公开(公告)号：US20060068001A1

公开(公告)日：2006-03-30

申请号：US11280908

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060067999A1

公开(公告)日：2006-03-30

申请号：US11280382

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060062843A1

公开(公告)日：2006-03-23

申请号：US11274984

申请日：2005-11-16

申请人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

发明人： Deborah Sherman ,  John Clark ,  John Lamer ,  Steven White

IPC分类号： A61K9/28 ,  A61K9/62

CPC分类号： A61K9/1652 ,  A61K9/5047

摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.

公开(公告)号：US20060054317A1

公开(公告)日：2006-03-16

申请号：US11252650

申请日：2005-10-18

申请人： John Clark ,  Jamie Oag

发明人： John Clark ,  Jamie Oag

IPC分类号： E21B47/00

CPC分类号： E21B47/1015 ,  E21B43/11857 ,  E21B47/102

摘要： A method and apparatus for determining whether a tubing conveyed perforating (TCP) gun has fired by detecting a change in characteristics of the flow of an oil well. A method and apparatus detects the presence of fluorescent tracer dye to determine whether or not a TCP gun has fired. The method and apparatus detects a change is capacitance, or fiber optic electrical properties to determine whether or not a TCP gun has fired. The method and apparatus detects the number of charges fired to determine whether or not all TCP guns have fired and also provides a method and apparatus for determining the contributions of injection wells to producing wells by introducing fluorescent tracers into injection wells and detecting the presence of the fluorescent tracers at production wells. A method and apparatus is provided for placing fluorescent dye particles in a gravel pack to sense when a gravel pack is deteriorating by detecting the tracer dye particles in the well flow.

摘要翻译： 一种用于通过检测油井的流动特性的变化来确定输送穿孔（TCP）枪的管是否已经燃烧的方法和装置。 一种方法和装置检测荧光示踪剂染料的存在以确定TCP枪是否已经发射。 该方法和装置检测变化是电容或光纤电气性质，以确定TCP枪是否已经发射。 所述方法和装置检测所发射的电荷数以确定所有TCP枪是否已经发射，并且还提供了一种方法和装置，用于通过将荧光示踪剂引入注入井中来确定注入井对生产井的贡献，并检测是否存在 荧光示踪剂在生产井。 提供了一种方法和装置，用于将荧光染料颗粒放置在砾石包装中，以通过检测井流中的示踪染料颗粒来感测砾石包装是否变质。

公开(公告)号：US20050287581A1

公开(公告)日：2005-12-29

申请号：US11198685

申请日：2005-08-04

申请人： John Clark ,  Chris Denning

发明人： John Clark ,  Chris Denning

IPC分类号： A01K67/027 ,  A61K35/12 ,  A61P43/00 ,  C12N9/10 ,  C12Q1/68 ,  C07H21/04

CPC分类号： A01K67/0271 ,  A61K35/12 ,  C12N9/1051 ,  C12N2517/02

摘要： Sequence data for the sheep α(1,3)galactosyltransferase (α1,3GT) gene is provided in this disclosure, which allows the user to construct vectors for expressing or inactivating the α1,3GT gene. This in turn enables the user to control expression of the Galα(1,3)Gal xenoantigen on the surface of cells.

摘要翻译： 本公开提供了绵羊α（1,3）半乳糖基转移酶（α1,3GT）基因的序列数据，其允许用户构建用于表达或失活α1,3GT基因的载体。 这又使得用户能够控制细胞表面上Galalpha（1,3）Gal异种抗原的表达。

公开(公告)号：US06955217B2

公开(公告)日：2005-10-18

申请号：US10440514

申请日：2003-05-16

申请人： John Clark ,  Jamie Oag

发明人： John Clark ,  Jamie Oag

IPC分类号： E21B43/1185 ,  E21B47/10 ,  E21B43/116 ,  E21B43/119

CPC分类号： E21B47/1015 ,  E21B43/11857 ,  E21B47/102

摘要： A method and apparatus for determining whether a tubing conveyed perforating (TCP) gun has fired by detecting a change in characteristics of the flow of an oil well. A method and apparatus detects the presence of fluorescent tracer dye to determine whether or not a TCP gun has fired. The method and apparatus detects a change is capacitance, or fiber optic electrical properties to determine whether or not a TCP gun has fired. The method and apparatus detects the number of charges fired to determine whether or not all TCP guns have fired and also provides a method and apparatus for determining the contributions of injection wells to producing wells by introducing fluorescent tracers into injection wells and detecting the presence of the fluorescent tracers at production wells. A method and apparatus is provided for placing fluorescent dye particles in a gravel pack to sense when a gravel pack is deteriorating by detecting the tracer dye particles in the well flow.

摘要翻译： 一种用于通过检测油井的流动特性的变化来确定输送穿孔（TCP）枪的管是否已经燃烧的方法和装置。 一种方法和装置检测荧光示踪剂染料的存在以确定TCP枪是否已经发射。 该方法和装置检测变化是电容或光纤电气性质，以确定TCP枪是否已经发射。 所述方法和装置检测所发射的电荷数以确定所有TCP枪是否已经发射，并且还提供了一种方法和装置，用于通过将荧光示踪剂引入注入井中来确定注入井对生产井的贡献，并检测是否存在 荧光示踪剂在生产井。 提供了一种方法和装置，用于将荧光染料颗粒放置在砾石包装中，以通过检测井流中的示踪剂染料颗粒来感测砾石包装是否变质。

公开(公告)号：US20050223446P1

公开(公告)日：2005-10-06

申请号：US10815437

申请日：2004-03-30

申请人： John Clark ,  James Moore

发明人： John Clark ,  James Moore

IPC分类号： A01H5/00 ,  A01H5/08

CPC分类号： A01H6/7499 ,  A01H5/08

摘要： Description and specifications of a new and distinct blackberry variety which originated from seed produced by a a hand pollinated cross of Arapaho (U.S. Plant Pat. No. 8,510)×Arkansas selection 830 is provided. This new blackberry variety can be distinguished by its primocane-fruiting habit, potential high yields, medium to large fruit size, and good fruit quality.

