公开(公告)号：US20080255570A1

公开(公告)日：2008-10-16

申请号：US12062345

申请日：2008-04-03

申请人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

发明人： Csaba Truckai ,  Robert Luzzi ,  John H. Shadduck

IPC分类号： A61B17/58 ,  A61B18/04

CPC分类号： A61B17/8836 ,  A61B17/8822 ,  A61B2017/00022

摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

公开(公告)号：US20080188851A1

公开(公告)日：2008-08-07

申请号：US12098560

申请日：2008-04-07

申请人： Csaba Truckai ,  John H. Shadduck ,  Bruno Strul

发明人： Csaba Truckai ,  John H. Shadduck ,  Bruno Strul

IPC分类号： A61B18/14

CPC分类号： A61B18/1445 ,  A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00125 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00404 ,  A61B2018/00601 ,  A61B2018/0063 ,  A61B2018/1412 ,  A61B2018/1455

摘要： An embodiment of the invention includes an electrosurgical jaw structure that carries cooperating PTC bodies in both series and parallel circuit components for controlled RF energy application to engaged tissue to effectively weld tissue.

摘要翻译： 本发明的实施例包括电外科钳口结构，其在串联和并联电路部件中携带协作的PTC体，用于受控RF能量施加到接合组织以有效地焊接组织。

公开(公告)号：US20080132899A1

公开(公告)日：2008-06-05

申请号：US11130837

申请日：2005-05-17

申请人： John H. Shadduck ,  Csaba Truckai

发明人： John H. Shadduck ,  Csaba Truckai

IPC分类号： A61B17/58

CPC分类号： A61L27/12 ,  A61B17/7095 ,  A61B17/8836 ,  A61B90/39 ,  A61L27/04 ,  A61L27/16 ,  A61L27/425 ,  A61L27/446 ,  A61L27/50 ,  A61L2430/02 ,  C08L33/12

摘要： This invention relates to implantable bone fill materials, systems and methods of treating bone abnormalities such as compression fractures of vertebrae, bone necrosis, bone tumors, cysts and the like. In an exemplary embodiment, the bone abnormality is accessed and a space is created by bone removal or compaction. An exemplary implant of the invention has a substantially fluid impermeable surface portion and an interior portion including an in-situ hardenable bone cement. The method of the invention includes applying energy to the fill material to accelerate polymerization and hardening of the material for supporting the bone.

摘要翻译： 本发明涉及可植入骨填充材料，治疗骨骼异常的系统和方法，例如椎骨压缩性骨折，骨坏死，骨肿瘤，囊肿等。 在一个示例性实施例中，访问骨异常并且通过骨移除或压实产生空间。 本发明的示例性植入物具有基本上不透流体的表面部分和包括原位可硬化骨粘固剂的内部部分。 本发明的方法包括向填充材料施加能量以加速用于支撑骨的材料的聚合和硬化。

公开(公告)号：US20070233148A1

公开(公告)日：2007-10-04

申请号：US11469769

申请日：2006-09-01

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61F2/00

CPC分类号： A61B17/8836 ,  A61B17/8811 ,  A61B17/8822 ,  A61B2017/00022 ,  A61B2017/00084 ,  A61B2090/064 ,  A61F2/44 ,  A61F2/4601

摘要： The present invention relates in certain embodiments to systems and methods for use in osteoplasty procedures, such as vertebral compression fractures. One system for injecting a bone fill material includes a container carrying a bone fill material. An elongated introducer configured for introduction into a vertebral body is coupleable to the container to allow a flow of the bone fill material therethrough. A cooling mechanism is coupled to the container and is configured to cool the bone fill material in the container to extend the working time of the bone fill material. One method for treating a vertebra includes providing a bone fill material, cooling the bone fill material to stall the polymerization of the bone fill material, heating the bone fill material to accelerate the polymerization of the bone fill material and delivering the bone fill material into a vertebral body.

