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    N-acylamino acid derivatives and their use
    34.
    发明授权
    N-acylamino acid derivatives and their use 失效
    N-酰基氨基酸衍生物及其用途

    公开(公告)号：US5481036A

    公开(公告)日：1996-01-02

    申请号：US179195

    申请日：1994-01-10

    申请人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

    发明人： Hajime Morishima ,  Yutaka Koike ,  Masato Nakano ,  Shugo Atsuumi ,  Seiichi Tanaka ,  Kenji Matsuyama

    IPC分类号： A61K31/195 ,  A61K31/535 ,  C07C59/66 ,  C07C317/00 ,  C07C317/44 ,  C07C323/43 ,  C07D207/08 ,  C07D211/14 ,  C07D215/12 ,  C07D233/54 ,  C07D239/38 ,  C07D257/04 ,  C07D265/30 ,  C07D285/12 ,  C07D285/125 ,  C07D295/084 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/18 ,  C07C321/00

    CPC分类号： C07D207/08 ,  C07C323/00 ,  C07C323/43 ,  C07C59/66 ,  C07D211/14 ,  C07D215/12 ,  C07D233/64 ,  C07D239/38 ,  C07D257/04 ,  C07D285/125 ,  C07D295/084 ,  C07D295/125 ,  C07D295/13 ,  C07D295/24 ,  C07D307/38 ,  C07D319/18 ,  C07D401/12 ,  C07F7/1856

    摘要： An N-acylamino acid derivative of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.6 is hydrogen lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from to 4 hetero atoms; each of R.sup.3 and R.sup.5 is hydrogen or lower alkyl; A is --CH(OH)--(CH.sub.2).sub.q R.sup.7 wherein R.sup.7 is hydrogen, lower alkyl, cycloalkyl, cyloalkylalkyl, aryl, aralkyl, a monocyclic or bicyclic heterocyclic group containing from to 4 hereto atoms or --E--R.sup.10 wherein E is --S(O).sub.i -- wherein i is 0, 1 or 2, oxygen, --NR.sup.11 -- wherein R.sup.11 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl, or ##STR2## wherein each of R.sup.12 and R.sup.13 is hydrogen, lower alkyl cycloalkyl, cycloalkylalkyl, aryl or aralkyl, and R.sup.10 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms provided that when R.sup.10 is hydrogen, i is 0, and a is an integer of from 0 to 5; or --CH.sub.2 --CHR.sup.8 --CO--R.sup.9 wherein R.sup.8 is hydrogen, lower alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a monocyclic or bicyclic heterocyclic group containing from 1 to 4 hetero atoms, and R.sup.9 is hydroxyl, --OX wherein X is alkyl, aryl, lower alkoxycarbonyloxyalkyl or 1-phthalidyl, or --N(Y.sup.1) (Y.sup.2) wherein each of Y.sup.1 and Y.sup.2 is hydrogen, lower alkyl, aryl, aralkyl or cycloalkyl, or Y and.sup.1 and Y.sup.2 form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may contain a further hereto atom; m is 0, 1 or 2; and n is an integer of from 1 to 5, provided that when R.sup.1 is hydrogen, m is 0; or a salt thereof, which is useful as hypotensive drugs.

    摘要翻译： 下式的N-酰基氨基酸衍生物：其中R 1，R 2，R 4和R 6各自为氢低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有4个杂原子的单环或双环杂环基 原子 R 3和R 5各自为氢或低级烷基; A是-CH（OH） - （CH 2）q R 7，其中R 7是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基，含有至4原子的单环或双环杂环基或-E-R 10，其中E是-S （O）i-其中i是0,1或2，氧，-NR 11 - ，其中R 11是氢，低级烷基，环烷基，环烷基烷基，芳基或芳烷基，或者其中R 12和R 13各自是氢， 环烷基，环烷基烷基，芳基或芳烷基，R 10为含有1至4个杂原子的氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或单环或双环杂环基，条件是当R 10为氢时，i为0， 是从0到5的整数; 或-CH 2 -CHR 8 -CO-R 9，其中R 8是氢，低级烷基，环烷基，环烷基烷基，芳基，芳烷基或含有1至4个杂原子的单环或双环杂环基，并且R 9是羟基， ，芳基，低级烷氧基羰氧基烷基或1-苯酞基，或-N（Y1）（Y2），其中Y1和Y2各自为氢，低级烷基，芳基，芳烷基或环烷基，或Y和1和Y2与相邻的氮原子一起形成 可含有其它原子的5-或6-元杂环基; m为0,1或2; 且n为1至5的整数，条件是当R 1为氢时，m为0; 或其盐，其可用作降压药物。

