摘要:
The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent,is the grouping ##STR3## an oxygen or sulfur atom, and Y and Z, independently of each other, are ##STR4## or a nitrogen atom, as well as their pharmaceutically compatible addition salts with acids as well as processes for production thereof. The compounds possess strongly aromatase-inhibiting activity and are suitable for the preparation of medicinal agents.Methods for treating estrogen induced or stimulated tumors, male infertility, and impending cardiac infarction with these compounds are also provided as well as methods for inhbiiting female fertility.
摘要:
11 .beta.-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping N OH,R.sup.1 is a hydrogen atom or a methyl group,R.sup.2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms,R.sup.3 is a hydrogen atom, the cyanomethyl group, --(CH.sub.2).sub.n --, CH.sub.2 Z, --CH.dbd.CH--(CH.sub.2).sub.m Z or --C.tbd.C--Y wherein n=0 to 5 and m=1 to 4, Z meaning a hydrogen atom or the OR.sup.4 group with R.sup.4 meaning a hydrogen atom, an alkyl or alkanoyl group each of 1-4 carbon atoms, and Y meaning a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group each of 1-4 carbon atoms in the alkyl or acyl residue, possess antiprogestational activity.
摘要:
11.beta.-Arylestradienes of general Formula I are disclosed ##STR1## wherein R.sup.2 is a hydrogen atom, a methyl group, or an ethyl group,R.sup.3 is a hydrogen atom or an acyl group,R.sup.1 and A-B have various meanings,which possess antigestagen and antimineralocorticoid activity.
摘要:
In a munitions system, a cylindrical canister is fired over a target. The canister carries a target sensing infrared device and, when a target is detected, a projectile is fired downward from the bottom of the overflying missile. A spinning motion is imparted to the missile to stabilize its flight, and a wobbling motion is imparted to the missile to provide a larger target area. The projectile forms a concave lower end to the missile and is fired by an explosive charge.
摘要:
An ultrasonic liquid film cleaning device having means for moving a film strip at high speeds between a pair of oppositely moving cleaning strips. The cleaning strips and the film are positioned for movement between a pair of beds which act as guides and compression surfaces for the sandwiched assembly of cleaning strips and film. Cleaning fluid is piped to the bed to wet the cleaning strips and thereby assist in the cleaning action. An ultrasonic device is mounted in each bed to activate the fluid which is absorbed by the cleaning strips. This activation of the fluid increases the cleaning power of the strips as they pass against the film.
摘要:
A joint support is adapted to be disposed beneath a joint at adjacent ends of horizontally disposed overlapping siding panels to support same and to assist in preventing the formation of a gap at said joint by virtue of inward buckling or deflection of one of the panels relative to the other. The joint support, as seen in a cross-section view taken at right angles to the longitudinal dimension of the panels in the installed condition has a wedge taper and has minimum thickness adjacent a first end which, in use, is uppermost. The opposite end of the joint support is contoured or shaped to overlie and accommodate the panel holding lip of a preceding lower panel. The first end of the joint support has an outwardly and downwardly turned portion adapted to fit over the panel holding lip or lips of the panels which the joint support, in use, underlies and the opposite end of the joint support includes shallow hook means thereon for snap fitting engagement over the holding lip of the preceding lower panel.
摘要:
A vertically stackable and retrofittable traffic cone linking system having a plurality of linking cuffs substantially conically shaped linking cuffs having four connection points, sized and configured to be removably secured to a standard traffic cone and a traffic cone linking connector removably connected to the linking cuffs. Once the traffic cone linking cuff is linked to the traffic cone linking connector, the traffic cone linking system can be can be arranged in a predetermined configuration or arrangement to alert onlookers of a particular hazard or to impede access to a given location.
摘要:
A luminaire includes a heat spreader; a heat sink; an LED light source; a power supply; an electrical supply line having a first end connected to the power supply, and a second end connected to a plug-in connector; and, an optic securely retained relative to the heat spreader or heat sink. An accessory kit includes a first pre-wired jumper including a pair of insulated electrical wires having a first plug-in connector electrically connected at one end and an Edison base electrically connected at the other end; and/or, a second pre-wired jumper including a pair of insulated electrical wires having a second plug-in connector electrically connected at one end and unconnected wire ends at the other end. The plug-in connector of the first pre-wired jumper and the second pre-wired jumper are each configured to electrically engage with the plug-in connector of the electrical supply line.
摘要:
A luminaire includes an electrical base, an optic, and a heat sink disposed between the base and the optic. The lens has a first curved portion, a second curved portion and a third portion. An LED light source is coupled to the heat sink with LED modules arranged to direct light in the same direction. A frustoconical member having a reflective outer surface is disposed between the lens and the LED light source wherein the LED light source has LED modules disposed to emit at least a portion of light toward the reflective outer surface such that light is emitted with a substantially even luminous intensity in a 0°-135° zone.