摘要翻译： 本发明在某些实施例中涉及用于骨成形术程序（例如椎体压缩性骨折）的系统和方法。 一种用于注射骨填充材料的系统包括携带骨填充材料的容器。 构造成用于引入椎体的细长导引器可连接到容器以允许骨填充材料流过其中。 冷却机构联接到容器并且被配置为冷却容器中的骨填充材料以延长骨填充材料的工作时间。 治疗椎骨的一种方法包括提供骨填充材料，冷却骨填充材料以阻止骨填充材料的聚合，加热骨填充材料以加速骨填充材料的聚合并将骨填充材料输送到 椎体。

公开(公告)号：US07220261B2

公开(公告)日：2007-05-22

申请号：US11065180

申请日：2005-02-23

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B18/18

CPC分类号： A61B17/22004 ,  A61B18/042 ,  A61B2017/22008 ,  A61B2018/1213

摘要： A medical instrument coupled to first and second energy means and a computer controller for the controlled volumetric removal of thin tissue layers. The system provides a source for introducing a gas to controllably form and capture transient gas volumes in a microchannel structure at the working surface of the instrument that interfaces with a targeted tissue site. Each of the microchannel features of the working surface carries an electrode element coupled to the electrical source. The energy may be applied to the targeted site in either of two modes of operation, depending in part on voltage and repetition rate of energy delivery. In one mode of energy application, electrical potential is selected to cause an intense electrical arc across the transient ionized gas volumes to cause an energy-tissue interaction characterized by tissue vaporization. In another preferred mode of energy delivery, the system applies selected levels of energy to the targeted site by means of an energetic plasma at the instrument working surface to cause molecular volatilization of surface macromolecules thus resulting in material removal. Both modes of operation limit collateral thermal damage to tissue volumes adjacent to the targeted site. Another preferred embodiment provides and an ultrasound source or other vibrational source coupled to the working end to cause cavitation in fluid about the working end.

摘要翻译： 耦合到第一和第二能量装置的医疗器械和用于受控体积移除薄组织层的计算机控制器。 该系统提供用于引入气体的源，以可控地形成并捕获与目标组织部位相接触的仪器工作表面处的微通道结构中的瞬态气体体积。 工作表面的每个微通道特征带有耦合到电源的电极元件。 能量可以以两种操作模式中的任一种施加到目标位置，部分取决于能量传递的电压和重复率。 在一种能量应用模式中，选择电势以在瞬态电离气体体积上引起强烈的电弧以引起以组织蒸发为特征的能量 - 组织相互作用。 在另一种优选的能量输送模式中，系统通过仪器工作表面上的能量等离子体将选择的能量施加到目标部位，从而导致表面大分子的分子挥发，从而导致材料去除。 两种操作模式都限制了与目标部位相邻的组织体积的附带热损伤。 另一个优选实施例提供了耦合到工作端的超声源或其他振动源，以在工作端周围引起流体中的空化。

公开(公告)号：US07070597B2

公开(公告)日：2006-07-04

申请号：US10643787

申请日：2003-08-19

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00148 ,  A61B2018/0063

摘要： An electrosurgical working end for automatic modulation of active Rf density in a targeted tissue volume. The working end of the probe of the present invention defines a tissue-engagement surface of an elastomeric material with conductive elements that extend therethrough. In one embodiment, the expansion of the elastomeric material can de-couple the conductive elements from an interior electrode based temperature to modulate current flow. In another embodiment, the elastomeric material can couple and de-couple the conductive elements from an interior electrode based engagement pressure to modulate current flow.

