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    SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS
    31.
    发明申请
    SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS 有权
    用于控制和持续输送化合物的丝状颗粒

    公开(公告)号：US20130109762A1

    公开(公告)日：2013-05-02

    申请号：US13512789

    申请日：2010-11-30

    申请人： Andreas Lammel ,  Thomas Scheibel ,  Martin Schwab ,  Gerhard Winter ,  Markus Hofer ,  Julia Myschik

    发明人： Andreas Lammel ,  Thomas Scheibel ,  Martin Schwab ,  Gerhard Winter ,  Markus Hofer ,  Julia Myschik

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0002 ,  A61K31/137 ,  A61K31/138 ,  A61K31/245 ,  A61K31/285 ,  A61K31/40 ,  A61K31/485 ,  A61K38/00 ,  C07K14/43518

    摘要： The present invention relates to a method of producing and loading silk particles, preferably spider silk particles, with a compound. In particular, the present invention provides a novel two step method for loading silk particles, preferably spider silk particles, with small and water-soluble compounds. Also disclosed are silk particles, preferably spider silk particles, loaded with at least one compound which are eminently suited as carriers for controlled and sustained delivery applications. Furthermore, the invention relates to pharmaceutical or cosmetic compositions comprising said silk particles, preferably spider silk particles, and a pharmaceutically active compound or cosmetic compound for controlled and sustained release. The present invention is also directed to silk particles, preferably spider silk particles, loaded with a compound obtainable by the method according to the invention.

    摘要翻译： 本发明涉及一种用化合物生产和加载丝粒子，优选蜘蛛丝粒子的方法。 特别地，本发明提供了一种用于将丝状颗粒，优选蜘蛛丝颗粒加载到小的和水溶性化合物的新颖的两步法。 还公开了装载有至少一种非常适合用作控制和持续递送应用的载体的化合物的丝粒子，优选蜘蛛丝粒子。 此外，本发明涉及包含所述丝粒，优选蜘蛛丝颗粒的药物或化妆品组合物，以及用于受控和持续释放的药学活性化合物或化妆品化合物。 本发明还涉及装有可通过本发明方法获得的化合物的丝粒子，优选蜘蛛丝粒子。

    NICOTINE-CARRIER VACCINE FORMULATION
    37.
    发明申请
    NICOTINE-CARRIER VACCINE FORMULATION 审中-公开
    NICOTINE-CARRIER VACCINE配方

    公开(公告)号：US20090238797A1

    公开(公告)日：2009-09-24

    申请号：US12299487

    申请日：2007-05-11

    申请人： Rainer Lang ,  Gerhard Winter ,  Lorenz Vogt

    发明人： Rainer Lang ,  Gerhard Winter ,  Lorenz Vogt

    IPC分类号： A61K35/66 ,  A61K31/4439 ,  A61P25/34

    CPC分类号： A61K39/0013 ,  A61K9/19 ,  A61K2039/5258

    摘要： The present invention is in the fields of medicine, public health, vaccine and drug formulation. The invention provides composition formulations comprising a nicotine-carrier conjugate and a stabilizer, wherein said stabilizer comprises a non-reducing disaccharide and a non-ionic surfactant. The composition formulations are stable after a long time of storage at room temperature.

    摘要翻译： 本发明在医药，公共卫生，疫苗和药物制剂领域。 本发明提供了包含尼古丁 - 载体缀合物和稳定剂的组合物制剂，其中所述稳定剂包含非还原性二糖和非离子表面活性剂。 组合物制剂在室温下长时间储存​​后是稳定的。

    Method of stabilizing biologically active substances
    38.
    发明授权
    Method of stabilizing biologically active substances 有权
    稳定生物活性物质的方法

    公开(公告)号：US06689755B1

    公开(公告)日：2004-02-10

    申请号：US09184866

    申请日：1998-11-03

    申请人： Rolf-Dieter Gabel ,  Markus Mattern ,  Gerhard Winter ,  Alexander Wirl ,  Heinrich Woog

