Zhang , Bin Zhu
IPC分类号: A61K31/496 , A61K31/506 , A61K31/517 , C07D295/192 , C07D401/14 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号: C07D403/10 , C07D205/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
-
33.
公开(公告)号:US20120058986A1
公开(公告)日:2012-03-08
申请号:US13224654
申请日:2011-09-02
申请人: Peter J. Connolly , Mark J. Macielag , Bin Zhu
发明人: Peter J. Connolly , Mark J. Macielag , Bin Zhu
IPC分类号: A61K31/427 , A61K31/428 , C07D403/04 , A61K31/397 , C07D409/14 , C07D413/14 , A61K31/423 , C07D403/14 , A61K31/4035 , C07D401/14 , A61K31/454 , C07D513/04 , A61K31/429 , A61P29/00 , A61P1/00 , A61P25/06 , A61P19/02 , A61P21/00 , A61P17/00 , A61P1/02 , A61P17/02 , A61P13/10 , A61P31/00 , A61P11/02 , A61P17/04 , A61P11/00 , A61P1/18 , C07D417/14
CPC分类号: A61K31/397 , A61K31/4035 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/454 , C07D205/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式(I)表示如下:其中Q和Z在本文中定义。
-
公开(公告)号:US20090299875A1
公开(公告)日:2009-12-03
申请号:US12129701
申请日:2008-05-30
IPC分类号: G06Q30/00
CPC分类号: G06Q30/06 , G06Q30/0601
摘要: A system for facilitating online shopping that includes one or more content providers of a first domain, one or more online merchants of a second domain, and a framework. Web pages may be aggregated from the content providers. Descriptions of products for sale may be aggregated from the online merchants. The products for sale may be matched with the web pages based on relevancy. A list of descriptions of products that are relevant to each web page may be provided. A shopping cart list may be maintained by the framework. The shopping cart list may facilitate payment for the products for sale selected from different web pages.
摘要翻译: 一种用于促进在线购物的系统,其包括第一域的一个或多个内容提供商,第二域的一个或多个在线商家和框架。 可以从内容提供商聚合网页。 可以从在线商家汇总出售产品的描述。 出售的产品可能会根据相关性与网页匹配。 可以提供与每个网页相关的产品的描述的列表。 框架可以维护购物车列表。 购物车列表可以促进从不同网页选择的销售产品的支付。
-
35.
公开(公告)号:US20050250713A1
公开(公告)日:2005-11-10
申请号:US11114502
申请日:2005-04-26
申请人: Bin Zhu , Brett Marinelli , Mark Macielag
发明人: Bin Zhu , Brett Marinelli , Mark Macielag
IPC分类号: A61K31/7048 , C07H17/00 , C07H17/08
CPC分类号: C07H17/08
摘要: The present invention is directed to novel macrolide antibacterial agents and processes for preparing them. The present invention is further directed to pharmaceutical compositions containing the novel macrolide antibacterial agents disclosed herein and their use in the treatment and prevention of bacterial infections.
摘要翻译: 本发明涉及新型大环内酯类抗菌剂及其制备方法。 本发明进一步涉及含有本文所公开的新型大环内酯抗菌剂及其在治疗和预防细菌感染中的用途的药物组合物。
-
公开(公告)号:US06226387B1
公开(公告)日:2001-05-01
申请号:US08921931
申请日:1997-08-27
申请人: Ahmed H. Tewfik , Mitchell D. Swanson , Bin Zhu
发明人: Ahmed H. Tewfik , Mitchell D. Swanson , Bin Zhu
IPC分类号: G06K900
CPC分类号: G06T1/0085 , G06T1/0028 , G06T2201/0051 , G06T2201/0052 , G06T2201/0061 , G06T2201/0202 , H04N1/32154 , H04N1/3217 , H04N1/32192 , H04N19/117 , H04N19/132 , H04N19/154 , H04N19/172 , H04N19/176 , H04N19/179 , H04N19/63 , H04N21/23892 , H04N21/8358
摘要: A method and apparatus for the scene-based watermarking of video data is disclosed. In one embodiment, each of a number of frames of a scene of video host data undergoes a temporal wavelet transform, from which blocks are extracted. The blocks undergo perceptual masking in the frequency domain, such that a watermark is embedded therein. Once the watermark block is taken out of the frequency domain, a spatial mask of the original block is weighted to the watermark block, and added to the original block to obtain the watermarked block.
摘要翻译: 公开了一种用于视频数据的基于场景的水印的方法和装置。 在一个实施例中,视频主机数据的场景的多个帧中的每一个经历时间小波变换,从中提取块。 这些块在频域中进行感知掩蔽,使得嵌入水印。 一旦将水印块从频域中取出,将原始块的空间掩码加权到水印块,并将其加到原始块中以获得水印块。
-
37.
公开(公告)号:US20200247754A1
公开(公告)日:2020-08-06
申请号:US16341595
申请日:2017-10-09
申请人: Michael T. RUDD , Zhaoyang MENG , Jenny WAI , David Jonathan BENNETT , Edward J. BRNARDIC , Nigel J. LIVERTON , Shawn J. STACHEL , Yongxin HAN , Paul TEMPEST , Jiuxiang ZHU , Xuewang XU , Bin ZHU , Merck Sharp & Dohme Corp.
