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98 条记录 (耗时 0.072 秒)

    Compositions for treatment and diagnosis of breast cancer and methods for their use
    31.
    发明授权
    Compositions for treatment and diagnosis of breast cancer and methods for their use 失效
    用于乳腺癌的治疗和诊断的组合及其使用方法

    公开(公告)号：US06518237B1

    公开(公告)日：2003-02-11

    申请号：US09389681

    申请日：1999-09-02

    申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/118

    摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

    摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

    Compositions for treatment and diagnosis of breast cancer and methods for their use
    33.
    发明授权
    Compositions for treatment and diagnosis of breast cancer and methods for their use 失效
    用于乳腺癌的治疗和诊断的组合及其使用方法

    公开(公告)号：US06387697B1

    公开(公告)日：2002-05-14

    申请号：US09222575

    申请日：1998-12-28

    申请人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    发明人： Jiang Yuqiu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu

    IPC分类号： C12N500

    CPC分类号： C12Q1/6886 ,  C12Q2600/158

    摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor antigen. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are provided, together with polynucleotides for preparing the inventive polypeptides. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer.

    摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明的化合物包括含有至少一部分乳腺肿瘤抗原的多肽。 提供包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸，以及用于制备本发明多肽的多核苷酸。 本发明的多肽可用于产生可用于诊断和监测乳腺癌的抗体。

    Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer
    35.
    发明授权
    Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer 失效
    前列腺癌的免疫治疗和免疫诊断的化合物和方法

    公开(公告)号：US6034218A

    公开(公告)日：2000-03-07

    申请号：US946026

    申请日：1997-10-07

    申请人： Steven G. Reed ,  Davin C. Dillon ,  Daniel R. Twardzik ,  Jennifer L. Mitcham

    发明人： Steven G. Reed ,  Davin C. Dillon ,  Daniel R. Twardzik ,  Jennifer L. Mitcham

    IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K14/82 ,  C07K14/00

    CPC分类号： C07K14/705 ,  C07K14/82 ,  A61K39/00

    摘要： Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

    摘要翻译： 提供了治疗和诊断前列腺癌的化合物和方法。 本发明化合物包括含有至少一部分前列腺蛋白质的多肽。 还提供了包含这样的多肽或编码这种多肽的DNA分子的前列腺癌的免疫治疗用疫苗和药物组合物。 本发明的多肽也可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。