公开(公告)号：US20130308635A1

公开(公告)日：2013-11-21

申请号：US13471527

申请日：2012-05-15

Applicant: Jeff Chen ,  Leo Cloutier

Inventor： Jeff Chen ,  Leo Cloutier

IPC: H04L12/56

CPC classification number: H04N21/2662 ,  H04N21/4147 ,  H04N21/633 ,  H04N21/6405 ,  H04N21/6408 ,  H04N21/6587 ,  H04N21/85403

Abstract: Mechanisms for initiating a unicast video stream in response to a triggering event from a client node receiving a multicast video stream are disclosed. A distribution node communicatively coupled to a plurality of client nodes multicasts a first video stream of a program encoded in a first format to the plurality of client nodes. The distribution node detects a triggering event associated with a first client node of the plurality of client nodes that is receiving the first video stream. In response to the triggering event, a second video stream of the program encoded in a second format is unicasted.

Abstract translation: 公开了响应来自接收多播视频流的客户端节点的触发事件发起单播视频流的机制。 通信地耦合到多个客户端节点的分发节点将以第一格式编码的节目的第一视频流多播到多个客户端节点。 分发节点检测与正在接收第一视频流的多个客户端节点中的第一客户机节点相关联的触发事件。 响应于触发事件，以第二格式编码的程序的第二视频流是单播的。

公开(公告)号：US20120245139A1

公开(公告)日：2012-09-27

申请号：US13487594

申请日：2012-06-04

Applicant: Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

Inventor： Suleyman Bahceci ,  William Bajjalieh ,  Jeff Chen ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Byung Gyu Kim ,  James W. Leahy ,  Matthew Sangyup Lee ,  Gary L. Lewis ,  Morrison B. Mac ,  Grace Mann ,  Charles K. Marlowe ,  Brian Hugh Ridgway ,  Joan C. Sangalang ,  Xian Shi ,  Craig Stacy Takeuchi ,  Yong Wang

IPC: A61K31/517 ,  A61P35/00 ,  A61K31/55 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/553

CPC classification number: C07D239/42 ,  C07D239/70 ,  C07D239/84 ,  C07D239/95 ,  C07D401/04 ,  C07D403/12

Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.

公开(公告)号：US08178570B2

公开(公告)日：2012-05-15

申请号：US10552424

申请日：2004-04-08

Applicant: Jeff Chen ,  Lisa Esther Dalrymple ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  James William Leahy ,  Brian Hugh Ridgway ,  Grace Mann ,  Larry W. Mann ,  Craig Stacy Takeuchi ,  Joan C. Sangalang

Inventor： Jeff Chen ,  Lisa Esther Dalrymple ,  Sergey Epshteyn ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  James William Leahy ,  Brian Hugh Ridgway ,  Grace Mann ,  Larry W. Mann ,  Craig Stacy Takeuchi ,  Joan C. Sangalang

IPC: A01N43/64 ,  A01N43/54 ,  A61K31/41 ,  C07D239/42 ,  C07D401/04 ,  C07D249/08

CPC classification number: C07D401/04 ,  A61K31/4439 ,  A61K31/506

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

公开(公告)号：US20120022065A1

公开(公告)日：2012-01-26

申请号：US13249815

申请日：2011-09-30

Applicant: Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takeuchi ,  Yong Wang ,  Wei Xu

Inventor： Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takeuchi ,  Yong Wang ,  Wei Xu

IPC: A61K31/5377 ,  A61K31/4709 ,  C07D239/94 ,  A61K31/517 ,  A61P35/00 ,  C07D413/14 ,  A61K31/497 ,  A61K31/513 ,  C12Q1/48 ,  C12N5/071 ,  C07D215/233 ,  C07D401/12

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。

公开(公告)号：US20110077233A1

公开(公告)日：2011-03-31

申请号：US12911442

申请日：2010-10-25

Applicant: Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takeuchi ,  Yong Wang ,  Wei Xu

Inventor： Lynne Canne Bannen ,  Diva Sze-Ming Chan ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Vasu Jammalamadaka ,  Richard George Khoury ,  James William Leahy ,  Morrison B. Mac ,  Grace Mann ,  Larry W. Mann ,  John M. Nuss ,  Jason Jevious Parks ,  Craig Stacy Takeuchi ,  Yong Wang ,  Wei Xu

