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公开(公告)号：US07939611B2
公开(公告)日：2011-05-10
申请号：US11176638
申请日：2005-07-07
IPC分类号： C08F28/06 , C08F26/06 , C08F130/02 , C08F14/04
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
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公开(公告)号：US20070061004A1
公开(公告)日：2007-03-15
申请号：US11580645
申请日：2006-10-13
申请人： Thomas Steinke , Donald Koenig , Joan Zeltinger
发明人： Thomas Steinke , Donald Koenig , Joan Zeltinger
IPC分类号： A61F2/94
CPC分类号： A61F2/92 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2/93 , A61F2/94 , A61F2002/072 , A61F2002/075 , A61F2002/91533 , A61F2002/9155 , A61F2002/91591 , A61F2220/005 , A61F2220/0058 , A61F2250/0067 , A61F2250/0098 , A61L31/16 , A61L2300/416 , B33Y80/00
摘要： The present invention provides a lumen support stent with a clear through-lumen for use in a body lumen. The stent is formed from at least one series of sliding and locking radial elements and at least one ratcheting mechanism comprising an articulating element and a plurality of stops. The ratcheting mechanism permits one-way sliding of the radial elements from a collapsed diameter to an expanded diameter, but inhibits radial recoil from the expanded diameter.
摘要翻译： 本发明提供了一种具有用于体腔内的透明通管的管腔支架。 支架由至少一系列滑动和锁定的径向元件形成，并且至少一个棘轮机构包括铰接元件和多个止动件。 棘轮机构允许径向元件从塌缩直径单向滑动到扩张直径，但是抑制从扩张直径的径向反冲。
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公开(公告)号：US07118746B1
公开(公告)日：2006-10-10
申请号：US09979813
申请日：2000-05-12
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
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公开(公告)号：US08138147B2
公开(公告)日：2012-03-20
申请号：US12349451
申请日：2009-01-06
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。 另外，细胞可以被遗传修饰。 优选三维组织构建体。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中 通过侵入性手术加快缝合线愈合。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US08124700B2
公开(公告)日：2012-02-28
申请号：US13101504
申请日：2011-05-05
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
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36.发明申请METHODS FOR USING A THREE-DIMENSIONAL STROMAL TISSUE TO PROMOTE ANGIOGENESIS 审中-公开使用三维结构组织促进血管生成的方法公开(公告)号：US20110213470A1
公开(公告)日：2011-09-01
申请号：US12981260
申请日：2010-12-29
IPC分类号： A61F2/02
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3839 , A61L27/507
摘要： The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.
摘要翻译： 本发明涉及促进组织器官中血管形成的方法。 特别地，该方法涉及植入或附着工程化的三维基质组织以促进心脏和相关组织中的内皮细胞化和血管发生。 本发明的三维基质组织可用于多种应用，包括但不限于促进损伤的心肌的修复和再生，促进心脏手术期间的血管化和愈合，促进吻合部位的血管形成 并促进损伤的骨骼肌，平滑肌或结缔组织的血管化和修复。
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公开(公告)号：US20110213090A1
公开(公告)日：2011-09-01
申请号：US13101504
申请日：2011-05-05
IPC分类号： C08G63/685 , C08F212/14 , C08G77/24 , C08F299/00 , C08G77/44 , C08F220/06
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
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公开(公告)号：US20110212050A1
公开(公告)日：2011-09-01
申请号：US13101499
申请日：2011-05-05
IPC分类号： A61K31/785 , C08G77/24 , C08F212/14 , C08G63/685 , A61P29/00 , A61P17/02 , A61P35/00
CPC分类号： C08G64/10 , A61B17/12022 , A61B17/12036 , A61B17/12145 , A61B17/12186 , A61K31/74 , A61K33/18 , A61K45/06 , A61K49/0442 , A61K49/0476 , A61L24/0042 , A61L31/148 , A61L31/18 , C08F220/18 , C08G63/68 , C08G63/6826 , C08G63/6856 , C08G63/6886 , C08G63/916 , C08G64/12 , C08G64/42 , C08G65/40 , C08G77/24 , C08G2261/126 , A61K2300/00
摘要： Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
摘要翻译： 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。
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39.发明申请公开(公告)号：US20090269316A1
公开(公告)日：2009-10-29
申请号：US12420716
申请日：2009-04-08
CPC分类号： A61L27/3886 , A61L27/3804 , A61L27/3839 , A61L27/507
摘要： The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.
摘要翻译： 本发明涉及促进组织器官中血管形成的方法。 特别地，该方法涉及植入或附着工程化的三维基质组织以促进心脏和相关组织中的内皮细胞化和血管发生。 本发明的三维基质组织可用于多种应用，包括但不限于促进损伤的心肌的修复和再生，促进心脏手术期间的血管化和愈合，促进吻合部位的血管形成 并促进损伤的骨骼肌，平滑肌或结缔组织的血管化和修复。
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