发明人: Michael T. Rudd , Zhaoyang Meng , Jenny Wai , David Jonathan Bennett , Edward J. Brnardic , Nigel J. Liverton , Shawn J. Stachel , Yongxin Han , Paul Tempest , Jiuxiang Zhu , Xuewang Xu , Bin Zhu
IPC分类号: C07D221/20 , C07D401/12 , C07D417/12 , C07D405/12 , C07D211/22 , C07D401/14 , C07D417/14
摘要: In its many embodiments, the present invention provides certain substituted aryl and heteroaryl ether compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, L, R4, L1, Q, and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
-
公开(公告)号:US09404644B1
公开(公告)日:2016-08-02
申请号:US15010593
申请日:2016-01-29
申请人: Jorge Perez-Bravo , Qinghua Xiao , Bin Zhu
发明人: Jorge Perez-Bravo , Qinghua Xiao , Bin Zhu
IPC分类号: F21V21/30 , F21V21/34 , F21V21/02 , F21V21/22 , F21V21/096 , G09F13/04 , G09F9/30 , G09F19/22 , G09F7/18 , G09F7/20 , G09F15/00 , F21S8/00 , F21Y105/00 , G09F9/302
CPC分类号: G09F9/3026 , F21S8/033 , F21S8/036 , F21V21/02 , F21V21/096 , F21V21/22 , F21V21/30 , F21V21/34 , F21Y2105/00 , G09F7/18 , G09F7/20 , G09F9/301 , G09F13/00 , G09F13/04 , G09F19/226 , G09F2007/1852 , Y10T29/49826 , Y10T29/4984
摘要: Display module mounting apparatus and methods provide mounting features enabling ease of installation and service. The apparatus may have one or more releasable frame couplers and pivoting releasable frame couplers coupled to a display module having a display plane defined in relation to a substrate. One or more adjustable linkages may adjustably define a standoff distance between the display plane and a support frame to which the module may be mounted by the mounting apparatus. Concave and convex adjustments to the display plane may be made. Operation of pivoting action to tilt the display plane enables installation, removal, and serviceability of large displays constructed with a tiled plurality of display modules.
-
公开(公告)号:US08859791B2
公开(公告)日:2014-10-14
申请号:US13878659
申请日:2011-10-11
申请人: Hua Li , Min Lin , Xiaoju Wu , Wei Wang , Chijian He , Jizao Gao , Xingtian Shu , Shuanghua Wan , Bin Zhu
发明人: Hua Li , Min Lin , Xiaoju Wu , Wei Wang , Chijian He , Jizao Gao , Xingtian Shu , Shuanghua Wan , Bin Zhu
IPC分类号: C07D301/12 , C07D303/04
CPC分类号: C07D301/12 , C07D303/04
摘要: A process for producing an alkylene oxide by olefin epoxidation, wherein said process comprises the steps of: (1) in a first olefin epoxidation condition, in the presence of a first solid catalyst, a first mixed stream containing a solvent, an olefin and H2O2 is subjected to an epoxidation in one or more fixed bed reactors and/or one or more moving bed reactors until the conversion of H2O2 reaches 50%-95%, then, optionally, the resulting reaction mixture obtained in the step (1) is subjected to a separation to obtain a first stream free of H2O2 and a second stream containing the unreacted H2O2, and the olefin is introduced to the second stream to produce a second mixed stream, or optionally, the olefin is introduced to the reaction mixture obtained in the step (1) to produce a second mixed stream; (2) in a second olefin epoxidation condition, the reaction mixture obtained in the step (1) or the second mixed stream obtained in the step (1) and a second solid catalyst are introduced to one or more slurry bed reactors to conduct an epoxidation until the total conversion of H2O2 reaches 98% or more, with a proviso that said process for producing the alkylene oxide by olefin epoxidation has an selectivity for the alkylene oxide of 90% or more.The process of the present invention combines the slurry bed reactor with the fixed bed reactor and/or the moving bed reactor so as to overcome the disadvantages of the low conversion of H2O2 in the case that only the fixed bed reactor and/or the moving bed reactor are used, and the low selectivity for the target alkylene oxide in the case that only the slurry bed reactor is used.
摘要翻译: 一种通过烯烃环氧化生产烯化氧的方法,其中所述方法包括以下步骤:(1)在第一烯烃环氧化条件下,在第一固体催化剂存在下,将含有溶剂,烯烃和H 2 O 2的第一混合物流 在一个或多个固定床反应器和/或一个或多个移动床反应器中进行环氧化,直到H 2 O 2的转化率达到50%-95%,然后,任选地,将在步骤(1)中获得的所得反应混合物 以分离以获得不含H 2 O 2的第一物流和含有未反应的H 2 O 2的第二物流,并将烯烃引入第二物流以产生第二混合物流,或任选地将烯烃引入到 步骤(1)以产生第二混合流; (2)在第二烯烃环氧化条件下,将步骤(1)中获得的反应混合物或步骤(1)中获得的第二混合物流和第二固体催化剂引入一个或多个淤浆床反应器中进行环氧化 直到H 2 O 2的总转化率达到98%以上,条件是通过烯烃环氧化生产环氧烷烃的方法对环氧烷烃的选择性为90%以上。 本发明的方法将淤浆床反应器与固定床反应器和/或移动床反应器结合,以克服在只有固定床反应器和/或移动床的情况下H 2 O 2转化率低的缺点 使用反应器,在仅使用浆料床反应器的情况下对目标烯化氧的选择性低。
-
公开(公告)号:US20140128428A1
公开(公告)日:2014-05-08
申请号:US14152006
申请日:2014-01-10
申请人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
发明人: Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Donald W. Ludovici , Mingde Xia , Xiaoqing Xu , Mark A. Youngman , Bin Zhu
IPC分类号: C07D217/04
CPC分类号: C07D217/04 , C07C237/20 , C07C2102/08 , C07C2602/08 , C07D215/38 , C07D217/02 , C07D401/12
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein A, L, R1, R2, R4, and R5 are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式(I)表示如下:其中A,L,R 1,R 2,R 4和R 5在本文中定义。
-
-
-
-
-
-
-
-
-