公开(公告)号：US07897168B2

公开(公告)日：2011-03-01

申请号：US11735237

申请日：2007-04-13

申请人： Mingfei Chen ,  Peiwen Cheng ,  Ya Guo ,  Kishore Udipi

发明人： Mingfei Chen ,  Peiwen Cheng ,  Ya Guo ,  Kishore Udipi

IPC分类号： A61F2/00 ,  A61F2/82

CPC分类号： A61L31/148 ,  A61F2210/0004 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/402 ,  A61L2300/414 ,  A61L2300/432 ,  C08G63/08 ,  C08G63/823 ,  C09D167/04 ,  C08L67/04

摘要： Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.

摘要翻译： 本文公开了其上具有可控释放的可生物降解的聚合物涂层的可植入医疗装置，其中所述聚合物由γ-丁内酯的开环和至少一种选自三亚甲基碳酸酯，丙交酯，聚乙二醇，乙交酯的另外的单体形成，所形成的单体 由ε-己内酯，4-叔丁基己内酯和N-乙酰基己内酯的开环及其组合，以及可从生物可降解聚合物中释放的至少一种药物。 还公开了可生物降解聚合物的可植入医疗装置形式和形成聚合物的方法。

公开(公告)号：US20090232868A1

公开(公告)日：2009-09-17

申请号：US12049648

申请日：2008-03-17

申请人： Mingfei Chen ,  Peiwen Cheng

发明人： Mingfei Chen ,  Peiwen Cheng

IPC分类号： A61K9/00 ,  C08F118/02 ,  A61K39/395 ,  A61K31/7052 ,  A61K31/663 ,  A61K31/4353 ,  A61F2/82

CPC分类号： C08F8/30 ,  C08F218/08 ,  C08F220/18

摘要： Disclosed herein are biocompatible carbon-based nitric oxide (NO) donating polymers suitable for forming and coating medical devices. These polymers have acrylate backbones and are comprised of substantially hydrophobic monomers. The NO donating polymers are carbon based wherein the diazeniumdiolate group is attached to the acetate group on an acetate based monomer. Incorporating a vinyl acetate monomer into an acrylate based polymer allows diazeniumdiolation of a polymer that would otherwise not accommodate the diazeniumdiolate group.

摘要翻译： 本文公开了适用于形成和涂覆医疗器械的生物相容性碳基一氧化氮（NO）供体聚合物。 这些聚合物具有丙烯酸酯主链并且由基本疏水的单体组成。 NO供体聚合物是碳基，其中二氮烯鎓二醇基团连接到乙酸酯基单体上的乙酸酯基团。 将乙酸乙烯酯单体并入基于丙烯酸酯的聚合物允许聚合物的二氮烯鎓脱硫反应，否则不适合二氮烯二硫酸根基团。

公开(公告)号：US20080233168A1

公开(公告)日：2008-09-25

申请号：US12064105

申请日：2006-08-09

申请人： Peiwen Cheng ,  Mingfei Chen ,  Kishore Udipi

发明人： Peiwen Cheng ,  Mingfei Chen ,  Kishore Udipi

IPC分类号： A61F2/04 ,  A61F2/02 ,  A61K31/436

CPC分类号： A61L27/34 ,  A61K31/00 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08L67/04

摘要： Biodegradable polymers useful for fabricating implantable medical devices and as coatings for medical devices are provided. The biodegradable polymers are biocompatible and can be tuned to provide optimum bioactive agent elution rates as well as degradation rates. Also provided are methods for making medical devices and medical device coatings using the biodegradable polymers.

摘要翻译： 提供了可用于制造可植入医疗器械和医疗器械涂层的可生物降解聚合物。 可生物降解的聚合物是生物相容的并且可以被调整以提供最佳的生物活性剂洗脱速率以及降解速率。 还提供了使用可生物降解的聚合物制造医疗装置和医疗装置涂层的方法。

公开(公告)号：US20070244284A1

公开(公告)日：2007-10-18

申请号：US11279762

申请日：2006-04-14

申请人： Peiwen Cheng ,  Mingfei Chen ,  Kishore Udipi

发明人： Peiwen Cheng ,  Mingfei Chen ,  Kishore Udipi

IPC分类号： C08F118/02

CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  C08L33/14

摘要： Disclosed herein are biocompatible durable controlled drug releasing polymeric coatings for medical devices. The drug release rates of the polymers are controlled by adjusting monomer ratios and glass transition temperatures Tgs. The polymers are durable; they do not delaminate from the coated medical device.

摘要翻译： 本文公开了用于医​​疗装置的生物相容性耐用的药物释放聚合物涂层。 通过调节单体比率和玻璃化转变温度Tg来控制聚合物的药物释放速率。 聚合物耐用; 它们不会与涂覆的医疗装置分层。

公开(公告)号：US20060088571A1

公开(公告)日：2006-04-27

申请号：US10970171

申请日：2004-10-21

申请人： Mingfei Chen ,  Kishore Udipi ,  Peiwen Cheng ,  Ron Sundar

发明人： Mingfei Chen ,  Kishore Udipi ,  Peiwen Cheng ,  Ron Sundar

IPC分类号： C08F120/10 ,  A61F2/00

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings. Additional embodiments of the present invention include stents coated with the disclosed copolymer(s) and peptide drugs. Methods for treating or inhibiting post-stent implantation restenosis in patients are also provided.