IPC: A61K31/517 ,  C07D401/12 ,  A61K31/4709 ,  C07D417/12 ,  C07D403/12 ,  C07D239/94 ,  A61K31/47 ,  C07D413/12 ,  A61K31/5377 ,  A61P35/00 ,  A61P9/00 ,  A61P37/02 ,  A61P29/00 ,  C12Q1/48 ,  C12N5/02

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。

公开(公告)号：US20100136136A1

公开(公告)日：2010-06-03

申请号：US12443103

申请日：2007-09-28

Applicant: Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

Inventor： Adam Antoni Galan ,  Jeff Chen ,  Hongwang Du ,  Timothy Forsyth ,  Tai Phat Huynh ,  Henry William Beecroft Johnson ,  Patrick Kearney ,  James W. Leahy ,  Matthew Sangyup Lee ,  Grace Mann ,  Brian Hugh Ridgway ,  Craig Stacy Takeuchi ,  Peiwen Zhou

IPC: A61K31/4178 ,  C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  C12N5/00 ,  A61P35/00 ,  A61K31/7076 ,  A61K31/437 ,  A61K31/704 ,  A61K33/24

CPC classification number: C07D405/14 ,  C07D233/90 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

Abstract translation: 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。

公开(公告)号：US07704995B2

公开(公告)日：2010-04-27

申请号：US10513081

申请日：2003-05-02

Applicant: Chris A. Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Wang Co ,  Sergey Epshteyn ,  Abigail R Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Kumar Anand ,  Tsze H. Tsang ,  John M. Nuss ,  Csaba J Peto ,  Kenneth D. Rice ,  Mohamed Abdulkader Ibrahim ,  Kevin Luke Schnepp ,  Xian Shi ,  James William Leahy ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Grace Mann ,  Larry Wayne Mann ,  Craig Stacy Takeuchi ,  Peter Lamb ,  David J. Matthews ,  Nicole Miller

Inventor： Chris A. Buhr ,  Tae-Gon Baik ,  Sunghoon Ma ,  Zerom Tesfai ,  Longcheng Wang ,  Erick Wang Co ,  Sergey Epshteyn ,  Abigail R Kennedy ,  Baili Chen ,  Larisa Dubenko ,  Neel Kumar Anand ,  Tsze H. Tsang ,  John M. Nuss ,  Csaba J Peto ,  Kenneth D. Rice ,  Mohamed Abdulkader Ibrahim ,  Kevin Luke Schnepp ,  Xian Shi ,  James William Leahy ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Timothy Patrick Forsyth ,  Tai Phat Huynh ,  Grace Mann ,  Larry Wayne Mann ,  Craig Stacy Takeuchi ,  Peter Lamb ,  David J. Matthews ,  Nicole Miller

IPC: C07D279/16 ,  C07D279/12 ,  C07D417/12 ,  C07D265/36 ,  C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D419/12 ,  C07D241/18 ,  C07D241/20 ,  A61K31/55 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  C07D305/12 ,  C07D307/79 ,  A61K31/44 ,  A61P35/00

CPC classification number: C07D241/26 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12

Abstract: This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

Abstract translation: 本发明涉及用于调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物，以及含有这些化合物的药物组合物。 更具体地，本发明涉及抑制，调节和/或调节激酶，特别是检查点激酶，甚至更特别是检查点激酶1或Chk1的化合物。 治疗或预防性地使用化合物和组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面，并且包括通过以下方法治疗癌症以及与不期望的血管生成和/或细胞增殖相关的其它疾病状态， 施用有效量的这些化合物。

公开(公告)号：US20070159420A1

公开(公告)日：2007-07-12

申请号：US11306677

申请日：2006-01-06

Applicant: Jeff Chen ,  Xiaofang Suo

Inventor： Jeff Chen ,  Xiaofang Suo

IPC: G09G3/32 ,  G09G3/34 ,  F21S4/00

CPC classification number: F21K9/23 ,  F21K9/00 ,  F21Y2103/33 ,  F21Y2113/13 ,  F21Y2115/10

Abstract: Disclosed is a power LED light source that can be employed with different reflectors and other additional parts to form various power LED light units. Compared with the power LED light unit utilizing Luxeon LED packages and the like, the disclosed invention has the advantages of higher power, lower costs, better heat dissipation design and simpler optical design. The power LED light unit comprises of a base metal ring with multiple power LED dies mounted on it, one or more reflectors connected to the base metal ring, one or more extend metal rings connected to the base metal ring, a light unit base connected to the last extended metal ring, and a control circuit inside the metal rings. Such designed power LED light unit can emit light patterns such as parallel light pattern, non-parallel light pattern, and ring light pattern.