摘要翻译： 提供了一种新的和不同的黑莓品种的描述和规格，这些品种源自由Arapaho（美国植物标准号：8,510）的手授粉杂交种子生产的种子，xArkansas选择830。 这种新的黑莓品种可以通过其原始果实的习惯，潜在的高产量，中等到大的水果尺寸和良好的果实质量来区分。

公开(公告)号：US20050160786A1

公开(公告)日：2005-07-28

申请号：US10962749

申请日：2004-10-13

申请人： Geof Brazier ,  John Clark ,  John Smallwood

发明人： Geof Brazier ,  John Clark ,  John Smallwood

IPC分类号： F16K17/16 ,  F16K37/00

CPC分类号： F16K17/16 ,  F16K37/005 ,  Y10T137/8158 ,  Y10T137/8326

摘要： A system and method for monitoring a pressure relief device are provided. The system includes a release sensor that provides an indication when the pressure relief device activates. A wireless transmitter is connected to the release sensor and sends a wireless transmission having an activation signal when the indication is provided by the release sensor. A receiver receives the wireless transmission from the transmitter and generates a warning when the activation signal is identified.

公开(公告)号：US20050143541A1

公开(公告)日：2005-06-30

申请号：US11027604

申请日：2004-12-28

申请人： Gregg Caldwell ,  John Clark ,  David Kinning ,  Alan Kirk ,  Thomas Klun ,  Ramesh Kumar ,  Roger Mader ,  George Moore ,  Zai-Ming Qiu ,  Richard Ross

发明人： Gregg Caldwell ,  John Clark ,  David Kinning ,  Alan Kirk ,  Thomas Klun ,  Ramesh Kumar ,  Roger Mader ,  George Moore ,  Zai-Ming Qiu ,  Richard Ross

IPC分类号： C07C69/653 ,  C07C233/18 ,  C07C271/08 ,  C07C271/20 ,  C07C271/28 ,  C07C311/04 ,  C07C311/09 ,  C08F20/24 ,  C08F220/38 ,  C08F114/18

CPC分类号： C08F220/38 ,  C07C271/20 ,  C07C271/28 ,  C07C311/09 ,  Y10T442/2287

摘要： Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: CnF2n+1—X—OH wherein:  R=hydrogen or an alkyl group of 1 to 4 carbon atoms,  m=2 to 8,  Rf═CnF2n+1,  y=0 to 6, and  q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.

摘要翻译： 氟代丙烯酸酯包括以下反应产物：（a）至少一种由下式表示的含氟醇：<？in-line-formula description =“In-line Formulas”end =“lead”？> C

公开(公告)号：US06858187B1

公开(公告)日：2005-02-22

申请号：US09959718

申请日：2000-05-09

申请人： Hannu Sipila ,  John Clark ,  Tom Wickstrom ,  Henri Tochon-Danguy

发明人： Hannu Sipila ,  John Clark ,  Tom Wickstrom ,  Henri Tochon-Danguy

IPC分类号： A61K51/00 ,  A61K51/12 ,  G01N23/00 ,  G01N37/00 ,  G01T1/164 ,  G21G1/10

CPC分类号： A61K51/1282 ,  A61K51/00 ,  A61K51/121 ,  Y10S422/903 ,  Y10T436/13

摘要： A device for preparing a radioactive water solution to be infused in a patient includes a reaction chamber (13) in which radioactive water vapour is formed by the catalysed reaction of oxygen gas containing oxygen-15 and hydrogen gas. A diffusion chamber (14) is provided which allows the radioactive water to penetrate, but which prevents the penetration of gasses. Tubes (26) and valves (16, 18) direct a sterile saline solution to the diffusion chamber (14), and then direct the saline solution containing radioactive water out from the diffusion chamber to a patient, or to a decay coil (22) being a part of the device. A measuring instrument is provided for measuring the radioactivity of the radioactive solution. The device is characterized in that the diffusion chamber (14), the tubes (26) the valves (16, 18), the radioactivity measuring instrument (17), and preferably also the reaction chamber 913), are mounted in the same frame 50, whereby they form a separate unit i.e. a water module (30), which as one entity can be detached from the lead shield (10) surrounding the device.

摘要翻译： 用于制备要输入患者的放射性水溶液的装置包括反应室（13），其中通过含有氧-15和氢气的氧气的催化反应形成放射性水蒸气。 提供扩散室（14），其允许放射性水渗透，但是防止气体渗透。 管（26）和阀（16,18）将无菌盐水溶液引导到扩散室（14），然后将含有放射性水的盐水溶液从扩散室引导至患者或衰变线圈（22） 作为设备的一部分。 提供了一种测量放射性溶液放射性的测量仪器。 该装置的特征在于，扩散室（14），管（26），阀（16,18），放射性测量仪器（17），并且优选地也是反应室913）安装在同一框架50 ，由此它们形成单独的单元，即水模块（30），其作为一个实体可以与围绕设备的铅屏蔽（10）分离。