公开(公告)号：US10934383B2

公开(公告)日：2021-03-02

申请号：US16072605

申请日：2017-01-24

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： Michael R. Bockstaller ,  Amir Khabibullin ,  Zongyu Wang ,  Hangjun Ding ,  Guojun Xie ,  Krzysztof Matyjaszewski ,  Jiajun Yan ,  Zhao Lu

IPC: C08K3/22 ,  C08K3/36 ,  C08F292/00 ,  C08F293/00 ,  C08L39/00 ,  C08L35/00 ,  H01L33/56 ,  C08L83/04 ,  H01L33/64

Abstract: A composition formed by dispersing at least a plurality of first particles within a matrix material and dispersing at least a plurality of second particles within the matrix material, the second particles being different from the first particles, wherein interaction between the at least a plurality of second particles and the at least a plurality of first particles determines a spatial distribution of the plurality of second particles within the matrix material.

公开(公告)号：US20190099521A1

公开(公告)日：2019-04-04

申请号：US16095051

申请日：2017-04-13

Applicant: VALORISATION RECHERCHE, LIMITED PARTNERSHIP ,  VALORISATION HSJ, LIMITED PARTNERSHIP ,  CARNEGIE MELLON UNIVERSITY

Inventor： Xavier Banquy ,  Jimmy Faivre ,  Buddha Ratna Shrestha ,  Krzysztof Matyjaszewski ,  Joanna Burdynska ,  Florina Moldovan

IPC: A61L27/50 ,  A61L27/16 ,  A61L31/14 ,  A61L31/10 ,  C10M107/48 ,  C10M107/44 ,  C10M173/02

Abstract: A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

公开(公告)号：US20190031810A1

公开(公告)日：2019-01-31

申请号：US16072605

申请日：2017-01-24

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： Michael R. Bockstaller ,  Amir Khabibullin ,  Zongyu Wang ,  Hangjun Ding ,  Guojun Xie ,  Krzysztof Matyjaszewski ,  Jiajun Yan ,  Zhao Lu

IPC: C08F293/00 ,  C08F292/00 ,  C08L83/04 ,  C08K3/22 ,  C08K3/36

Abstract: A composition formed by dispersing at least a plurality of first particles within a matrix material and dispersing at least a plurality of second particles within the matrix material, the second particles being different from the first particles, wherein interaction between the at least a plurality of second particles and the at least a plurality of first particles determines a spatial distribution of the plurality of second particles within the matrix material.

公开(公告)号：US09982070B2

公开(公告)日：2018-05-29

申请号：US14993632

申请日：2016-01-12

Applicant: Carnegie Mellon University

Inventor： Krzysztof Matyjaszewski ,  Pawel Chmielarz ,  Dominik Konkolewicz ,  Pawel Krys ,  Xiangcheng Pan ,  Valerie Williams

IPC: C08F4/40 ,  C08F4/50 ,  C08F120/28 ,  C08F220/54

CPC classification number: C08F120/28 ,  C08F4/40 ,  C08F4/50 ,  C08F220/54 ,  C08F2438/01

Abstract: A process for polymerizing radically (co)polymerizable monomers at a temperature between −10° C. and 110° C. in an aqueous system comprising one or more radically (co)polymerizable monomer(s) is disclosed, and includes a molar excess of a ligand forming a soluble transition metal complex with an added transition metal salt that participates in a reversible reduction-oxidation cycle with one of an added site specific functional initiator and a dormant polymer chain having a radically transferable atom or group. The initial soluble catalyst complex concentration in the higher oxidation state is less than or equal to 2500 ppm. The reaction is conducted in the presence of an activator regenerator. The mole fraction of the soluble lower activator oxidation state transition metal formed by action of the activator regenerator, to transition metal in a higher deactivator oxidation state is less than 10%. The formed polymer chains have a dispersity of less than 1.5.

公开(公告)号：US20170152336A9

公开(公告)日：2017-06-01

申请号：US14785334

申请日：2014-04-17

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： SUBHA RANJAN DAS ,  SAADYAH AVERICK ,  SOURAV K. DEY ,  Krzysztof Matyjaszewski

IPC: C08F251/00

CPC classification number: C08F251/00 ,  C07H1/00 ,  C07H21/00

Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.

公开(公告)号：US20160075810A1

公开(公告)日：2016-03-17

申请号：US14785334

申请日：2014-04-17

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： SUBHA RANJAN DAS ,  SAADYAH AVERICK ,  SOURAV K. DEY ,  Krzysztof Matyjaszewski

IPC: C08F251/00

CPC classification number: C08F251/00 ,  C07H1/00 ,  C07H21/00

Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.

Abstract translation: 合成多核苷酸组合物的方法包括将固定在固相载体上的核苷酸链组装的末端固定在多核苷酸的固相合成期间将包含至少一种引发剂或至少一种用于可逆失活自由基聚合的转移剂的化合物 使得引发剂或转移剂以在多核苷酸去保护的条件下稳定的方式侵袭到核苷酸链组装的末端，并且通过经由链转移剂的位点从引发剂生长聚合物 可逆失活自由基聚合以形成多核苷酸组合物。

公开(公告)号：US20150275206A1

公开(公告)日：2015-10-01

申请号：US14418987

申请日：2013-08-01

Applicant: CARNEGIE MELLON UNIVERSITY

Inventor： Subha Ranjan Das ,  Eduardo Paredes ,  Saadyah Averick ,  Krzysztof Matyjaszewski

IPC: C12N15/113

CPC classification number: C12N15/113 ,  A61K47/58 ,  A61K47/64 ,  C12N15/87 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2320/51

Abstract: A delivery system for delivering oligonucleotides includes a conjugate includes a complexing agent including an oligonucleotide, a peptide nucleic acid or chimera thereof and a polymer covalently attached to the complexing agent. The complexing agent of the conjugate is adapted to complex a biologically active agent thereto after formation of the conjugate.

Abstract translation: 用于递送寡核苷酸的递送系统包括缀合物，其包括络合剂，其包括寡核苷酸，肽核酸或其嵌合体和共价连接到络合剂的聚合物。 缀合物的络合剂适于在形成缀合物之后将生物活性剂复合到其上。