公开(公告)号：US20090020985A1

公开(公告)日：2009-01-22

申请号：US12216922

申请日：2008-07-11

Applicant: Frank Sauer

Inventor： Frank Sauer

IPC: B60R21/20

CPC classification number: B60R21/217 ,  B60R21/203

Abstract: An airbag fastening system in an airbag module has a clamping connection and includes a retaining ring for an injection orifice of the airbag in an airbag receptacle surrounding both the airbag module and the retaining ring. The retaining ring has a reducing width on an outer face in a main pulling direction when the airbag unfolds. At least a portion of the airbag receptacle or a component associated with the airbag receptacle has a smaller width above the retaining ring than a greatest width of the retaining ring. A lower end of the airbag forms the injection orifice, is folded over the retaining ring, and extends between the retaining ring and the airbag receptacle or the component. The retaining ring includes at least one portion having a conically tapered cross-section on the outer face in the main pulling direction when the airbag unfolds.

Abstract translation: 安全气囊模块中的气囊紧固系统具有夹紧连接，并且包括用于安全气囊插入件中的用于安全气囊的注射孔的保持环，围绕安全气囊模块和保持环。 当气囊展开时，保持环在主拉动方向上具有在外表面上的减小宽度。 安全气囊插座的至少一部分或与安全气囊插座相关联的部件在保持环之上具有比保持环的最大宽度更小的宽度。 气囊的下端形成喷射孔，折叠在保持环上，并且在保持环和气囊插座或部件之间延伸。 当气囊展开时，保持环包括在主拉动方向上的外表面上具有锥形锥形横截面的至少一个部分。

公开(公告)号：US20090014987A1

公开(公告)日：2009-01-15

申请号：US12230845

申请日：2008-09-05

Applicant: Steffen Weigand ,  Frank Sauer ,  Stefan Hamels ,  Ralf Glaab

Inventor： Steffen Weigand ,  Frank Sauer ,  Stefan Hamels ,  Ralf Glaab

IPC: B60R21/20

CPC classification number: B60R21/2035 ,  B60R21/217

Abstract: An airbag module including a gas generator with at least one laterally projecting fastening portion; a generator support; an airbag with an inflation opening; a cover cap; and latching elements for connecting the generator support to the cover cap. The airbag has a plate proximate to the inflation opening, the plate including an opening for the gas generator. Latching elements are provided to hold the plate and the airbag connected thereto, and to hold the fastening portion of the gas generator situated between the generator support and the plate. The plate, at least in the region of these latching elements, is larger than the external dimensioning of the folded airbag in the region of the inflation opening.

Abstract translation: 一种安全气囊模块，包括具有至少一个横向突出的紧固部分的气体发生器; 发电机支架; 具有充气开口的气囊; 盖帽; 以及用于将发电机支撑件连接到盖帽的闭锁元件。 气囊具有靠近充气开口的板，该板包括用于气体发生器的开口。 提供锁定元件以保持连接到其上的板和气囊，并且保持位于发电机支撑件和板之间的气体发生器的紧固部分。 至少在这些闩锁元件的区域中，该板大于在充气开口区域中折叠的气囊的外部尺寸。

公开(公告)号：US20080233101A1

公开(公告)日：2008-09-25

申请号：US11520494

申请日：2006-09-12

Applicant: Frank Sauer

Inventor： Frank Sauer

IPC: A61K38/47 ,  C12N5/06 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12N15/63

Abstract: The invention provides a method of regulating transcription of a gene that is a target for an epigenetic regulator; a method of characterizing the transcriptional activity of such a gene; a method of screening for a chromosomal element (CE) for an epigenetic regulator of a target gene; an isolated complex including an epigenetic regulator for a target gene, wherein the epigenetic regulator is specifically bound to a non-coding polynucleotide; and a method of screening for a modulator of transcription of a gene that is a target for an epigenetic regulator.

Abstract translation: 本发明提供了调节作为表观遗传调节物靶标的基因的转录的方法。 表征该基因的转录活性的方法; 筛选靶基因的表观遗传调节剂的染色体元件（CE）的方法; 包括靶基因的表观遗传调节剂的分离的复合物，其中所述表观遗传调节子特异性结合于非编码多核苷酸; 以及筛选作为表观遗传调节物的靶基因的转录调节物的方法。

公开(公告)号：US20080095421A1

公开(公告)日：2008-04-24

申请号：US11874266

申请日：2007-10-18

Applicant: Yiyong Sun ,  Rui Liao ,  Chenyang Xu ,  Frank Sauer

Inventor： Yiyong Sun ,  Rui Liao ,  Chenyang Xu ,  Frank Sauer

IPC: A61B5/00

CPC classification number: A61B6/487 ,  A61B5/06 ,  A61B5/062 ,  A61B6/12 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5247 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4254 ,  A61B8/4416

Abstract: A fluoroscopy image is registered with data representing a volume, identifying a catheter position relative to a volume represented by preoperative volume data. The catheter position relative to a patient volume represented by data acquired without scanning the catheter is displayed. For example, a 2D fluoroscopy image is registered with respect to coordinates of a 3D preoperative CT or MRI volume by registering the fluoroscopy image and the preoperative volume to 3D ultrasound coordinates.

