公开(公告)号：US5749882A

公开(公告)日：1998-05-12

申请号：US544860

申请日：1995-10-18

申请人： Charles C. Hart ,  Eduardo Chi Sing ,  Mark P. Ashby

发明人： Charles C. Hart ,  Eduardo Chi Sing ,  Mark P. Ashby

IPC分类号： A61B17/22 ,  A61B17/32

CPC分类号： A61B17/32075 ,  A61B2017/22097

摘要： A valvulotome for disrupting valve cusps in the vein of a patient includes a shaft and a cutting member which extends along an axis that defines an axial direction as well as an angular direction. First and second portions of the cutting member define respective cutting edges which extend outwardly of the axis in an angular relationship and an axial relationship with each other. The first and second cutting edges engage and disrupt different cusps of the valve when the shaft is withdrawn axially from the vein. Each of the cutting edges is protected by a proximate shoulder which inhibits the engagement of sidebranches by the associated cutting edge. The cutting member may be formed as a helical blade, a wire or a cylinder and may be provided with a swivel coupling as well as a sheath operable to cover or expose the cutting member.

摘要翻译： 用于扰乱患者静脉中的瓣膜尖瓣的瓣膜切开机包括轴和切割构件，其沿着限定轴向方向和角度方向的轴线延伸。 切割构件的第一和第二部分限定相对于彼此以角度关系和轴向关系轴线向外延伸的相应切割边缘。 当轴从静脉轴向撤出时，第一和第二切削刃接合并破坏阀的不同尖端。 每个切割边缘被靠近的肩部保护，该肩部阻止侧分支通过相关联的切割边缘的接合。 切割构件可以形成为螺旋叶片，线或圆柱体，并且可以设置有旋转接头以及可操作以覆盖或暴露切割构件的护套。

公开(公告)号：US09713437B2

公开(公告)日：2017-07-25

申请号：US14165253

申请日：2014-01-27

申请人： Larry W. Fullerton ,  John E. Greene ,  Tommy G. Nguyen ,  Eduardo Chi Sing

发明人： Larry W. Fullerton ,  John E. Greene ,  Tommy G. Nguyen ,  Eduardo Chi Sing

IPC分类号： A61B5/06 ,  A61B90/98 ,  A61B5/00 ,  A61B5/05 ,  A61B34/20 ,  A61B90/00

CPC分类号： A61B5/064 ,  A61B5/0507 ,  A61B5/4312 ,  A61B5/6847 ,  A61B90/39 ,  A61B2034/2048 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61B2090/3975 ,  A61B2090/3987 ,  A61B2090/3991

摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient's skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.

公开(公告)号：US09386942B2

公开(公告)日：2016-07-12

申请号：US13053197

申请日：2011-03-21

申请人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  Luis Urquidi

发明人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  Luis Urquidi

IPC分类号： A61B6/12 ,  A61B5/06 ,  A61B5/05 ,  A61B5/00 ,  A61B8/08 ,  A61B19/00 ,  A61B17/00

CPC分类号： A61B90/39 ,  A61B5/0507 ,  A61B5/06 ,  A61B5/064 ,  A61B5/4312 ,  A61B8/0825 ,  A61B8/0841 ,  A61B8/481 ,  A61B10/0041 ,  A61B17/3468 ,  A61B90/37 ,  A61B2017/00438 ,  A61B2017/00442 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/397 ,  A61B2090/3975 ,  A61B2090/3983 ,  A61B2090/3987

摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.

