Patent search ap:("FORMA Therapeutics Page Inc.") AND inv:"Jennifer R. Thomason"

31.

发明授权
3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10442776B2

公开(公告)日：2019-10-15

申请号：US16219592

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair , David S. Millan , Matthew W. Martin

IPC: A61K31/553 , C07D498/04 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10 , C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

32.

发明授权
3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10377726B2

公开(公告)日：2019-08-13

申请号：US16173871

申请日：2018-10-29

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , David S. Millan , Matthew W. Martin

IPC: A61K31/553 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10 , C07D267/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

33.

发明申请
3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开

公开(公告)号：US20190119233A1

公开(公告)日：2019-04-25

申请号：US16220046

申请日：2018-12-14

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , David S. Millan , Matthew W. Martin

IPC: C07D267/14 , C07D413/04 , C07D267/12 , C07D413/06 , C07D401/06 , C07D417/04 , C07D471/04 , C07D498/04 , C07D243/14 , C07D291/08 , C07D498/08 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D495/10 , C07D491/107 , C07D413/08 , C07D493/08 , C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

34.

发明申请
3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开

公开(公告)号：US20190119227A1

公开(公告)日：2019-04-25

申请号：US16219381

申请日：2018-12-13

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, JR. , Kenneth W. Bair , David S. Millan , Matthew W. Martin

IPC: C07D267/14 , C07D413/04 , C07D267/12 , C07D413/06 , C07D401/06 , C07D417/04 , C07D471/04 , C07D498/04 , C07D243/14 , C07D291/08 , C07D498/08 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D495/10 , C07D491/107 , C07D413/08 , C07D493/08 , C07D413/12

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

35.

发明申请
METHODS USING HDAC11 INHIBITORS 审中-公开

公开(公告)号：US20190084945A1

公开(公告)日：2019-03-21

申请号：US16202207

申请日：2018-11-28

Applicant: FORMA Therapeutics, Inc.

Inventor： Jennifer Lee , Nicholas Barczak , Jaime A. Escobedo , Chiara Conti , Bingsong Han , David R. Lancia, JR. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Xiaozhang Zheng

IPC: C07D263/58 , C07D401/04 , C07C53/06 , C07D235/30 , C07D221/20 , C07D209/54 , C07D209/40 , A61K45/06 , A61K31/5383 , A61K31/5377 , A61K31/52 , A61K31/506 , A61K31/4985 , A61K31/4709 , A61K31/4439 , A61K31/438 , A61K31/437 , A61K31/435 , A61K31/428 , C07D498/04 , C07D491/107 , C07D491/056 , C07D487/04 , C07D473/00 , C07D417/06 , C07D413/14 , C07D413/12 , C07D413/06 , C07D405/04 , C07D403/06 , C07D403/04 , C07D401/14 , C07D401/06 , A61K31/427 , A61K31/4245 , A61K31/423 , A61K31/422 , A61K31/4192 , A61K31/4188 , A61K31/4184 , A61K31/4178 , A61K31/404 , A61K31/403 , A61P35/00 , C07D277/82

CPC classification number: C07D263/58 , A61K31/403 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/5383 , A61K45/06 , A61P35/00 , C07C53/06 , C07D209/40 , C07D209/54 , C07D221/20 , C07D235/30 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D473/00 , C07D487/04 , C07D491/056 , C07D491/107 , C07D498/04

Abstract: The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

36.

发明申请
[6,6] FUSED BICYCLIC HDAC8 INHIBITORS 审中-公开

公开(公告)号：US20180354919A1

公开(公告)日：2018-12-13

申请号：US16003861

申请日：2018-06-08

Applicant: FORMA Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Jennifer R. Thomason , Mary-Margaret Zablocki , Bingsong Han , Nicholas Barczak , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , Kenneth W. Bair

IPC: C07D265/36 , C07D265/34 , C07D487/04 , C07D513/04 , C07D417/06 , C07D471/04 , C07D413/10 , C07D279/14 , C07D279/16 , C07D401/04 , C07D413/06 , C07D413/12 , C07D491/107

CPC classification number: C07D265/36 , C07D265/34 , C07D279/14 , C07D279/16 , C07D401/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D491/107 , C07D513/04

Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

37.

发明申请
3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS 审中-公开
Title translation: 3-ALKYL BICYCLIC [4,5,0]氢氧化物作为HDAC抑制剂

公开(公告)号：US20160221972A1

公开(公告)日：2016-08-04

申请号：US15013820

申请日：2016-02-02

Applicant: Forma Therapeutics, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David Lancia, JR. , David S. Millan , Matthew W. Martin , Kenneth W. Bair

IPC: C07D267/14 , C07D417/04 , C07D413/14 , C07D413/06 , C07D413/12 , C07D498/08 , C07D498/04 , C07D243/14 , C07D403/06 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/10 , C07D471/04 , C07D405/06 , C07D413/04

CPC classification number: C07D267/14 , C07D243/14 , C07D267/12 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/04 , C07D413/06 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/107 , C07D493/08 , C07D495/10 , C07D498/04 , C07D498/08

Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

Abstract translation: 本公开涉及可用于治疗与HDAC相关的疾病或病症的锌依赖性组蛋白脱乙酰酶（HDAC）的抑制剂，例如具有式I的HDAC6：其中R，L，X 1，X 2，X 3，X 4， Y1，Y2，Y3和Y4。