Abstract translation: 用表示体积的数据记录荧光透视图像，识别相对于由术前体积数据表示的体积的导管位置。 显示相对于由不扫描导管获取的数据表示的患者体积的导管位置。 例如，通过将荧光透视图像和术前体积登记到3D超声坐标，相对于3D术前CT或MRI体积的坐标登记2D透视图像。

公开(公告)号：US20080007037A1

公开(公告)日：2008-01-10

申请号：US11812987

申请日：2007-06-22

Applicant: Frank Sauer

Inventor： Frank Sauer

IPC: B60R21/231 ,  B60R21/26

CPC classification number: B60R21/217 ,  B60R21/205 ,  B60R21/206

Abstract: An airbag module including a gas generator and an airbag. The gas generator and the airbag are arranged in the module housing one behind the other in the direction of a longitudinal axis of the airbag module so that the dimension of the airbag module is greater in the direction of the longitudinal axis than the dimension of the airbag module in a direction transversely to the longitudinal axis. The module housing is divided in the direction of the longitudinal axis of the airbag module and includes two housing shells. The airbag is connected to the module housing by a clamping frame which includes at least one gas conduction element.

Abstract translation: 一种气囊组件，包括气体发生器和气囊。 气体发生器和气囊沿着安全气囊模块的纵向轴线的方向一个接一个地布置在模块壳体中，使得气囊模块的尺寸在纵轴方向上大于气囊的尺寸 在横向于纵向轴线的方向上模块化。 模块壳体沿着安全气囊模块的纵向轴线的方向分开并且包括两个壳体壳体。 气囊通过包括至少一个气体传导元件的夹紧框架连接到模块壳体。

公开(公告)号：US20070287902A1

公开(公告)日：2007-12-13

申请号：US10569957

申请日：2004-08-24

Applicant: Kristine Fuimaono ,  Gal Hayam ,  Yuval Karmi ,  Reinmar Killmann ,  Assaf Preiss ,  Norbert Rahn ,  Frank Sauer ,  Chenyang Xu

Inventor： Kristine Fuimaono ,  Gal Hayam ,  Yuval Karmi ,  Reinmar Killmann ,  Assaf Preiss ,  Norbert Rahn ,  Frank Sauer ,  Chenyang Xu

IPC: A61B18/14

CPC classification number: A61B6/032 ,  A61B5/055 ,  A61B5/7285 ,  A61B6/541 ,  A61B8/14 ,  A61B8/543 ,  A61B18/1492 ,  A61B2018/00375 ,  A61B2018/00839 ,  G01R33/5608

Abstract: The invention relates to a device and to a method for visual assistance during the electrophysiological use of a catheter in the heart, enabling electroanatomic 3D mapping data relating to an area of the heart to be treated to be visualised during the use of the catheter. Before the catheter is used, 3D image data of a body region containing the area to be treated is detected by means of a method for tomographic 3D imaging. The area to be treated or significant parts thereof are extracted from said 3D image data, in order to obtain selected 3D image data. The electroanatomic 3D mapping data and the selected 3D image data obtained are then classed in terms of position and dimension, and are adjacently visualised, for example, during the catheter ablation. The inventive method and associated device enable the orientation of the operator to be improved during the use of a catheter in the heart.

Abstract translation: 本发明涉及一种用于在心脏中电生理使用导管期间的视觉辅助的装置和方法，使得在使用导管期间能够使待处理的心脏区域的电解剖3D图映射数据被可视化。 在使用导管之前，通过用于断层3D成像的方法来检测包含待处理区域的身体区域的3D图像数据。 从所述3D图像数据中提取要处理的区域或其重要部分，以便获得所选择的3D图像数据。 然后根据位置和尺寸对所获得的电解剖3D图像数据和所选择的3D图像数据进行分类，并且例如在导管消融期间相邻地可视化。 本发明的方法和相关装置使得在使用心脏中的导管时能够改善操作者的取向。

公开(公告)号：US20070230764A1

公开(公告)日：2007-10-04

申请号：US10951167

申请日：2004-09-27

Applicant: Ali Khamene ,  Frank Sauer

Inventor： Ali Khamene ,  Frank Sauer

IPC: G06K9/00

CPC classification number: G06T15/08 ,  G06T2210/41

Abstract: A system and corresponding method for fast generation of digitally reconstructed radiograph (DRR) images are provided, the system including a processor, an imaging adapter in signal communication with the processor for receiving volumetric data, a preprocessing unit in signal communication with the processor for preprocessing subvolumes into a set of local line integrals, and an online processing unit in signal communication with the processor for online processing global line integrals, each from a set of local line integrals, respectively; and the corresponding method including receiving three-dimensional volumetric data, subdividing the volumetric data into a set of overlapping subvolumes, preprocessing each subvolume into a dense set of local line integrals at several angles and positions, online processing global line integrals, each from a set of local line integrals, respectively, and adding up values of the set of local line integrals for each global line integral to form pixels of the DRR image.