摘要翻译： 提供了设备，系统和方法，用于定位患者身体内的损伤，例如在乳房内。 系统可以包括可植入在目标组织区域内或周围的一个或多个标记，以及用于发送和接收电磁信号以检测一个或多个标记的探针。 在使用期间，标记物进入目标组织区域，并将探针放置在患者皮肤上以检测和定位标记物。 然后至少部分地基于来自探针的定位信息从靶组织区域中移除包括病变和标记物的组织标本。

公开(公告)号：US20110014290A1

公开(公告)日：2011-01-20

申请号：US12887945

申请日：2010-09-22

申请人： Eduardo Chi Sing ,  Mark Ashby ,  Tin Tran ,  Richard Greff

发明人： Eduardo Chi Sing ,  Mark Ashby ,  Tin Tran ,  Richard Greff

IPC分类号： A61K38/48 ,  A61K38/16 ,  A61K9/10 ,  A61P7/04

CPC分类号： A61K9/122 ,  A61K9/0014 ,  A61K38/39 ,  A61K38/4833 ,  A61K2300/00

摘要： The present invention provides for a method and apparatus to provide hemostasis at a blood vessel puncture site, having a hemostasis material and a clot formation accelerator, wherein said clot formation accelerator is substantially dispersed throughout said hemostasis material.

摘要翻译： 本发明提供了一种在血管穿刺部位提供止血的方法和装置，其具有止血材料和凝块形成促进剂，其中所述凝块形成促进剂基本上分散在所述止血材料中。

公开(公告)号：US20100036414A1

公开(公告)日：2010-02-11

申请号：US12571929

申请日：2009-10-01

申请人： Andrew M. Cragg ,  Rodney Brenneman ,  Mark Ashby ,  Eduardo Chi Sing

发明人： Andrew M. Cragg ,  Rodney Brenneman ,  Mark Ashby ,  Eduardo Chi Sing

IPC分类号： A61B17/03

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00362 ,  A61B2017/00407 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00898 ,  A61F13/26 ,  A61F2013/00463

摘要： A system for facilitating hemostasis of a puncture site in a blood vessel injects an absorbable sponge pledget in a hydrated state to a position at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a tract dilator for locating the puncture, an introducer, and a pusher. The introducer includes a staging chamber for receiving the absorbent sponge pledget and a delivery chamber having a diameter smaller than a diameter of the staging chamber into which a hydrated pledget passes. The pledget is hydrated and compressed within the introducer and then ejected with the pusher to the delivery site to facilitate hemostasis of the blood vessel puncture. The system delivers the absorbable sponge pledget over a guidewire to ensure the proper positioning of the pledget over the puncture. The implanted absorbable sponge once delivered expands rapidly to fill the target site and is absorbed by the body over time.

摘要翻译： 用于促进血管中穿刺部位止血的系统将水合状态的可吸收海绵状物质注入到血管穿刺外部的位置，以促进止血。 该系统包括用于定位穿刺的管道扩张器，导引器和推动器。 引导器包括用于接收吸收性海绵质量分数的分级室和具有比水合物渗透到的分级室直径小的直径的输送室。 在导引器内水合并压缩毛细管，然后将推送器与推送器一起喷射到输送部位，以促进血管穿刺止血。 系统通过导丝将可吸收的海绵填充物传送到导线上，以确保穿刺物在穿刺上的正确定位。 植入的可吸收海绵一旦交付迅速扩张，填补目标部位，随着时间的推移被身体吸收。

公开(公告)号：US06183497B2

公开(公告)日：2001-02-06

申请号：US09335452

申请日：1999-06-17

申请人： Eduardo Chi Sing ,  Mark Ashby

发明人： Eduardo Chi Sing ,  Mark Ashby

IPC分类号： A61B1708

CPC分类号： A61M31/005 ,  A61B6/03 ,  A61B6/481 ,  A61B6/485 ,  A61B8/481 ,  A61B10/0233 ,  A61B17/0057 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2090/3933

摘要： An absorbable sponge containing a contrasting agent (e.g, radiopaque agent) that can be introduced to a biopsy tract or other puncture wound site is provided. The contrasting agent permits identification of the site by fluoroscopy or other imaging techniques.