Abstract translation: 公开了一种功率LED光源，其可以与不同的反射器和其他附加部件一起使用以形成各种功率LED灯单元。 与使用Luxeon LED封装等的功率LED灯具相比，本发明具有功率更高，成本更低，散热设计更好，光学设计更简单的优点。 电源LED灯单元包括具有安装在其上的多个功率LED管芯的母金属环，连接到母金属环的一个或多个反射器，连接到母金属环的一个或多个延伸金属环，连接到 最后延伸的金属环和金属环内的控制电路。 这种设计的功率LED灯单元可以发射平行光图案，非平行光图案和环形光图案的光图案。

公开(公告)号：US20070109775A1

公开(公告)日：2007-05-17

申请号：US11279929

申请日：2006-04-17

Applicant: Jeff Chen

Inventor： Jeff Chen

IPC: F21L4/00

CPC classification number: F21V29/80 ,  F21L4/027 ,  F21V23/0414 ,  F21V23/0421 ,  F21V31/005 ,  F21Y2115/10 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73265 ,  H01L2924/181 ,  H01L2924/00014 ,  H01L2924/00012 ,  H01L2924/00

Abstract: Seven thermally and optically efficient LED units and two control units are disclosed. Flashlights utilizing these LED units and control units are also disclosed. Such a flashlight mainly includes a cylindrical housing, a cylindrical rear cap, one of the seven LED units, one of the two control units. Each LED units are interchangeable between different emitting colors. Each LED unit mainly comprises a metal base, a reflector if the metal base is not a reflector itself, a leadframe formed attaching one or more metal pins to a printed circuit board, one or more LED dies mounted on the metal base, optical material disposed over the LED dies, and an optional lens to further focus the light.

Abstract translation: 公开了七个热和光学有效的LED单元和两个控制单元。 还公开了利用这些LED单元和控制单元的手电筒。 这种手电筒主要包括圆柱形壳体，圆柱形后盖，七个LED单元中的一个，两个控制单元中的一个。 每个LED单元可以在不同的发光颜色之间互换。 每个LED单元主要包括金属基座，如果金属基座不是反射体本身的反射器，将一个或多个金属引脚连接到印刷电路板的引线框架，安装在金属基底上的一个或多个LED管芯，设置的光学材料 LED模组，以及可选镜头，以进一步对焦。

公开(公告)号：US20070054928A1

公开(公告)日：2007-03-08

申请号：US11586751

申请日：2006-10-26

Applicant: Lynne Bannen ,  Diva Chan ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Vasu Jammalamadaka ,  Richard Khoury ,  James Leahy ,  Morrison Mac ,  Grace Mann ,  Larry Mann ,  John Nuss ,  Jason Parks ,  Craig Takeuchi ,  Yong Wang ,  Wei Xu

Inventor： Lynne Bannen ,  Diva Chan ,  Jeff Chen ,  Lisa Dalrymple ,  Timothy Forsyth ,  Tai Huynh ,  Vasu Jammalamadaka ,  Richard Khoury ,  James Leahy ,  Morrison Mac ,  Grace Mann ,  Larry Mann ,  John Nuss ,  Jason Parks ,  Craig Takeuchi ,  Yong Wang ,  Wei Xu

IPC: A61K31/517 ,  A61K31/4709 ,  C07D403/02 ,  C07D401/02

CPC classification number: C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/22 ,  C07D215/36 ,  C07D215/38 ,  C07D215/46 ,  C07D239/88 ,  C07D239/94 ,  C07D295/15 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C12Q1/485 ,  G01N2500/04 ,  Y02A50/393

Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉 含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。