    Manufacturing method for sulfonic acid group-containing ether compound
    36.
    发明授权
    Manufacturing method for sulfonic acid group-containing ether compound 有权
    含磺酸基醚化合物的制备方法

    公开(公告)号：US08779184B2

    公开(公告)日：2014-07-15

    申请号：US13063563

    申请日：2009-09-14

    申请人： Masato Nakano ,  Akihiko Kanzaki ,  Takahiro Tsumori

    发明人： Masato Nakano ,  Akihiko Kanzaki ,  Takahiro Tsumori

    IPC分类号： C07C309/00

    CPC分类号： C07C309/20 ,  C07C303/02 ,  C07C309/09 ,  C08F216/1466

    摘要： The present invention provides a method for efficiently producing a sulfonic acid group-containing ether compound having a high purity and a good polymerizability while preventing production of a byproduct, and provides a sulfonic acid group-containing ether compound containing fewer impurities and having a good radical (co)polymerizability.The present invention provides a method of producing a sulfonic acid group-containing ether compound by reacting a sulfurous acid compound with a compound represented by the formula (1): wherein R1 represents a single bond, a CH2 group, or a CH2CH2 group, and R2 represents H, or a CH3 group, the method comprising the steps of: adjusting pH of a reaction system to 5.5 or greater with use of an alkaline substance; and adding the compound represented by the formula (1) to a reaction vessel containing the sulfurous acid compound.

    摘要翻译： 本发明提供了一种有效地制备具有高纯度和良好的聚合性同时防止副产物生成的含磺酸基的醚化合物的方法，并且提供了含少量杂质和具有良好基团的含磺酸基的醚化合物 （共）聚合性。 本发明提供一种通过使亚硫酸化合物与式（1）表示的化合物反应制备含磺酸基醚化合物的方法：其中R1表示单键，CH2基或CH2CH2基，和 R 2表示H或CH 3基团，该方法包括以下步骤：使用碱性物质将反应体系的pH调节至5.5以上; 并将由式（1）表示的化合物加入到含有亚硫酸化合物的反应容器中。

    METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN
    38.
    发明申请
    METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN 有权
    烯烃复合物和烯烃聚合方法

    公开(公告)号：US20110230622A1

    公开(公告)日：2011-09-22

    申请号：US13131301

    申请日：2009-12-14

    申请人： Masato Nakano ,  Hideshi Uchino ,  Naoshi Iwama ,  Masami Kashimoto ,  Tomohiro Kato

    发明人： Masato Nakano ,  Hideshi Uchino ,  Naoshi Iwama ,  Masami Kashimoto ,  Tomohiro Kato

    IPC分类号： C08F299/00 ,  C08F4/76 ,  C07F7/08 ,  B01J31/14 ,  B01J21/16

    CPC分类号： C07F17/00 ,  C08F4/65912 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/65927 ,  C08F4/65916 ,  C08F2/001 ,  C08F2500/01 ,  C08F210/16 ,  C08F210/08

    摘要： A metallocene complex by which high uptake efficiency of ethylene and/or α-olefin can be obtained compared with the conventional metallocene catalyst, and rubber component having high molecular weight can be polymerized, and polymerization method of olefin.Metallocene complex (metallocene complex having furyl or thienyl group in which substituent exists at 5-position of indenyl ring, and substituent may exist at 2-position of indenyl ring, and the like) represented by the general formula [I], the catalyst for olefin polymerization characterized by comprising said metallocene complex, and polymerization method of olefin characterized in that polymerization or copolymerization of olefin is carried out using said polymerization catalyst for olefin, and the like.

    摘要翻译： 与常规茂金属催化剂相比，可以获得乙烯和/或α-烯烃的高吸收效率的茂金属络合物，可以聚合具有高分子量的橡胶组分，以及烯烃的聚合方法。 茂金属络合物（具有呋喃基或噻吩基的茂金属络合物，其中在茚基环的5-位存在取代基，并且取代基可以存在于通式[I]表示的茚基环的2-位，等等），催化剂 其特征在于包含所述茂金属络合物和烯烃聚合方法，其特征在于使用所述烯烃聚合催化剂等进行烯烃的聚合或共聚。

    AUTOMATIC DISHWASHING COMPOSITION CONTAINING A SULFONATED COPOLYMER
    39.
    发明申请
    AUTOMATIC DISHWASHING COMPOSITION CONTAINING A SULFONATED COPOLYMER 有权
    自动洗涤组合物含有磺化共聚物