摘要翻译： 提供了一种可吸收的海绵，其中含有可引入到活检管道或其他穿刺伤口部位的造影剂（例如不透射线剂）。 对比剂允许通过荧光透视或其他成像技术鉴定位点。

公开(公告)号：US5636644A

公开(公告)日：1997-06-10

申请号：US405697

申请日：1995-03-17

申请人： Charles C. Hart ,  Donald L. Gadberry ,  Eduardo Chi Sing

发明人： Charles C. Hart ,  Donald L. Gadberry ,  Eduardo Chi Sing

IPC分类号： A61B17/00 ,  A61B17/34 ,  A61B19/00 ,  A61M25/095

CPC分类号： A61B17/00234 ,  A61B17/3403 ,  A61B2090/306 ,  A61B2090/3937

摘要： A method for performing a surgical operation on a body conduit includes the step of inserting into the conduit an apparatus having at its distal end an element the location of which is detectable from regions exterior of the body. The apparatus is moved within the conduit until the element is positioned relative to a predetermined location where the element functions as a target. Detecting the location of this target within the conduit facilitates insertion of a surgical instrument percutaneously of the body and toward the predetermined location. The targeting apparatus may be used with an endoscope and may include a variety of active and passive elements which form the target. The surgical instrument can be inserted percutaneously transverse to the axis of the conduit to perform a variety of surgical operations. Sidebranch occlusion in an insitu procedure is greatly facilitated by this method and apparatus.

摘要翻译： 用于在体导管上执行外科手术的方法包括将具有其位置可从身体外部区域检测到的元件的装置插入导管中的装置。 该设备在管道内移动，直到元件相对于元件用作目标的预定位置定位。 在导管内检测该目标的位置有助于外科器械经皮体插入到预定位置。 靶向装置可以与内窥镜一起使用，并且可以包括形成靶的各种主动和被动元件。 手术器械可以经皮插入横向于导管的轴线，以执行各种手术操作。 通过这种方法和装置极大地促进了本体程序中的侧支阻塞。

公开(公告)号：US08475353B2

公开(公告)日：2013-07-02

申请号：US12543463

申请日：2009-08-18

申请人： Eduardo Chi Sing ,  Tommy G. Nguyen

发明人： Eduardo Chi Sing ,  Tommy G. Nguyen

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61N5/1016

摘要： An applicator for delivering brachytherapy includes elongate members movable between collapsed and expanded configurations for delivering brachytherapy within a lumpectomy cavity, a vaginal cavity, or other target region. The elongate members may be expandable into a symmetrical or asymmetrical expanded configuration, e.g., into a generally spherical, pear-shaped, or planar configuration. A system for delivering brachytherapy includes the applicator and an access device for lining and/or dilating a body cavity and/or for receiving the applicator therein. The access device is advanced into a body cavity, an expandable member on the access device is inflated, the applicator is advanced into the access device, and the elongate members are expanded to deliver radiation to the target region. Alternatively, the access device carries an expandable device into the target region, the expandable device is removed after dilating the target region, and the applicator is introduced through the access device to deliver radiation.

摘要翻译： 用于递送近距离放射治疗的施放器包括可在塌陷和膨胀构型之间移动的细长构件，用于在乳房切除腔，阴道腔或其它目标区域内输送近距离放射治疗。 细长构件可以可扩展成对称或不对称的膨胀构型，例如，变成大致球形的梨形或平面构型。 用于递送近距离放射治疗的系统包括施用器和用于衬里和/或扩张体腔和/或用于在其中接收施用器的进入装置。 进入装置前进到体腔中，进入装置上的可膨胀构件被充气，施加器前进到进入装置中，并且细长构件被扩张以将辐射传递到目标区域。 或者，接入设备将可扩展设备携带到目标区域中，在扩大目标区域之后移除可扩展设备，并且通过接入设备引入施加器以传送辐射。