摘要翻译： 公开了用于医​​疗装置的生物相容性涂层。 具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层。 本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。 本发明的另外的实施方案包括用公开的共聚物和肽药物涂覆的支架。 还提供了治疗或抑制患者支架后植入再狭窄的方法。

公开(公告)号：US06844409B2

公开(公告)日：2005-01-18

申请号：US10430953

申请日：2003-05-06

申请人： Christos Angeletakis ,  Mingfei Chen

发明人： Christos Angeletakis ,  Mingfei Chen

IPC分类号： C07F15/00 ,  A61K6/10 ,  C08G61/08 ,  C08G77/20 ,  C08G77/38 ,  C08L83/07 ,  C08G77/08

CPC分类号： C08L83/04 ,  A61K6/10 ,  C08G61/08 ,  C08G77/045 ,  C08G77/20 ,  C08K5/56

摘要： A composition curable by a metathesis reaction and comprising an olefin-containing resin system and metathesis catalyst. The resin system comprises siloxane-based oligomers or polymers end-capped and/or tethered with olefin functional groups that are capable of undergoing a metathesis reaction. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates the metathesis reaction of the composition. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenylethyl groups, a polydimethylsiloxane tethered and end-capped with norbornenylethyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenylethyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenylethyl groups. The catalyst may be, for example, a ruthenium carbene complex, such as 1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene) dichloro(o-isopropoxyphenylmethylene) ruthenium.

摘要翻译： 通过复分解反应可固化的组合物，其包含含烯烃的树脂体系和复分解催化剂。 树脂体系包含硅氧烷基低聚物或端基和/或与能够进行复分解反应的烯烃官能团连接的聚合物。 该组合物还包括钌卡宾络合物催化剂，由此催化剂引发组合物的复分解反应。 低聚物或聚合物可以是例如一种或其末端封端有降冰片烯乙基的遥爪聚二甲基硅氧烷，连接并用降冰片烯基乙基封端的聚二甲基硅氧烷，用降冰片烯乙基封端的三官能聚二甲基硅氧烷，或 用降冰片烯乙基封端的四官能聚二甲基硅氧烷。 催化剂可以是例如钌卡宾络合物，例如1,3-双 - （2,4,6-三甲基苯基）-2-（咪唑烷亚基）二氯（邻异丙氧基苯基亚甲基）钌。

公开(公告)号：US06649146B2

公开(公告)日：2003-11-18

申请号：US10010777

申请日：2001-12-06

申请人： Christos Angeletakis ,  Mingfei Chen

发明人： Christos Angeletakis ,  Mingfei Chen

IPC分类号： A61K716

CPC分类号： A61K6/10 ,  C08L51/085

摘要： A composition for use as a dental impression material including a polymerizable resin consisting of oligomers or polymers functionalized with groups curable by ring opening metathesis polymerization. These oligomers or polymers are end-capped and/or tethered with said functional groups. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates ring-opening metathesis polymerization of the composition. The invention includes a paste/paste system in which a base paste includes the polymerizable oligomer or polymer and an inorganic dental filler system and in which a catalyst paste includes the catalyst dissolved in an inert solvent and an inorganic dental filler system. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenyl groups, a polydimethylsiloxane tethered and end-capped with norbornenyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenyl groups. The catalyst may be, for example, a ruthenium carbene complex with a ligand having a basicity higher than tricyclohexylphosphine. The composition of the present invention exhibits reduced sensitivity to sulfur impurities.

公开(公告)号：US09056153B2

公开(公告)日：2015-06-16

申请号：US12414858

申请日：2009-03-31

申请人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

发明人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

IPC分类号： C08F220/26 ,  A61F2/04 ,  A61K31/436 ,  A61F2/06 ,  A61L31/04 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10

CPC分类号： A61L31/048 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  C08L33/06

摘要： The present disclosure generally relates to biocompatible polymers for coating or fabricating implantable medical devices and to implantable medical devices having the present biocompatible polymers. The disclosed biocompatible polymers exhibit superior biocompatibility and therefore minimize unwanted immune reaction from a patient into whom a medical device is implanted.

摘要翻译： 本公开内容通常涉及用于涂覆或制造可植入医疗装置的生物相容性聚合物和具有本生物相容性聚合物的可植入医疗装置。 所公开的生物相容性聚合物表现出优异的生物相容性，并且因此将植入医疗装置的患者的不希望的免疫反应最小化。

公开(公告)号：US08852620B2

公开(公告)日：2014-10-07

申请号：US11780713

申请日：2007-07-20

申请人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

发明人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

IPC分类号： A61F2/00 ,  A61L29/08 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L31/10 ,  A61L27/34

CPC分类号： A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/60 ,  A61L2420/02 ,  C08F220/12 ,  C08F226/10

摘要： Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.

摘要翻译： 公开了包含与具有药物溶解度梯度的聚合物混合的药物的药物递送系统和制备聚合物的方法。 还公开了具有其上包含药物溶解度梯度的聚合物和至少一种药物的涂层的医疗装置。

公开(公告)号：US08273828B2

公开(公告)日：2012-09-25

申请号：US11782146

申请日：2007-07-24

申请人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

发明人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

IPC分类号： C08F8/30 ,  C08F8/32 ,  C08L63/00 ,  A61L31/04

CPC分类号： C07C213/04 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  C08F8/30 ,  C08F8/32 ,  C08G63/6852 ,  C08G63/912 ,  C08F220/18 ,  C07C219/08

摘要： Biocompatible polymers having polymer backbones with at least one secondary amine suitable for diazeniumdiolation are disclosed. Specifically, methods for providing secondary amines-containing polymers using epoxide-opening reactions are provided. More specifically, nitric oxide-releasing medical devices made using these polymers are disclosed.

摘要翻译： 公开了具有聚合物主链与至少一种适用于二氮烯鎓脱硫的仲胺的生物相容性聚合物。 具体地说，提供了使用环氧化物开放反应提供含仲胺聚合物的方法。 更具体地，公开了使用这些聚合物制备的释放一氧化氮的医疗装置。