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    EXPANDABLE STENT WITH SLIDING AND LOCKING RADIAL ELEMENTS
    1.
    发明申请
    EXPANDABLE STENT WITH SLIDING AND LOCKING RADIAL ELEMENTS 审中-公开
    具有滑动和锁定径向元素的可扩展的支架

    公开(公告)号：US20070142901A1

    公开(公告)日：2007-06-21

    申请号：US11680532

    申请日：2007-02-28

    申请人： Thomas Steinke ,  Donald Koenig ,  Joan Zeltinger

    发明人： Thomas Steinke ,  Donald Koenig ,  Joan Zeltinger

    IPC分类号： A61F2/94

    CPC分类号： A61F2/94 ,  A61F2002/825 ,  A61F2220/005 ,  A61F2220/0058

    摘要： In preferred embodiments, this invention relates to an expandable stent, comprising a tubular member comprising at least two circumferentially-adjacent radial elements, wherein each radial element comprises an engagement slot, through which a portion of the circumferentially-adjacent radial element is slidably engaged, such that the tubular member is capable of expanding from a first collapsed diameter to a second expanded diameter, wherein the engagement slot is not a paired slot.

    摘要翻译： 在优选实施例中，本发明涉及一种可扩张支架，其包括管状构件，其包括至少两个周向相邻的径向元件，其中每个径向元件包括接合槽，所述周向相邻的径向元件的一部分可滑动地接合在所述接合槽中， 使得管状构件能够从第一塌缩直径扩展到第二扩展直径，其中接合槽不是成对的狭槽。

    Methods for using a three-dimensional stromal tissue to promote angiogenesis
    3.
    发明授权
    Methods for using a three-dimensional stromal tissue to promote angiogenesis 有权
    使用三维基质组织促进血管发生的方法

    公开(公告)号：US08128924B2

    公开(公告)日：2012-03-06

    申请号：US12420716

    申请日：2009-04-08

    申请人： Gail K. Naughton ,  Jonathan Noel Mansbridge ,  Robert Emmett Pinney ,  Joan Zeltinger

    发明人： Gail K. Naughton ,  Jonathan Noel Mansbridge ,  Robert Emmett Pinney ,  Joan Zeltinger

    IPC分类号： C12N5/00

    CPC分类号： A61L27/3886 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/507

    摘要： The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.

    摘要翻译： 本发明涉及促进组织器官中血管形成的方法。 特别地，该方法涉及植入或附着工程化的三维基质组织以促进心脏和相关组织中的内皮细胞化和血管发生。 本发明的三维基质组织可用于多种应用，包括但不限于促进损伤的心肌的修复和再生，促进心脏手术期间的血管化和愈合，促进吻合部位的血管形成 并促进损伤的骨骼肌，平滑肌或结缔组织的血管化和修复。

    SIDE-CHAIN CRYSTALLIZABLE POLYMERS FOR MEDICAL APPLICATIONS
    4.
    发明申请
    SIDE-CHAIN CRYSTALLIZABLE POLYMERS FOR MEDICAL APPLICATIONS 有权
    用于医疗应用的侧链可结晶聚合物

    公开(公告)号：US20110213456A1

    公开(公告)日：2011-09-01

    申请号：US13101391

    申请日：2011-05-05

    申请人： Donald K. Brandom ,  James E. McGrath ,  Joan Zeltinger ,  Eric V. Schmid ,  Robert K. Schultz

    发明人： Donald K. Brandom ,  James E. McGrath ,  Joan Zeltinger ,  Eric V. Schmid ,  Robert K. Schultz

    IPC分类号： A61F2/82 ,  C08F220/18 ,  C08F8/14

    CPC分类号： A61L31/18 ,  A61F2/92 ,  A61K49/12 ,  A61K49/126 ,  A61K49/128 ,  A61L31/06 ,  C08F220/00 ,  C08G63/00 ,  C08G63/08

    摘要： Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.

