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31.发明授权公开(公告)号：US08367588B2
公开(公告)日：2013-02-05
申请号：US11992341
申请日：2006-10-11
Applicant: Meng-Lin Tsao , Feng Tian , Peter Schultz
Inventor： Meng-Lin Tsao , Feng Tian , Peter Schultz
IPC: C40B50/06
CPC classification number: C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
Abstract: The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.
Abstract translation: 本发明涉及噬菌体展示多肽的翻译后修饰。 这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮氨基酸如对叠氮基-L-苯丙氨酸或炔基 - 氨基酸如对 - 炔丙氧基苯丙氨酸，其被并入噬菌体展示的融合物 通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统，在选定位置上的多肽。 这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。
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32.发明申请Selective Incorporation of 5-hydroxytryptophan into Proteins in Mammalian Cells 有权选择性将5-羟色氨酸并入哺乳动物细胞中的蛋白质公开(公告)号：US20120282626A1
公开(公告)日：2012-11-08
申请号：US13546582
申请日：2012-07-11
Applicant: Zhiwen Zhang , Lital Alfonta , Peter Schultz
Inventor： Zhiwen Zhang , Lital Alfonta , Peter Schultz
Abstract: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
Abstract translation: 本发明提供了使用正交氨酰基tRNA合成酶/ tRNA对将非天然氨基酸并入肽的方法和组合物。 特别地，提供了正交对以在由蛋白石突变编码的位置中并入5-羟基-L-色氨酸。
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公开(公告)号：USD662335S1
公开(公告)日：2012-06-26
申请号：US29373122
申请日：2011-03-02
Applicant: Peter Schultz
Designer： Peter Schultz
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公开(公告)号：USD662334S1
公开(公告)日：2012-06-26
申请号：US29373121
申请日：2011-03-02
Applicant: Peter Schultz
Designer： Peter Schultz
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公开(公告)号：US20110130988A1
公开(公告)日：2011-06-02
申请号：US13004677
申请日：2011-01-11
Applicant: RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
Inventor： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
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Patent Agency Ranking
公开(公告)号：US07915025B2
公开(公告)日：2011-03-29
申请号：US11800455
申请日：2007-05-04
Applicant: Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
Inventor： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC classification number: C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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公开(公告)号：USD615778S1
公开(公告)日：2010-05-18
申请号：US29315707
申请日：2009-07-16
Applicant: Peter Schultz
Designer： Peter Schultz
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38.发明授权Separation of propylene oxide from a mixture comprising propylene oxide and methanol 有权从包含环氧丙烷和甲醇的混合物中分离环氧丙烷公开(公告)号：US07692031B2
公开(公告)日：2010-04-06
申请号：US11631843
申请日：2005-07-06
Applicant: Hans-Georg Goebbel , Henning Schultz , Peter Schultz , Renate Patrascu , Malte Schulz , Meinolf Weidenbach
Inventor： Hans-Georg Goebbel , Henning Schultz , Peter Schultz , Renate Patrascu , Malte Schulz , Meinolf Weidenbach
IPC: C07D301/32
CPC classification number: C07D301/32 , C07D301/12
Abstract: A method of separating propylene oxide from a mixture (M) comprising propylene oxide and methanol, said method comprising: (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing an extracting solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column as top stream; (iv) withdrawing a bottoms stream from said extractive distillation column; (v) compressing the top stream obtained overhead in (iii) by means of at least one compressor to give a compressed vapor.
Abstract translation: 一种从包含环氧丙烷和甲醇的混合物（M）中分离环氧丙烷的方法，所述方法包括：（i）将所述混合物（M）引入萃取蒸馏塔; （ii）另外将萃取溶剂引入所述萃取蒸馏塔中; （iii）从所述萃取蒸馏塔顶部馏出环氧丙烷作为顶部流; （iv）从所述萃取蒸馏塔中取出塔底物流; （v）通过至少一个压缩机压缩在（iii）中获得的塔顶馏出物的顶部流以产生压缩蒸汽。
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公开(公告)号：US20080227152A1
公开(公告)日：2008-09-18
申请号：US11978156
申请日：2007-10-26
Applicant: Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan A. Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
Inventor： Peter Schultz , Lei Wang , John Christopher Anderson , Jason William Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan A. Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
IPC: C12P21/00
CPC classification number: C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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40.发明申请Separation of Propylene Oxide from a Mixture Comprising Propylene Oxide and Methanol 审中-公开从包含环氧丙烷和甲醇的混合物中分离出环氧丙烷公开(公告)号：US20070238888A1
公开(公告)日：2007-10-11
申请号：US11631630
申请日：2005-07-06
Applicant: Hans-Georg Goebbel , Henning Schultz , Peter Schultz , Renate Patrascu , Malte Schulz , Meinolf Weidenbach
Inventor： Hans-Georg Goebbel , Henning Schultz , Peter Schultz , Renate Patrascu , Malte Schulz , Meinolf Weidenbach
IPC: C07D301/32
CPC classification number: C07D301/32
Abstract: A method of separating propylene oxide from a mixture (M) comprising 5 to 50 percent by weight propylene oxide and 50 to 85 percent by weight methanol, said method comprising (i) introducing said mixture (M) into an extractive distillation column; (ii) additionally introducing a polar solvent into said extractive distillation column; (iii) distilling propylene oxide overhead from said extractive distillation column at a bottoms temperature of from 40 to 70° C. and at a pressure of from 300 to 750 mbar.
Abstract translation: 从包含5至50重量％的环氧丙烷和50至85重量％的甲醇的混合物（M）中分离环氧丙烷的方法，所述方法包括（i）将所述混合物（M）引入萃取蒸馏塔中; （ii）另外将极性溶剂引入所述萃取蒸馏塔中; （iii）在40至70℃的底部温度和300至750毫巴的压力下，从所述萃取蒸馏塔中蒸馏环氧丙烷塔顶馏出物。
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