公开(公告)号：US11701351B2

公开(公告)日：2023-07-18

申请号：US17223422

申请日：2021-04-06

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K9/00 ,  A61K31/4745 ,  A61N5/10

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10 ,  A61K31/495 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.

公开(公告)号：US11660286B2

公开(公告)日：2023-05-30

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10

CPC classification number: A61K31/397 ,  A01N1/0226 ,  A61K31/12 ,  A61K31/16 ,  A61K31/198 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/40 ,  A61K31/445 ,  A61K33/00 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/6445 ,  A61N5/10 ,  Y02A50/30 ,  A61K33/00 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/445 ,  A61K2300/00 ,  A61K31/12 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/255 ,  A61K2300/00 ,  A61K31/16 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20210244870A1

公开(公告)日：2021-08-12

申请号：US17251552

申请日：2019-06-11

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Scott Caroen ,  Tony R. Reid ,  Corey Carter ,  Jeannie Williams

IPC: A61M1/34 ,  A61M1/38 ,  A61M1/36

Abstract: Devices, systems, and methods for medication infusion are described herein. In some embodiments, a system includes a patient access subassembly, a first fluid reservoir, a second fluid reservoir, and an assembly. The assembly can have a first configuration in which the patient access subassembly is in fluid communication with the first fluid reservoir via a first tube, a second configuration in which the first fluid reservoir is in fluid communication with the second fluid reservoir, and a third configuration in which the first fluid reservoir is in fluid communication with the patient access subassembly via a second tube, the first fluid reservoir fluidically isolated from the first tube in the third configuration.

公开(公告)号：US20200375982A1

公开(公告)日：2020-12-03

申请号：US16712148

申请日：2019-12-12

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K9/00 ,  A61K31/4745

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.

公开(公告)号：US20200022952A1

公开(公告)日：2020-01-23

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US09987270B1

公开(公告)日：2018-06-05

申请号：US15337378

申请日：2016-10-28

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.

公开(公告)号：US20180134766A1

公开(公告)日：2018-05-17

申请号：US15717199

申请日：2017-09-27

Applicant: EpicentRx, Inc.

Inventor： Christopher Larson ,  Tony R. Reid ,  Bryan T. Oronsky

IPC: C07K14/71 ,  C07K16/00 ,  A61K35/768 ,  C12N7/00 ,  A61P35/00

CPC classification number: C07K14/71 ,  A61K35/768 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07K16/00 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/76 ,  C07K2319/01 ,  C07K2319/30 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10332 ,  C12N2710/10333 ,  C12N2710/10343 ,  C12N2710/10371

Abstract: Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., a TGFβ trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion proteins, or expression vectors encoding for the fusion proteins, e.g., oncolytic adenoviral expression vectors, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.

公开(公告)号：US20160081981A1

公开(公告)日：2016-03-24

申请号：US14849783

申请日：2015-09-10

Applicant: EpicentRx, Inc.

Inventor： JAN SCICINSKI ,  Bryan T. Oronsky

IPC: A61K31/397 ,  A61N5/10 ,  A61K38/05

CPC classification number: A61K31/397 ,  A61K31/19 ,  A61K31/198 ,  A61K31/215 ,  A61K31/337 ,  A61K38/05 ,  A61K45/06 ,  A61N5/10 ,  C07D205/04

Abstract: The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof.

Abstract translation: 本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。 本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。