摘要:
Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要:
The system controls the frequency of an ultrasonic signal to be applied to a waveguide, such that the frequency corresponds to a preferred resonance mode of the waveguide and not to adjacent undesirable resonance modes. The system operates by carrying out a first scan of a predetermined portion of the generated signal, determining the number of resonance modes of the waveguide within this portion and selecting from these resonance modes either that one mode which is at a central frequency or that one mode which is at a frequency nearest thereto. The system may also set limits on each side of the selected resonance mode and carry out a second scan within these limits each time that the generator is activated to check whether the selected resonance mode is drifting.
摘要:
A filtration plate includes an upper plate having one or more wells formed therein, a lower plate having one or more wells corresponding to the wells of the upper plate, a filter media separating the upper plate wells from the lower plate wells, and a seal formed at an interface between the upper plate and the lower plate. A method of assembling the filtration plate comprises applying a seal-promoting material to a component of the filtration plate and curing the seal-promoting material to form the seal at an interface between the upper plate and the lower plate.
摘要:
In various embodiments, a system for controlling radiotherapy equipment in a treatment environment includes a controller for receiving, from one or more image capture devices, data indicating the position of one or more objects in the treatment environment. Based on the position data, the controller defines one or more exclusionary zones from which the radiotherapy equipment is excluded. Each zone has a buffer area surrounding one or more of the objects. The controller further directs the radiotherapy equipment such that a radiotherapy treatment plan is delivered without the equipment entering into the exclusionary zones.
摘要:
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
摘要:
This invention relates to a portable and effective device for exercising extremities of individuals who have suffered from debility. The device is comprised of a rectangular base with a similar rectangular extremity support surface attached to said base. The support surface is attached to said base by mechanical glide hardware. The mechanical glide hardware is comprised such that an individual can place their affected extremity on the support surface and move their extremity with minimal or trace muscle power through a linear, rotating, or arc range of motion.
摘要:
The apparatus comprises an ultrasonic vibration generator (1) and a lens (2) affixed thereto adapted to focus the ultrasonic vibration at a predetermined zone. It may be used to destroy certain types of cancerous cell which lie close beneath the surface, such as skin cancers and other melanomas. Other cosmetic skin treatments may also be carried out, such as restructuring collagen molecules in order to tighten and restructure skin tissue, depilation and to destroy dyed tissue and thereby aid removal of unwanted tattoos.