    公开(公告)号：US20110009303A1

    公开(公告)日：2011-01-13

    申请号：US12863844

    申请日：2009-03-27

    申请人： Takahiro Tsumori ,  Masato Nakano

    发明人： Takahiro Tsumori ,  Masato Nakano

    IPC分类号： C11D3/37 ,  C11D17/00 ,  C11D17/06

    CPC分类号： C11D3/2086 ,  C08J3/14 ,  C08L33/00 ,  C08L33/14 ,  C08L35/00 ,  C08L41/00 ,  C11D3/33 ,  C11D3/34 ,  C11D3/3757 ,  C11D3/378 ,  C11D3/3902 ,  C11D3/3942 ,  C11D3/3947 ,  C11D7/265 ,  C11D7/34 ,  C08L2666/04

    摘要： An ADW composition comprising a builder and a water-soluble copolymer which comprises: (a) from about 30 to 60 mol % of the copolymer having a structural unit originating from a monoethylenic unsaturated dicarboxylic acid (or dicarboxylate) monomer having 4 to 6 carbon atoms or its anhydride at; (b) from about 30 to 60 mol % of the copolymer having a structural unit originating from a monoethylenic unsaturated monocarboxylic acid (or monocarboxylate) monomer having 3 to 8 carbon atoms; and (c) from about 5 to 15 mol % of the polymer having a structural unit originating from a monoethylenic unsaturated monomer having a sulfonic (or sulfonate) group; wherein the water-soluble copolymer has a weight average molecular weight of from about 1,000 to about 50,000 wherein the copolymer is polymerized with hydrogen peroxide.

    摘要翻译： 一种包含助洗剂和水溶性共聚物的ADW组合物，其包含：（a）约30至60摩尔％的具有来自具有4-6个碳原子的单烯属不饱和二羧酸（或二羧酸酯）单体的结构单元的共聚物 或其酸酐在 （b）具有来自具有3-8个碳原子的单烯属不饱和一元羧酸（或单羧酸酯）单体的结构单元的共聚物的约30至60mol％; 和（c）约5至15摩尔％的具有源自具有磺酸（或磺酸盐）基团的单烯属不饱和单体的结构单元的聚合物; 其中所述水溶性共聚物的重均分子量为约1,000至约50,000，其中所述共聚物与过氧化氢聚合。

    COPOLYMER COMPOSITION AND METHOD OF PRODUCING THE COMPOSITION
    40.
    发明申请
    COPOLYMER COMPOSITION AND METHOD OF PRODUCING THE COMPOSITION 审中-公开
    共聚物组合物及其制备方法

    公开(公告)号：US20100298526A1

    公开(公告)日：2010-11-25

    申请号：US12740954

    申请日：2008-10-31

    申请人： Takahiro Tsumori ,  Masato Nakano

    发明人： Takahiro Tsumori ,  Masato Nakano

    IPC分类号： C08G75/00

    CPC分类号： C11D3/378 ,  C08F2/10 ,  C08F2/38 ,  C08F220/04 ,  C08F220/38 ,  C08F222/02

    摘要： Provided are a copolymer composition which can achieve a high level of compatibility between clay dispersibility under water having high hardness and an anti-iron deposition ability and is suitable for an additive for a detergent, and a method of producing the composition. The copolymer composition of the present invention includes a copolymer (P) which has a weight average molecular weight of 10,000 to 50,000 and contains a structural unit originating from a monoethylenic unsaturated dicarboxylic acid (or dicarboxylate) monomer (a) at 30 to 60 mol %, a structural unit originating from a monoethylenic unsaturated monocarboxylic acid (or monocarboxylate) monomer (b), and a structural unit originating from a sulfonic acid (or sulfonate) group-containing monomer (c) free of an ester bond and an amide bond, and a remaining monoethylenic unsaturated dicarboxylic acid (or dicarboxylate) monomer a content of which in terms of an acid is less than 12,000 ppm.

    摘要翻译： 提供一种共聚物组合物，其可以实现在具有高硬度和抗铁沉积能力的水下的粘土分散性之间的高水平的相容性，并且适用于洗涤剂用添加剂和制备该组合物的方法。 本发明的共聚物组合物包含重均分子量为10,000〜50,000的共聚物（P），含有以30〜60摩尔％的单烯属不饱和二羧酸（或二羧酸酯）单体（a）的结构单元， ，来自单烯属不饱和一元羧酸（或单羧酸酯）单体（b）的结构单元和源自不含酯键和酰胺键的含磺酸（或磺酸酯）基团的单体（c）的结构单元， 和剩余的单烯属不饱和二羧酸（或二羧酸酯）单体的含量以酸计小于12,000ppm。