摘要翻译： 用于自动调节靶组织体积中的活性Rf密度的电外科工作端。 本发明的探针的工作端限定弹性体材料的组织接合表面，其中导电元件延伸穿过其中。 在一个实施例中，弹性体材料的膨胀可以将导电元件从基于内部电极的温度解耦，以调制电流。 在另一个实施例中，弹性体材料可以将导电元件从内部基于电极的接合压力耦合和解耦，以调制电流。

公开(公告)号：US06958061B2

公开(公告)日：2005-10-25

申请号：US10456149

申请日：2003-06-05

申请人： Csaba Truckai ,  John H. Shadduck

发明人： Csaba Truckai ,  John H. Shadduck

IPC分类号： A61B17/12 ,  A61B18/18

CPC分类号： A61B17/12022 ,  A61B17/12045 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/12136 ,  A61B17/12168 ,  A61B17/12181 ,  A61B17/12186 ,  A61B2017/12068

摘要： A vaso-occlusive system comprising a catheter with a working end that carries a fluid media for introduction into an aneurysm. The fluid media carries a volume of microspheres, wherein each microsphere has a sacrificial shell or coating that surrounds an interior core portion of the microsphere. The core portions of the microspheres comprise either a first or second polymerizing composition, wherein interaction of such binary compositions will cause polymerization of the media into a gel or solid media that will occlude the aneurysm. An energy delivery means is provided within the catheter working end to cause removal of the sacrificial coatings of the volume of microspheres to thereby induce the polymerization process.

摘要翻译： 一种血管闭塞系统，包括具有工作端的导管，所述工作端承载用于引入动脉瘤的流体介质。 流体介质携带一定体积的微球体，其中每个微球体具有围绕微球体的内部核心部分的牺牲壳体或涂层。 微球的核心部分包括第一或第二聚合组合物，其中这种二元组合物的相互作用将引起培养基聚合成凝胶或固体培养基，其将闭塞动脉瘤。 在导管工作端内提供能量输送装置，以便移除体积的微球的牺牲涂层，从而引起聚合过程。

公开(公告)号：US06860601B2

公开(公告)日：2005-03-01

申请号：US10360091

申请日：2003-02-06

申请人： John H. Shadduck

发明人： John H. Shadduck

IPC分类号： A61F2/16 ,  G02C7/04 ,  G02C7/02

CPC分类号： G02C7/041 ,  A61F2/1451 ,  A61F2/1613 ,  A61F2/1635 ,  A61F2/1637 ,  A61F2210/0014 ,  G02C7/04 ,  G02C2202/22

摘要： An lens for correcting human vision, for example an IOL, contact lens or corneal inlay or onlay, that carries and interior phase or layer comprising a pattern of individual transparent adaptive displacement structures. In one embodiment, the displacement structures are actuated by a shape memory polymer (SMP) material or other polymer that is adjustable in shape in response to applied energy. The SMP can be designed to be selectively adjustable in volumetric dimension, modulus of elasticity and/or permeability. The adaptive optic means of the invention can be used to create highly localized surface corrections in the lens to correct higher order aberrations-which types of surfaces cannot be fabricated into and IOL and then implanted. The system of displacement structures also can provide spherical corrections in the lens.

摘要翻译： 用于校正人类视觉的镜片，例如IOL，隐形眼镜或角膜嵌体或镶嵌物，其携带和内部相或包含单独的透明自适应位移结构的图案的层。 在一个实施例中，位移结构由形状记忆聚合物（SMP）材料或响应于所施加的能量调节形状的其它聚合物致动。 SMP可以设计成可以选择性地调节体积尺寸，弹性模量和/或渗透性。 本发明的自适应光学装置可以用于在透镜中产生高度局部化的表面校正，以校正高阶像差 - 哪些类型的表面不能被制造和IOL然后植入。 位移结构的系统也可以在透镜中提供球面校正。

公开(公告)号：US06773409B2

公开(公告)日：2004-08-10

申请号：US09957529

申请日：2001-09-19

申请人： Csaba Truckai ,  John H. Shadduck ,  Bruno Strul

发明人： Csaba Truckai ,  John H. Shadduck ,  Bruno Strul

IPC分类号： A61B1804

CPC分类号： A61B17/320092 ,  A61B18/1442 ,  A61B18/18 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/22 ,  A61B2018/1455 ,  A61B2018/1876