    摘要翻译： 侧链可结晶（SCC）聚合物可用于各种医疗应用。 在某些应用中，含重链原子的侧链可结晶聚合物（HACSCCP）特别有用。 HACSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物。 在某些构型中，重质原子以有效使聚合物不透射线的量存在。 包括HACSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。 包括SCC聚合物的聚合物材料也可制成其他医疗装置，例如支架。

    Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
    6.
    发明授权
    Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments 失效
    组织，合成或机械心脏瓣膜或瓣膜段的消毒，播种，培养，储存，运输和测试的装置和方法

    公开(公告)号：US5846828A

    公开(公告)日：1998-12-08

    申请号：US478309

    申请日：1995-06-07

    申请人： Alvin Peterson ,  Lee K. Landeen ,  John Bennett ,  Jason Gee ,  Scott Chesla ,  Joan Zeltinger

    发明人： Alvin Peterson ,  Lee K. Landeen ,  John Bennett ,  Jason Gee ,  Scott Chesla ,  Joan Zeltinger

    IPC分类号： C12M3/00 ,  A01N1/02 ,  A61F2/06 ,  A61F2/24 ,  C12N5/00

    CPC分类号： C12M29/12 ,  A61F2/062 ,  A61F2/2415 ,  Y10S623/922

    摘要： An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing heart valves is disclosed. Specifically, the present invention relates to an apparatus and method for dynamically seeding and culturing heart valves with human cells, resulting in a heart valve populated with viable human cells. In a preferred embodiment, the apparatus includes a fluid reservoir, a pneumatic pressure chamber, a pressure source for providing a varying pressure to the pressure chamber, and a heart valve holder. In an alternative exemplary embodiment, the apparatus includes a fluid reservoir, a pump, a venturi tube, a heart valve chamber, a heart valve holder, and a valve connected to a timer. In each embodiment, the components are combined in a fluid circuit to create a variable cycling and pulsatile fluid flow for seeding and culturing which can closely resemble the physiological conditions found in the human heart.

    摘要翻译： 公开了一种用于灭菌，播种，培养，储存，运输和测试心脏瓣膜的装置和方法。 具体而言，本发明涉及用人体细胞动态播种和培养心脏瓣膜的装置和方法，导致心脏瓣膜内含有活细胞。 在优选实施例中，该装置包括流体储存器，气动压力室，用于向压力室提供变化的压力的压力源和心脏瓣膜保持器。 在替代的示例性实施例中，该装置包括流体储存器，泵，文氏管，心脏瓣膜腔，心脏瓣膜保持器和连接到计时器的阀。 在每个实施例中，组件被组合在流体回路中以产生用于播种和培养的可变循环和脉动流体流，其可以非常类似于在人心脏中发现的生理条件。

    Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
    7.
    发明授权
    Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts 失效
    用于消毒，播种，培养，储存，运送和测试组织，合成或天然血管移植物的装置和方法

    公开(公告)号：US5792603A

    公开(公告)日：1998-08-11

    申请号：US672697

    申请日：1996-06-27

    申请人： Noushin Dunkelman ,  Alvin E. Peterson ,  Lee Kevin Landeen ,  Joan Zeltinger

    发明人： Noushin Dunkelman ,  Alvin E. Peterson ,  Lee Kevin Landeen ,  Joan Zeltinger

    IPC分类号： C12M3/00 ,  A61F2/06 ,  A61L2/24 ,  A61L27/50 ,  C12N5/06 ,  C12N5/08

    CPC分类号： A61L2/24 ,  A61F2/062 ,  A61L27/507 ,  C12M21/08 ,  C12M23/46 ,  C12M25/14 ,  C12M29/10 ,  C12M35/04 ,  C12M41/00 ,  Y10S623/912

    摘要： An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing vascular grafts is disclosed. Specifically, the present invention relates to an apparatus and method for seeding and culturing vascular grafts with human cells. The apparatus includes a fluid reservoir, a pump, an alternating pressure source, and at least one treatment chamber. By alternating pressure to a support structure within the treatment chamber upon which a vascular graft scaffold is positioned, a varying radial stress is placed on the scaffold. In an alternative embodiment, fluid is pumped directly through the vascular graft subjecting the vascular graft to radial and shear stresses. Applying shear and/or radial stresses to the vascular graft during seeding and culturing simulates physiological conditions.

    摘要翻译： 公开了一种消毒，播种，培养，储存，运输和测试血管移植物的装置和方法。 具体地说，本发明涉及一种用人细胞种植和培养血管移植物的装置和方法。 该装置包括流体储存器，泵，交流压力源和至少一个处理室。 通过交替压力到位于血管移植支架的治疗室内的支撑结构，将变化的径向应力放置在支架上。 在替代实施例中，流体被直接泵送通过血管移植物使血管移植物受到径向和剪切应力。 在播种和培养期间对血管移植物施加剪切和/或径向应力模拟生理条件。