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40 条记录 (耗时 0.07 秒)

    Power Adapter and Portable Computer
    32.
    发明申请
    Power Adapter and Portable Computer 有权
    电源适配器和便携式计算机

    公开(公告)号：US20120311354A1

    公开(公告)日：2012-12-06

    申请号：US13578649

    申请日：2011-01-28

    申请人： Ling Yao ,  Bo Song ,  Xiaoren Cheng ,  Weizhi Lin ,  Shuangcheng Zhao

    发明人： Ling Yao ,  Bo Song ,  Xiaoren Cheng ,  Weizhi Lin ,  Shuangcheng Zhao

    IPC分类号： G06F1/26

    CPC分类号： H02J9/005 ,  G06F1/26 ,  G06F1/28 ,  G06F1/32

    摘要： A power adapter for a portable computer includes a pulse width modulation unit and an output shaping unit and further includes a first judgment module that judges whether the portable computer is in a first state according to state judging parameters, and compares an output voltage with a first preset voltage and a second preset voltage when judging that the portable computer is in the first state, and acquires a judging result, wherein the first preset voltage is greater than or equal to the second preset voltage. The power adapter can increase efficiency.

    摘要翻译： 用于便携式计算机的电源适配器包括脉宽调制单元和输出整形单元，并且还包括第一判断模块，其根据状态判断参数判断便携式计算机是否处于第一状态，并将输出电压与第一 当判定便携式计算机处于第一状态时，预置电压和第二预设电压，并获取其中第一预置电压大于或等于第二预设电压的判断结果。 电源适配器可以提高效率。

    Fibrin-binding peptides and conjugates thereof
    33.
    发明授权
    Fibrin-binding peptides and conjugates thereof 有权
    纤维蛋白结合肽及其缀合物

    公开(公告)号：US08278274B2

    公开(公告)日：2012-10-02

    申请号：US12517239

    申请日：2007-12-11

    申请人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe Bussat ,  Bernard Lamy ,  Edmund R. Marinelli ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61K38/36

    CPC分类号： A61K49/14 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/085 ,  A61K49/124 ,  C07K7/06 ,  G01N33/532 ,  G01N33/574 ,  G01N33/86 ,  G01N2500/04

    摘要： Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

    摘要翻译： 提供了与先前已知的纤维蛋白结合肽相比具有高结合亲和力和优异物理特性的纤维蛋白结合肽。 这些纤维蛋白结合肽可以缀合到可检测标记或治疗剂，并用于检测和促进治疗与血纤维蛋白如血栓形成和血管生成和肿瘤状况有关的病理状况。 这些肽可以用于诸如MRI，超声和核医学成像（例如PET，闪烁照相成像等）的成像过程中。 肽也可以在治疗上使用。 本发明还提供了制备和使用这些肽及其缀合物的方法和方法。

    TARGETING VECTOR-PHOSPHOLIPID CONJUGATES
    34.
    发明申请
    TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 审中-公开
    靶向载体 - 磷脂结合体

    公开(公告)号：US20110286936A1

    公开(公告)日：2011-11-24

    申请号：US13160666

    申请日：2011-06-15

    申请人： Philippe BUSSAT ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe BUSSAT ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61K49/22 ,  A61P35/00 ,  C07K14/00

    CPC分类号： A61K49/227 ,  C07K14/00 ,  C07K14/52 ,  Y02A50/58

    摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

    摘要翻译： 提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。 肽载体可以与磷脂结合并包含在超声造影剂组合物中。 这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。 本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。 本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。

    TARGETING VECTOR-PHOSPHOLIPID CONJUGATES
    37.
    发明申请
    TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 有权
    靶向载体 - 磷脂结合体

    公开(公告)号：US20080152594A1

    公开(公告)日：2008-06-26

    申请号：US11954130

    申请日：2007-12-11

    申请人： Philippe Bussat ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    发明人： Philippe Bussat ,  Samir Cherkaoui ,  Hong (Helen) Fan ,  Bernard Lamy ,  Palaniappa Nanjappan ,  Radhakrishna K. Pillai ,  Sibylle Pochon ,  Bo Song ,  Rolf E. Swenson

    IPC分类号： A61B8/00 ,  A61P35/00 ,  C07K14/00

    CPC分类号： A61K49/227 ,  C07K14/00 ,  C07K14/52 ,  Y02A50/58

    摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

    摘要翻译： 提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。 肽载体可以与磷脂结合并包含在超声造影剂组合物中。 这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。 本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。 本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。