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公开(公告)号：US07799009B2
公开(公告)日：2010-09-21
申请号：US11520382
申请日：2006-09-13
IPC分类号： A61B19/00
CPC分类号： B65D47/2031 , A61J1/1406 , A61J1/1468 , A61J1/201 , A61J1/2044 , A61J1/2075 , A61J1/2082 , A61J1/2089 , A61J1/2096
摘要： A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.
摘要翻译： 保护罩中包含或包含在防护罩中的小瓶可防止辐射从小瓶内容物中排出，从而屏蔽环境和人员免受辐照。 该小瓶可选地具有V形底部以允许抽出最大量的流体而不反转小瓶。 该小瓶配备有具有延伸到V形底部的流体取出尖端的小瓶接入适配器。 小瓶接入适配器可以通风或不通风。
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公开(公告)号：US07226577B2
公开(公告)日：2007-06-05
申请号：US10341577
申请日：2003-01-13
申请人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Natarajan Raju , Rolf E. Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Natarajan Raju , Rolf E. Swenson , Michael Tweedle
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , C07K7/086
摘要： New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N-O-P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.
摘要翻译： 用于具有式M-N-O-P-G的放射诊断成像或放射治疗的新的和改进的化合物，其中M是金属螯合剂（以与金属放射性核素复合的形式），N-O-P是接头，G是GRP受体靶向肽。 还提供了使用本发明的化合物使患者成像和/或向患者提供放射疗法的方法。 还提供了从化合物制备诊断显像剂的方法。 还提供了一种制备放射治疗剂的方法。
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33.发明授权Metal complexes derivatized with folate for use in diagnostic and therapeutic applications 失效用叶酸衍生的金属络合物用于诊断和治疗应用公开(公告)号：US07186397B2
公开(公告)日：2007-03-06
申请号：US09752867
申请日：2000-12-30
申请人： Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
发明人： Paul W. Wedeking , Ruth E. Wager , Thangavel Arunachalam , Kondareddiar Ramalingam , Karen E. Linder , Ramachandran S. Ranganathan , Adrian D. Nunn , Natarajan Raju , Michael F. Tweedle
CPC分类号： A61K49/10 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/146 , A61K51/0459 , A61K51/0497
摘要： Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
摘要翻译： 用于增强诊断或治疗剂的跨膜转运的复合物形式的诊断和治疗组合物及其使用方法。 复合物含有叶酸的叶酸受体结合类似物的α，γ或双异构体，被配体螯合的金属，在一个实施方案中，化学治疗剂。
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公开(公告)号：US5324824A
公开(公告)日：1994-06-28
申请号：US670458
申请日：1991-03-12
申请人： Alan B. Carpenter, Jr. , Leo J. Maheu , Michael A. Patz , Thomas H. Tulip , Karen E. Linder , Vinayakam Subramanyam , Jeffery S. Thompson
发明人： Alan B. Carpenter, Jr. , Leo J. Maheu , Michael A. Patz , Thomas H. Tulip , Karen E. Linder , Vinayakam Subramanyam , Jeffery S. Thompson
IPC分类号： A61K51/04 , C07F1/00 , C07F11/00 , C07F15/00 , C07F15/04 , C07F15/06 , C07C13/00 , A61K43/00 , B65D69/00
CPC分类号： C07F15/065 , A61K51/0476 , C07F1/005 , C07F11/005 , C07F15/0066 , C07F15/008 , C07F15/045 , A61K2123/00
摘要： A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrite.
摘要翻译： 一种从非极性配位体制备异氰酸酯配体和Tc，Ru，Co，Pt，Re，Os，Ir，W，Re，Cr，Mo，Mn，Ni，Rh，Nb和Ta的放射性同位素的配位络合物的方法， 异亚硝酸盐的放射性金属加合物。
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公开(公告)号：US5118797A
公开(公告)日：1992-06-02
申请号：US398879
申请日：1989-08-28
IPC分类号： C07F13/00
CPC分类号： C07F13/005
摘要： Rhenium tris dioxime complexes are useful in the synthesis of boronic acid adducts of rhenium dioxime complexes which are useful as radiotherapeutic agents.
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公开(公告)号：US08632753B2
公开(公告)日：2014-01-21
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US08409165B2
公开(公告)日：2013-04-02
申请号：US12848686
申请日：2010-08-02
IPC分类号： A61B19/00
CPC分类号： B65D47/2031 , A61J1/1406 , A61J1/1468 , A61J1/201 , A61J1/2044 , A61J1/2075 , A61J1/2082 , A61J1/2089 , A61J1/2096
摘要： A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.
摘要翻译： 保护罩中包含或包含在防护罩中的小瓶可防止辐射从小瓶内容物中排出，从而屏蔽环境和人员免受辐照。 该小瓶可选地具有V形底部以允许抽出最大量的流体而不反转小瓶。 该小瓶配备有具有延伸到V形底部的流体取出尖端的小瓶接入适配器。 小瓶接入适配器可以通风或不通风。
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公开(公告)号：US20110286929A1
公开(公告)日：2011-11-24
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US07922998B2
公开(公告)日：2011-04-12
申请号：US11165721
申请日：2005-06-24
申请人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
CPC分类号： A61K51/088 , A61K49/0002 , C07C269/04 , C07D257/00 , C07J41/0005 , C07J41/0011 , C07J43/003 , C07K14/57572 , C07C271/22
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
摘要翻译： 用于具有式MN-O-PG的诊断成像或治疗的新的和改进的化合物，其中M是具有以下结构的金属螯合剂：其中R1-R5和FG如本文所定义（以与金属放射性核素复合的形式或 不是），N-O-P是含有至少一个具有环状基团，至少一个取代的胆汁酸或至少一个非α氨基酸的非α氨基酸的接头，G是GRP受体靶向肽。 在优选的实施方案中，M是Aazta金属螯合剂或其衍生物。 还提供了使用本发明的化合物对患者成像和/或向患者提供放射治疗或光疗的方法。 还提供了用于从该化合物制备诊断显像剂的方法和试剂盒。 还提供了用于制备放射治疗剂的方法和试剂盒。
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公开(公告)号：US20110070165A1
公开(公告)日：2011-03-24
申请号：US12888736
申请日：2010-09-23
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。
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