摘要： A surgical system for controlled application of ultrasound energy to engaged tissue volumes for creating effective biological welds or seals in tissue. The invention provides an ultrasound transmission assembly including piezoelectric elements coupled to an elongate waveguide that is reciprocatable in an interior of an introducer. The reciprocatable waveguide assembly of the invention is adapted to have multiple functionality: (i) to couple ultrasound energy to both opposing jaws to thereby deliver energy to both sides of engaged tissues to create uniform thermal weld effects; (ii) to apply very high compressive forces to captured tissues over the length of elongate jaws by engaging substantially the entire length of the jaws, and (iii) to transect the captured tissues contemporaneous with the delivery of energy to create the thermal weld. The invention further provides for use of other energy sources to deliver thermal energy to tissue, for example microwave energy, Rf energy and laser energy, either in combination with ultrasound energy or independently.

摘要翻译： 一种外科系统，用于将受控的超声能量应用于接合的组织体积，以在组织中产生有效的生物学焊缝或密封。 本发明提供了一种超声波传输组件，其包括耦合到细长波导的压电元件，其可在导引器的内部中往复运动。 本发明的可往复波导组件适于具有多个功能：（i）将超声能量耦合到两个相对的钳口，从而将能量传递到啮合组织的两侧以产生均匀的热焊接效应; （ii）通过接合基本上整个长度的钳口，在延长的钳口的长度上对捕获的组织施加非常高的压缩力，并且（iii）在同时产生能量的同时延伸捕获的组织以产生热焊接。 本发明进一步提供了使用其他能量来组合超声能量或独立地将热能传递给组织，例如微波能量，Rf能量和激光能量。

公开(公告)号：US06740082B2

公开(公告)日：2004-05-25

申请号：US09222501

申请日：1998-12-29

申请人： John H. Shadduck

发明人： John H. Shadduck

IPC分类号： A61B1818

CPC分类号： A61N1/326 ,  A61B18/1485 ,  A61B18/1492 ,  A61B90/39 ,  A61B2018/00047 ,  A61B2018/00285 ,  A61B2018/00482 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00678 ,  A61B2018/00726 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2018/1861 ,  A61B2090/3782 ,  A61B2218/002

摘要： Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to “model” collagenous tissues of the LES by shrinking collagen fibers therein. Typically, an Rf source is connected to at least one conductive electrode that may be operated in a mono-polar or bi-polar fashion. A sensor array of individual sensors is provided in the working end. A computer controller is provided, which together with feedback circuitry, is capable of full process monitoring and control of: (i) power delivery; (ii) parameters of a selected therapeutic cycle, (iii) mono-polar or bi-polar energy delivery, and (iv) multiplexing of current flow between various paired electrodes. The controller can determine when the treatment is completed based on time, temperature, tissue impedance or any combination thereof.

摘要翻译： 用于热介导治疗患者下食管括约肌（LES）以诱导损伤愈合反应的仪器，从而用胶原基质填充LES的壁的细胞外隔室以提高LES的生物力学以提供增加的食管内压 用于防止酸反流。 优选的实施方案是用于经食道导入的双酚类装置，其携带用于将R f能量递送至LES（i）的壁的导电电极，以诱导损伤愈合反应或（ii）通过以下步骤“模拟”LES的胶原组织 在其中收缩胶原纤维。 通常，Rf源连接到可以以单极性或双极性方式操作的至少一个导电电极。 在工作端提供单独传感器的传感器阵列。 提供了一种计算机控制器，其与反馈电路一起能够进行全过程监控和控制：（i）功率传递; （ii）所选治疗周期的参数，（iii）单极性或双极能量递送，以及（iv）多个成对电极之间的电流的多路复用。 控制器可以基于时间，温度，组织阻抗或其任何组合来确定治疗何时完成。