公开(公告)号：US20110230700A1

公开(公告)日：2011-09-22

申请号：US12727209

申请日：2010-03-18

申请人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  Luis R. Urquidi

发明人： Eduardo Chi Sing ,  Tommy G. Nguyen ,  Luis R. Urquidi

IPC分类号： A61M36/12

CPC分类号： A61N5/1015 ,  A61M25/10 ,  A61M29/02 ,  A61N2005/1004

摘要： Brachytherapy treatment apparatus are provided that include an elongate body including a core member and an outer member surrounding and movable relative to the core member. One or more helical catheters are provided on a distal portion of the elongate body, e.g., including distal ends coupled to the core member and proximal ends coupled to the outer member. The outer member is movable relative to the core member, e.g., axially and/or rotationally, to direct the helical catheters between a collapsed configuration for introduction through a tissue tract to a target location, e.g., a lumpectomy cavity, and an expanded configuration. Each helical catheter includes a lumen, and, after expansion to the expanded configuration, a source of radiation may be introduced along the helical catheters and/or a lumen of the core member for delivering radiation to the target location. Optionally, the apparatus may include a balloon surrounding or within the helical members.

摘要翻译： 提供了近程放射疗法治疗装置，其包括细长体，其包括芯部件和围绕并可相对于芯部件移动的外部部件。 一个或多个螺旋导管设置在细长主体的远端部分上，例如包括联接到芯部件的远端和与外部部件相连的近端。 外部构件可相对于芯构件例如轴向和/或旋转地移动，以将螺旋形导管引导到折叠构型之间，用于通过组织管道引导到目标位置，例如乳房切除腔，以及扩张构型。 每个螺旋导管包括内腔，并且在膨胀到扩张构型之后，可以沿着螺旋形导管和/或芯构件的内腔引入辐射源，以将辐射传送到目标位置。 可选地，该装置可以包括围绕或在螺旋构件内的气球。

公开(公告)号：US07611479B2

公开(公告)日：2009-11-03

申请号：US10319260

申请日：2002-12-13

申请人： Andrew M. Cragg ,  Rodney Brenneman ,  Mark Ashby ,  Eduardo Chi Sing

发明人： Andrew M. Cragg ,  Rodney Brenneman ,  Mark Ashby ,  Eduardo Chi Sing

IPC分类号： A61F13/20

CPC分类号： A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00362 ,  A61B2017/00407 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00898 ,  A61F13/26 ,  A61F2013/00463

摘要： A system for facilitating hemostasis of a puncture site in a blood vessel injects an absorbable sponge pledget in a hydrated state to a position at an exterior of the blood vessel puncture to facilitate hemostasis. The system includes a tract dilator for locating the puncture, an introducer, and a pusher. The introducer includes a staging chamber for receiving the absorbent sponge pledget and a delivery chamber having a diameter smaller than a diameter of the staging chamber into which a hydrated pledget passes. The pledget is hydrated and compressed within the introducer and then ejected with the pusher to the delivery site to facilitate hemostasis of the blood vessel puncture. The system delivers the absorbable sponge pledget over a guidewire to ensure the proper positioning of the pledget over the puncture. The implanted absorbable sponge once delivered expands rapidly to fill the target site and is absorbed by the body over time.

摘要翻译： 用于促进血管中穿刺部位止血的系统将水合状态的可吸收海绵状物质注入到血管穿刺外部的位置，以促进止血。 该系统包括用于定位穿刺的管道扩张器，导引器和推动器。 引导器包括用于接收吸收性海绵质量分数的分级室和具有比水合物渗透到的分级室直径小的直径的输送室。 在导引器内水合并压缩毛细管，然后将推送器与推送器一起喷射到输送部位，以促进血管穿刺止血。 系统通过导丝将可吸收的海绵填充物传送到导线上，以确保穿刺物在穿刺上的正确定位。 植入的可吸收海绵一旦交付迅速膨胀，填补目标部位，随着时间的推移被身体吸收。