Abstract translation: 提供了用于快速生成数字重建X射线照片（DRR）图像的系统和相应方法，该系统包括处理器，与处理器进行信号通信的成像适配器，用于接收体积数据，与处理器进行信号通信的预处理单元，用于预处理 子体积成一组局部线积分，以及与处理器进行信号通信的在线处理单元，用于在线处理全局线积分，分别来自一组局部线积分; 以及相应的方法，包括接收三维体积数据，将体数据细分为一组重叠的子体积，将每个子体积在几个角度和位置处预处理成一组密集的局部线积分，在线处理全局线积分，每一个集合 的本地线积分，并且将每个全局线积分的局部线积分的集合的值相加以形成DRR图像的像素。

公开(公告)号：US20060188139A1

公开(公告)日：2006-08-24

申请号：US11303564

申请日：2005-12-16

Applicant: Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James Williams

Inventor： Ali Khamene ,  Charles Florin ,  Frank Sauer ,  James Williams

IPC: G06K9/00

CPC classification number: G06K9/00208 ,  G06K2009/00932 ,  G06K2209/05

Abstract: A system and method for tree structure based two-dimensional to three-dimensional registration are provided for receiving three-dimensional (3D) data indicative of vessels, segmenting the 3D data with a vessel tree, simulating two-dimensional (2D) data responsive to the segmented 3D data to form a simulated 2D image, receiving 2D data indicative of vessels, segmenting the received 2D data with a vessel tree, finding a distance transform of the segmented 2D data to form a 2D distance map image, considering a set of poses as state vectors with the corresponding probability computed using the similarity measure computation, re-sampling the pose vector to find a set of most probable poses and considering them as hypothesized poses, recomputing the projection and re-evaluating the probability of the hypothesized poses and updating the state vector until the optimal pose is found.

Abstract translation: 提供了一种用于基于树结构的二维至三维配准的系统和方法，用于接收指示血管的三维（3D）数据，用血管树分割3D数据，模拟二维（2D）数据，响应于 分割的3D数据以形成模拟2D图像，接收指示血管的2D数据，用血管树分割接收的2D数据，找到分割的2D数据的距离变换以形成2D距离图图像，考虑一组姿势 作为具有使用相似度测量计算计算的相应概率的状态向量，重新采样姿态向量以找到一组最可能的姿势并将其视为假设姿势，重新计算投影并重新估计假设姿势的概率和更新 状态矢量，直到找到最佳姿势。

公开(公告)号：US20060159323A1

公开(公告)日：2006-07-20

申请号：US11330633

申请日：2006-01-12

Applicant: Yiyong Sun ,  Fred Azar ,  Chenyang Xu ,  Frank Sauer ,  Norbert Rahn

Inventor： Yiyong Sun ,  Fred Azar ,  Chenyang Xu ,  Frank Sauer ,  Norbert Rahn

IPC: G06K9/00 ,  G06K9/32

CPC classification number: A61B5/0035 ,  A61B5/042 ,  A61B5/055 ,  A61B6/03 ,  G06T7/33 ,  G06T2207/30048

Abstract: A system and method for automatically registering a three dimensional (3D) pre-operative image of an anatomical structure with intra-operative electrophysiological (EP) points of a 3D electro-anatomical (EA) image map of the anatomical structure is disclosed. The pre-operative image is displayed in a first supporting view. The intra-operative EA image map is displayed in a second supporting view. An alignment of the pre-operative image with the intra-operative map is performed by identifying at least one corresponding point on each image. The view of the pre-operative image is integrated with the EA map based on the alignment.

Abstract translation: 公开了一种用于自动登记解剖结构的三维（3D）术前图像的解剖结构的3D电解剖（EA）图像的手术电生理（EP）点的系统和方法。 术前图像显示在第一支持视图中。 术中EA图像映射显示在第二支持视图中。 通过识别每个图像上的至少一个对应点来执行术前图像与手术前图像的对准。 基于对齐，将术前图像的视图与EA图集成。

公开(公告)号：US07079132B2

公开(公告)日：2006-07-18

申请号：US10222182

申请日：2002-08-16

Applicant: Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

Inventor： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

IPC: G06T15/00

CPC classification number: A61B8/467 ,  A61B8/00 ,  A61B8/462 ,  A61B8/466 ,  A61B8/483 ,  A61B8/5238 ,  G01S7/52034 ,  G01S7/52036 ,  G01S7/52068 ,  G01S7/52084 ,  G01S15/8993

Abstract: A method for local 3-dimensional (3D) reconstruction from 2-dimensional (2D) ultrasound images includes deriving a 2D image of an object; defining a target region within said 2D image; defining a volume scan period; during the volume scan period, deriving further 2D images of the target region and storing respective pose information for the further 2D images; and reconstructing a 3D image representation for the target region by utilizing the 2D images and the respective pose information.