公开(公告)号：US06913917B2

公开(公告)日：2005-07-05

申请号：US09940727

申请日：2001-08-28

申请人： Donald W. Landry

发明人： Donald W. Landry

IPC分类号： C12N15/09 ,  A61K38/00 ,  C12N9/00 ,  A61K38/43

CPC分类号： C12N9/0002 ,  A61K38/00

摘要： Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration and a method for decreasing the concentration of cocaine of a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.

摘要翻译： 公开了能够降解可卡因的催化抗体和多肽。 所述催化抗体和多肽的特征在于其互补决定区和框架区的氨基酸序列。 本发明还公开了降低浓度的药物组合物和方法以及降低受试者可卡因浓度的方法。 最后，本发明公开了治疗可卡因过量和成瘾的药物组合物和方法。

公开(公告)号：US06620120B2

公开(公告)日：2003-09-16

申请号：US09083781

申请日：1998-05-22

申请人： Donald W. Landry ,  Howard R. Levin ,  Evan Stuart Garfein

发明人： Donald W. Landry ,  Howard R. Levin ,  Evan Stuart Garfein

IPC分类号： A61M3500

CPC分类号： A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3458

摘要： Disclosed herein is an apparatus that efficiently clears solutes from blood of patients with renal disease solely by convection and with a single filter that includes a hemofilter, a blood pump for drawing blood from a patient and propelling the blood into a mixing chamber, a mixing and detention chamber where the blood and a non-isosmotic diluent are mixed and are allowed to approach or reach equilibrium (with regard to solute concentration), a mixing element for creating turbulence in the mixing/detention chamber, and suitable tubing for carrying the pumped blood to and from the patent. Methods for utilizing the apparatus are also disclosed.

摘要翻译： 本文公开了一种能够仅通过对流有效地从具有肾脏疾病的患者的血液中清除溶质的装置，以及包括血液滤过器的单个过滤器，用于从患者抽取血液并将血液推进混合室的血泵，混合和 血液和非等渗稀释剂混合并被允许接近或达到平衡（关于溶质浓度）的拘留室，用于在混合/滞留室中产生湍流的混合元件，以及用于携带泵送血液的适当管道 来自专利。 还公开了利用该装置的方法。

公开(公告)号：US06566084B1

公开(公告)日：2003-05-20

申请号：US09567021

申请日：2000-05-09

申请人： Donald W. Landry ,  Kang Zhao

发明人： Donald W. Landry ,  Kang Zhao

IPC分类号： G01N3353

CPC分类号： C07D451/02 ,  A61K38/00 ,  A61K47/6803 ,  C07F9/6561 ,  C07F9/657172 ,  C07F9/6584 ,  C07K16/44 ,  C12N9/0002

摘要： This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmaceutical composition for decreasing cocaine concentration in a subject using the antibodies produced.

摘要翻译： 本发明提供了类似于可卡因苯甲酰酯基的水解转变状态的化合物。 本发明还提供了与载体蛋白质及其抗体连接的类似物。 本发明还提供了使用所产生抗体降低受试者中可卡因浓度的药物组合物。

公开(公告)号：US20210047337A1

公开(公告)日：2021-02-18

申请号：US17085791

申请日：2020-10-30

申请人： Konstantin Petrukhin ,  Kirsten Alison Rinderspacher ,  Shi-Xian Deng ,  Andras Varadi ,  Boglarka Racz ,  Peter Bernstein ,  Patricia C. Weber ,  Donald W. Landry ,  Andrew S. Wasmuth

发明人： Konstantin Petrukhin ,  Kirsten Alison Rinderspacher ,  Shi-Xian Deng ,  Andras Varadi ,  Boglarka Racz ,  Peter Bernstein ,  Patricia C. Weber ,  Donald W. Landry ,  Andrew S. Wasmuth

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P27/02

摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3, C1-C4 alkyl, aryl or heteroaryl; X is N or CR6, wherein R6 is H, OH, or halogen; A is absent or present, and when present is B has the structure: or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20170106056A1

公开(公告)日：2017-04-20

申请号：US15390514

申请日：2016-12-25

申请人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovic ,  John J. Tesmer ,  Remy L. Brim

发明人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovic ,  John J. Tesmer ,  Remy L. Brim

IPC分类号： A61K38/46 ,  C12N9/18 ,  C12Q1/44 ,  A61K9/00

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K31/505 ,  A61K45/06 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  C12N9/18 ,  C12Q1/44 ,  C12Y301/01084 ,  G01N2333/918 ,  A61K2300/00

摘要： Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

公开(公告)号：US09107868B2

公开(公告)日：2015-08-18

申请号：US13569510

申请日：2012-08-08

申请人： Richard Ambron ,  Ying-Ju Sung ,  Donald W. Landry ,  Shi-Xian Deng

发明人： Richard Ambron ,  Ying-Ju Sung ,  Donald W. Landry ,  Shi-Xian Deng

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/04 ,  A61K38/02 ,  A61K38/06 ,  A61K38/07 ,  A61K47/48 ,  A61K38/46 ,  A61K31/352 ,  A61K31/4422 ,  C12N9/12 ,  A61K9/70

CPC分类号： A61K38/06 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/352 ,  A61K31/4422 ,  A61K31/55 ,  A61K38/02 ,  A61K38/07 ,  A61K38/465 ,  A61K47/64 ,  C12N9/1205 ,  C12Y301/04017

摘要： The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.

