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110 条记录 (耗时 0.064 秒)

    Bicyclic heterocyclic derivatives and methods of use thereof
    33.
    发明授权
    Bicyclic heterocyclic derivatives and methods of use thereof 失效
    双环杂环衍生物及其使用方法

    公开(公告)号：US08283360B2

    公开(公告)日：2012-10-09

    申请号：US13139656

    申请日：2009-12-18

    申请人： Anandan Palani ,  Ashwin U. Rao ,  Xiao Chen ,  Ning Shao ,  Ying R. Huang ,  Robert G. Aslanian

    发明人： Anandan Palani ,  Ashwin U. Rao ,  Xiao Chen ,  Ning Shao ,  Ying R. Huang ,  Robert G. Aslanian

    IPC分类号： A61K31/437 ,  C07D498/04

    CPC分类号： C07D513/04 ,  C07D498/04

    摘要： The present invention relates to novel Bicyclic Heterocyclic Derivatives, pharmaceutical compositions comprising the Bicyclic Heterocyclic Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a cognitive disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.

    摘要翻译： 本发明涉及新型双环杂环衍生物，包含双环杂环衍生物的药物组合物和这些化合物用于治疗或预防治疗过敏，过敏诱发的气道反应，充血，心血管疾病，炎性疾病，胃肠道疾病 糖尿病，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。

    BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF
    35.
    发明申请
    BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
    双相PYRANONE衍生物及其使用方法

    公开(公告)号：US20110243940A1

    公开(公告)日：2011-10-06

    申请号：US13139890

    申请日：2009-12-15

    申请人： Dong Xiao ,  Anandan Palani ,  Xianhai Huang ,  Xiaohong Zhu ,  Robert G. Aslanian

    发明人： Dong Xiao ,  Anandan Palani ,  Xianhai Huang ,  Xiaohong Zhu ,  Robert G. Aslanian

    IPC分类号： A61K39/395 ,  C07D491/052 ,  A61K31/435 ,  A61K31/505 ,  A61K31/47 ,  A61K31/397 ,  A61K31/60 ,  A61K31/4162 ,  A61P3/10 ,  A61P35/00 ,  A61P11/00 ,  A61P1/00 ,  A61P25/00 ,  A61P3/04

    CPC分类号： C07D491/052

    摘要： The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complication, obesity, an obesity-related disorder or non-alcoholic fatty liver disease. Formula (I). Y is —C— when an optional and additional bond is present and Y is —CH— when an optional and additional bond is not present; Z is —O—, —NH— or —N(alkyl)- when the optional and additional bond between Y and Z Is absent, and Z Is —N— when the optional and additional bond between Y and Z is present; R1 is H1 halo or —CN; R2 is alkyl, alkenyl or -(alkyleneVcydoalkyl; t is 0 or 1; R3 is O when the optional and additional bond between Y and R3 is present, and R3 is alkyl.haloalkyl.—C(0)0R5.-alkylene-O-alkyt or —O-alkyl when the optional and additional bond between Y and R3 is absent: R4 is H, alkyl or aryl, wherein an aryl group can be unsubstituted or optionally substituted.

    摘要翻译： 本发明涉及双环吡喃酮衍生物，其组合物和用于治疗或预防代谢紊乱，血脂异常，心血管疾病，神经障碍，血液病，癌症，炎症，呼吸系统疾病，胃肠病，糖尿病， 糖尿病并发症，肥胖症，肥胖相关障碍或非酒精性脂肪性肝病。 式（I）。 当不存在任选和另外的键时，当存在任选的附加键且Y是-CH-时，Y是-C-; 当Y和Z之间的任选和另外的键不存在时，Z是-O - ， - NH-或-N（烷基），当存在Y和Z之间的任选的和另外的键时，Z是 - R1为H1卤素或-CN; R 2是烷基，烯基或 - （亚烷基二烷基; t是0或1;当存在Y和R 3之间的任选和另外的键时，R 3是O，R 3是烷基卤代烷基-C（O） - 烷基或-O-烷基，当Y和R3之间的任选和另外的键不存在时：R4是H，烷基或芳基，其中芳基可以是未取代的或任选被取代的。