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公开(公告)号:US07834029B2
公开(公告)日:2010-11-16
申请号:US11782659
申请日:2007-07-25
IPC分类号: A61K31/04 , C07D215/38
CPC分类号: C07D487/04 , A61K31/4709
摘要: A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
摘要翻译: 根据式II的化合物及其药学上可接受的盐以及通过施用所述化合物在有需要的患者中治疗癌症的方法。
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公开(公告)号:US07265225B2
公开(公告)日:2007-09-04
申请号:US10531237
申请日:2003-11-10
IPC分类号: C07D215/38 , A61K31/47
CPC分类号: C07D487/04 , A61K31/4709
摘要: A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
摘要翻译: 根据式II的化合物及其药学上可接受的盐以及通过施用所述化合物在有需要的患者中治疗癌症的方法。
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公开(公告)号:US06992100B2
公开(公告)日:2006-01-31
申请号:US10450745
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
IPC分类号: A61K31/403 , C07D209/56
CPC分类号: A61K31/403 , A61K31/407 , A61K31/4745
摘要: A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新的四环化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号:US08436002B2
公开(公告)日:2013-05-07
申请号:US13391895
申请日:2010-10-20
申请人: Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, Jr. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
发明人: Douglas Wade Beight , Timothy Paul Burkholder , Joshua Ryan Clayton , MariJean Eggen , Kenneth James Henry, Jr. , Deidre Michelle Johns , Saravanan Parthasarathy , Huaxing Pei , Mark Edward Rempala , Jason Scott Sawyer
IPC分类号: A01N43/54 , A01N43/90 , A01N43/42 , A01N43/40 , A61K31/517 , A61K31/519 , A61K31/44 , A61K31/445
CPC分类号: C07D471/04 , A61K31/519 , C07D487/04
摘要: The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
摘要翻译: 本发明提供下式的AKT抑制剂:式I本发明还提供包含式I化合物的药物组合物,式I化合物的用途和使用式I化合物的方法。
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公开(公告)号:US06930123B2
公开(公告)日:2005-08-16
申请号:US10450929
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/403 , A61P1/04 , A61P3/00 , A61P3/12 , A61P5/06 , A61P5/18 , A61P7/00 , A61P7/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P21/00 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/08 , A61P43/00 , C07D209/60 , A61K31/40 , C07D209/56
CPC分类号: C07D209/60
摘要: A novel class of benz[f]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新颖的苯并[f]吲哚化合物以及这些化合物用于抑制脂肪酸介导的释放脂肪酸用于治疗炎性疾病如败血性休克的用途。
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公开(公告)号:US06177440B1
公开(公告)日:2001-01-23
申请号:US09063066
申请日:1998-04-21
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: A61K3144
CPC分类号: C07D209/88
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号:US07511065B2
公开(公告)日:2009-03-31
申请号:US10535061
申请日:2003-11-12
申请人: Theodore Goodson, Jr. , Mary Margaret Mader , John Eldon Toth , Arindam Chatterjee , Jason Scott Sawyer
发明人: Theodore Goodson, Jr. , Mary Margaret Mader , John Eldon Toth , Arindam Chatterjee , Jason Scott Sawyer
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.
摘要翻译: 本发明提供下式的化合物:(式I); 其药物组合物包含有效量的式I化合物与合适的载体,稀释剂或赋形剂的组合,以及用于治疗生理障碍,特别是充血性心脏病的方法,包括向其中的患者施用 有效量的式I化合物。
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38.
公开(公告)号:US08063212B2
公开(公告)日:2011-11-22
申请号:US12516251
申请日:2007-12-11
申请人: Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
发明人: Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong-Yu Li , Jason Scott Sawyer , Yan Wang
IPC分类号: C07D401/00
CPC分类号: C07D409/14
摘要: The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N-ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3-trifluoro-propylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2-cyanoethylaminomethyl, morpholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1-azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or pharmaceutically acceptable salt thereof.
摘要翻译: 本发明提供了被认为具有通过抑制Plk1治疗癌症的临床用途的新型咪唑烷基氨基嘧啶化合物。 式(I)其中:R1是氨基甲基,(C1-C3烷基)氨基甲基,二(C1-C2烷基)氨基甲基,N-乙基-N-甲基 - 氨基甲基,1-氨基乙基,1-((C1-C2烷基)氨基) 乙基,3,3,3-三氟 - 丙氨基甲基,乙炔基,2-羟基 - 乙氧基,2-羟乙基氨基甲基,2-氰乙基氨基甲基,吗啉-4-基甲基,甲氧基甲氧基甲基,环丙基,1-氮杂环丁基甲基,1-吡咯烷基甲基, 3-二氧戊环-2-基; R2是氢或卤素; R3是氢或卤素; R2和R3中的至少一个是氢; R4是氢,甲基或卤素; 并且是存在或不存在的单键或其药学上可接受的盐。
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公开(公告)号:US06911542B2
公开(公告)日:2005-06-28
申请号:US10297682
申请日:2001-05-15
申请人: Mark W. Orme , Jason Scott Sawyer , Lisa M. Schultze , Alain Claude-Marie Daugan , Francoise Gellibert
发明人: Mark W. Orme , Jason Scott Sawyer , Lisa M. Schultze , Alain Claude-Marie Daugan , Francoise Gellibert
IPC分类号: C07D453/02 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P1/04 , A61P1/14 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/08 , A61P11/16 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P19/10 , A61P27/06 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07D471/14 , C07D519/00
CPC分类号: C07D471/14
摘要: Compounds of the general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents.
摘要翻译: 一般结构式(I)的化合物及其化合物及其盐和溶剂化物的用途作为治疗剂。
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公开(公告)号:US20100130466A1
公开(公告)日:2010-05-27
申请号:US12596957
申请日:2008-05-07
申请人: Harold Burns Brooks , Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
发明人: Harold Burns Brooks , Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
IPC分类号: A61K31/506 , C07D409/14 , A61P35/00 , C07D413/14 , A61K31/5377
CPC分类号: C07D409/14
摘要: The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译: 本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。
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