    发明人： Rolf-Dieter Gabel ,  Markus Mattern ,  Gerhard Winter ,  Alexander Wirl ,  Heinrich Woog

    IPC分类号： C08B3000

    CPC分类号： A61K9/1617 ,  A61K9/1623 ,  A61K47/183 ,  B01D1/18 ,  F26B3/02 ,  Y10S435/81 ,  Y10S514/911 ,  Y10S514/97

    摘要： The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture and drying the resulting mixture into a dry, amorphous product by means of convection drying. The invention also relates to the amorphous, microscopically homogeneous products which are obtained by this process, are in the form of powders and have a uniform geometric, in particular spherical, shape. The invention furthermore relates to the use of substance mixtures for stabilizing biologically active material, in particular proteins by means of spray drying.

    摘要翻译： 本发明涉及通过将生物活性物质与稳定混合物组合并通过对流干燥将所得混合物干燥成干燥的无定形产物来稳定生物活性物质的快速和容易重现的方法。 本发明还涉及通过该方法获得的无定形，微观均匀的产品，其为粉末形式并且具有均匀的几何形状，特别是球形的形状。 本发明还涉及物质混合物用于通过喷雾干燥来稳定生物活性物质，特别是蛋白质的用途。

    Electromagnetic transdermal injection device and methods related thereto
    40.
    发明授权
    Electromagnetic transdermal injection device and methods related thereto 失效
    电磁透皮注射装置及其相关方法

    公开(公告)号：US6074360A

    公开(公告)日：2000-06-13

    申请号：US897433

    申请日：1997-07-21

    申请人： Hans-Peter Haar ,  George B. Kirby Meacham ,  Manfred Beuttenmueller ,  Gerhard Winter ,  Markus Mattern

    发明人： Hans-Peter Haar ,  George B. Kirby Meacham ,  Manfred Beuttenmueller ,  Gerhard Winter ,  Markus Mattern

    IPC分类号： F41B6/00 ,  A61M5/30 ,  A61M31/00

    CPC分类号： F41B6/003 ,  A61M5/30

    摘要： Featured is a method for injection of a payload into the tissues of an organism or a body, including the steps of generating forces by electromagnetic repulsion and accelerating the payload to be injected, using the generated electromagnetic forces. The payload is thereby accelerated to a velocity sufficient for the payload to pass through the skin of the organism and be disposed in the subcutaneous tissues. The method further includes providing an electromagnetic force generating device that generates forces electromagnetically in a predetermined direction responsive to an electric current flowing through the device, wherein the step of generating includes passing an electric current through the electromagnetic force generating device to generate the electromagnetic repulsive forces used for accelerating the payload. Also featured is a electromagnetic force generating mechanism that includes a conductive member, which is configured so as to generate electromagnetic repulsive forces in a given direction to accelerate the payload responsive to a pulsed current passing through the conductive member. Additionally featured is an electromagnetic transdermal injection device including such an electromagnetic force generating mechanism, an electrical power supply and a switch that selectively interconnects the power supply and force generating mechanism to accelerate a payload such as a medicine.

    摘要翻译： 特征是将有效载荷注入生物或身体的组织的方法，包括通过电磁排斥产生力并使用产生的电磁力加速待注射的有效载荷的步骤。 因此有效载荷被加速到足以使有效载荷穿过生物体的皮肤并且被布置在皮下组织中的速度。 该方法还包括提供电磁力产生装置，其响应于流过该装置的电流而在预定方向上以电磁方式产生力，其中产生步骤包括使电流通过电磁力产生装置以产生电磁排斥力 用于加速有效载荷。 电磁力产生机构还包括导电构件，其被构造成在给定方向上产生电磁排斥力，以响应于穿过导电构件的脉冲电流来加速有效载荷。 另外特征在于包括这种电磁力产生机构的电磁透皮注射装置，电源和开关，其选择性地互连电源和力产生机构以加速诸如药物的有效载荷。