公开(公告)号：US11845723B2

公开(公告)日：2023-12-19

申请号：US17127297

申请日：2020-12-18

Applicant: GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

Inventor： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/704 ,  A61K31/7068 ,  C07D519/00 ,  A61K31/554 ,  A61K31/695 ,  A61K31/395 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07F7/18

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/538 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5545 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20200345699A1

公开(公告)日：2020-11-05

申请号：US16849747

申请日：2020-04-15

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  John O. Link ,  Jie Xu

IPC: A61K31/4196 ,  A61K45/06 ,  C07D403/10 ,  C07D403/14 ,  A61P31/18 ,  A61K31/7076 ,  A61K31/537 ,  A61K31/52 ,  A61K31/675

Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.

公开(公告)号：US20200017471A1

公开(公告)日：2020-01-16

申请号：US16510647

申请日：2019-07-12

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Devan Naduthambi ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/14 ,  C07D471/08 ,  A61K39/395 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/444 ,  A61K31/497

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20190270727A1

公开(公告)日：2019-09-05

申请号：US16274106

申请日：2019-02-12

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P35/02 ,  A61P31/20 ,  C07D519/00 ,  A61K31/496

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20180305315A1

公开(公告)日：2018-10-25

申请号：US15957739

申请日：2018-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Todd Appleby ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Juan A. Guerrero ,  Salman Y. Jabri ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Gregory Notte ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Chandrasekar Venkataramani ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D213/69 ,  A61K45/06 ,  A61K31/444 ,  C07D401/14 ,  A61K31/4545 ,  C07D213/85 ,  A61K31/44 ,  C07D213/30 ,  C07D295/088 ,  A61K31/5377

CPC classification number: C07D213/69 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D295/088 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00

Abstract: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.