Abstract:
The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R1, R2Y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Abstract:
The invention provides a data filtering system and method, wherein the data filtering system comprises: an extracting unit for extracting property characteristic of source data and sending it to a selecting unit; the selecting unit for selecting at least one property characteristic based on which data filtering is performed and for sending the selected property characteristic to a filtering condition generating unit; the filtering condition generating unit which, according to the selected at least one property characteristic, generates at least one filtering module that corresponds to the at least one property characteristic respectively and combines the at least one filtering module to generate filtering conditions; a data filter analysis unit which performs the filtering on source data according to the filtering conditions to thereby generate target data. With the invention, it is ensured that when characteristic of data changes, filtering modules can be recombined freely so as to adapt to the change of data characteristic efficiently.
Abstract:
The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
Abstract:
Sensor-based authentication technique embodiments are presented which generally employ sensor readings captured by a user's computing device (such as a mobile computing device like a cell phone, smart phone, PDA, and so on) to authenticate the user's access to a computer network-based service (such as a web-service) that is secured with traditional textual passwords. These traditional passwords are saved in an off-device password repository service. The aforementioned sensor readings are not cached on the user's computing device and are immediately streamed to the password repository service, where they are validated against a pre-arranged, known sensor-based password. If the validation succeeds, access to the password protected service is brokered by the password repository service on behalf of the user using the appropriate traditional password, and the user's computing device is granted access.
Abstract:
A computer-implemented technique includes receiving a first input from a user at a user device, the first input including a first word of a first alphabet-based language, which is a transliteration of a non-alphabet-based language, which is one of a logogram-based language and a syllabogram-based language. The technique then compares the first words to pluralities of potential translated words from one or more datastores associated with a second alphabet-based language and the logogram-based or syllabogram-based languages. The technique may then generate a probability score for each of the pluralities of potential translated words, the probability score indicating a likelihood of an appropriate translation. The techniques may then provide the user with some or all of the pluralities of potential translated words and the user may select an appropriate translated word to obtain a selected word, which may then be displayed via a display of the user device.
Abstract:
A scan clock modifier, a method of providing a variable scan clock, an IC including a scan clock modifier and a library including a cell of a scan clock modifier. In one embodiment, the scan clock modifier includes: (1) logic circuitry configured to provide at least one selected clock signal based on a test scan clock signal and a first clock control signal, both of the test scan clock signal and the first clock control signal received from test equipment and (2) comparison logic configured to provide a scan clock signal based on the at least one selected clock signal and at least one other clock control signal received from the test equipment, wherein the first and the at least one other clock control signals are different clock control signals.
Abstract:
An equivalent radio frequency (RF) notch filter, an RF chip, and a receiver are provided. The equivalent RF notch filter includes: a local oscillation (LO) circuit, configured to provide a LO frequency signal; configured to be connected in parallel with the main chain, and down-convert signals of the main chain; and a frequency selective circuit realized by impedance difference, configured to provide different impedances for down-converted signals with different frequencies from the mixing circuit, so as to absorb the signals that need to be suppressed.
Abstract:
This disclosure provides substrate stacks for use in photovoltaic cells and methods of manufacturing the same. In one aspect, a substrate stack can include a substrate layer having at least one surface with an RMS roughness value that is greater than 9 nm. The substrate stack can also include a transparent conductive oxide layer disposed over the substrate layer. The transparent conductive oxide layer can include at least a first surface with an RMS roughness value that is greater than 9 nm and a second surface with an RMS roughness value that is greater than 9 nm. The RMS roughness value of the second surface can be greater than the RMS value of the first surface.
Abstract:
In a described implementation, a channel cost metric (CCM) is determined in a wireless network environment. The CCM may be determined responsive to an expected transmission time (ETT) and a frequency of air time (FAT), which reflects a channel utilization. In an example implementation, a channel assignment and/or a routing for a network configuration may be switched responsive to the determined CCM.
Abstract:
Subject matter disclosed herein relates to data management of multiple applications, and in particular, to fault tolerance for such management.