摘要翻译： 本发明涉及发现涉及感觉神经元的长期兴奋性的新型分子途径，其在高等动物中与持续性疼痛相关。 它是基于这样的发现：在神经元轴突损伤之后，一氧化氮合酶活性的增加导致一氧化氮产生增加，这反过来激活鸟苷酸环化酶，从而增加cGMP的水平。 增加的cGMP导致蛋白激酶G（“PKG”）的激活，其然后沿着轴突逆行转运到神经元细胞体，其中磷酸化MAPKerk。

公开(公告)号：US20140348813A1

公开(公告)日：2014-11-27

申请号：US14166619

申请日：2014-01-28

申请人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovich ,  John J. Tesmer ,  Remy L. Brim

发明人： Donald W. Landry ,  James H. Woods ,  Roger K. Sunahara ,  Diwahar L. Narasimhan ,  Joanne MacDonald ,  Milan N. Stojanovich ,  John J. Tesmer ,  Remy L. Brim

IPC分类号： A61K47/22 ,  C12Q1/44 ,  A61K47/18 ,  A61K38/46 ,  A61K47/12

CPC分类号： A61K38/465 ,  A61K9/0019 ,  A61K31/505 ,  A61K45/06 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K47/542 ,  A61K47/545 ,  A61K47/60 ,  C12N9/18 ,  C12Q1/44 ,  C12Y301/01084 ,  G01N2333/918 ,  A61K2300/00

摘要： Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

摘要翻译： 提供了包含可卡因酯酶（CocE）和使CocE稳定化合物的组合物。 还提供了热稳定可卡因酯酶的方法。 另外提供了治疗经历可卡因诱导病症的哺乳动物的方法。 还提供了确定化合物是否是蛋白质的热稳定剂的方法。 另外提供了上述用于治疗可卡因诱导病症的组合物的用途。 另外提供了编码具有取代L169K和G173Q的CocE多肽和由该核酸编码的CocE多肽的分离的核酸及其药物组合物。 还提供了该组合物用于制备用于治疗可卡因诱导的病症和用于治疗可卡因诱导病症的药物的用途。

公开(公告)号：US08697875B2

公开(公告)日：2014-04-15

申请号：US13167540

申请日：2011-06-23

申请人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

发明人： Yan Feng ,  Ottavio Arancio ,  Shixian Deng ,  Donald W. Landry

IPC分类号： A61P25/00 ,  A61P25/28 ,  C07D215/44

CPC分类号： A61K31/4706 ,  C07D215/48 ,  C07D215/54

摘要： The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.

摘要翻译： 本发明提供了磷酸二酯酶抑制剂的化合物。 本发明进一步提供了一种筛选结合并调节磷酸二酯酶蛋白质的化合物的方法。 本发明还提供了通过向受试者施用磷酸二酯酶结合化合物来治疗与累积的淀粉样蛋白-β肽沉积物积累相关的病症的方法。

公开(公告)号：US08653273B2

公开(公告)日：2014-02-18

申请号：US13178117

申请日：2011-07-07

申请人： Kirsten Alison Rinderspacher ,  Donald W. Landry ,  Yuli Xie ,  Yidong Liu ,  Gangli Gong ,  Shi-Xian Deng

发明人： Kirsten Alison Rinderspacher ,  Donald W. Landry ,  Yuli Xie ,  Yidong Liu ,  Gangli Gong ,  Shi-Xian Deng

IPC分类号： C07D211/62

CPC分类号： C07D211/96 ,  C07D211/62 ,  C07D401/12 ,  C07D409/12 ,  C07F9/59 ,  C12N9/99

摘要： The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (sEH). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells. In particular non-limiting embodiments, components of the invention may be used to treat hypertension.

摘要翻译： 本发明涉及通过抑制可溶性环氧化物水解酶（sEH）的活性而显示血管扩张和抗炎作用的化合物。 本发明还涉及鉴定这些化合物的方法，以及这些化合物用于治疗与血管舒张功能障碍，炎症和/或内皮细胞相关的疾病的用途。 特别是非限制性实施方案，本发明的组分可用于治疗高血压。

公开(公告)号：US08252754B2

公开(公告)日：2012-08-28

申请号：US11385455

申请日：2006-03-21

申请人： Richard Ambron ,  Ying-Ju Sung ,  Donald W. Landry ,  Shi-Xian Deng

发明人： Richard Ambron ,  Ying-Ju Sung ,  Donald W. Landry ,  Shi-Xian Deng

IPC分类号： C12N15/11 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K38/06 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/352 ,  A61K31/4422 ,  A61K31/55 ,  A61K38/02 ,  A61K38/07 ,  A61K38/465 ,  A61K47/64 ,  C12N9/1205 ,  C12Y301/04017

摘要： The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.

摘要翻译： 本发明涉及发现涉及感觉神经元的长期兴奋性的新型分子途径，其在高等动物中与持续性疼痛相关。 基于这样的发现，在神经元轴突损伤之后，一氧化氮合酶活性的增加导致一氧化氮产生增加，这反过来激活鸟苷酸环化酶，从而增加cGMP的水平。 增加的cGMP导致蛋白激酶G（“PKG”）的激活，其然后沿着轴突逆行转运到神经元细胞体，其中磷酸化MAPKerk。