公开(公告)号：US08101565B2

公开(公告)日：2012-01-24

申请号：US11946026

申请日：2007-11-27

Applicant: Katsuyuki Murase ,  Syed F. A. Hossainy ,  Irina Astafieva ,  Li Zhao ,  Hong Ma

Inventor： Katsuyuki Murase ,  Syed F. A. Hossainy ,  Irina Astafieva ,  Li Zhao ,  Hong Ma

IPC: C07K14/00 ,  A61K38/00

CPC classification number: C07K7/08 ,  A61F2/95 ,  A61K9/1075 ,  A61K9/127 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/25 ,  A61L2300/802 ,  A61M25/1011 ,  A61M2025/0086 ,  A61M2025/105 ,  A61M2025/1075 ,  C07K7/06 ,  C07K14/775

Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

公开(公告)号：US08048948B2

公开(公告)日：2011-11-01

申请号：US12118677

申请日：2008-05-09

Applicant: Hiroshi Shimizu ,  Yongjin Li ,  Li Zhao

Inventor： Hiroshi Shimizu ,  Yongjin Li ,  Li Zhao

IPC: C08K3/34 ,  C08L67/04

CPC classification number: B29B7/90 ,  B29B7/14

Abstract: A melt-kneading method for filling material-containing resin or elastomer includes: a step of preparing a filling material as a filler and a resin or elastomer comprising an incompatible blend; and a step of introducing the filling material-containing resin or elastomer into a material feed part provided at an end of a cylindrical melt-kneading part having a heater and provided with a screw, and then melt-kneading the filling material-containing resin or elastomer under conditions where the rotation speed of the screw is about 600 rpm to about 3,000 rpm and its shear rate is about 900 to about 4,500 sec−1, thereby forming a co-continuous structure comprising the incompatible blend.

Abstract translation: 用于填充含材料的树脂或弹性体的熔融捏合方法包括：制备作为填料的填充材料的步骤和包含不相容的共混物的树脂或弹性体; 以及将含有填充材料的树脂或弹性体引入设置在具有加热器的圆筒形熔融混炼部件的端部的材料供给部分中，并且设置有螺杆，然后将含有填充材料的树脂或 弹性体，其中螺杆的旋转速度为约600rpm至约3,000rpm，其剪切速率为约900至约4,500sec -1，由此形成包含不相容共混物的共连续结构。

公开(公告)号：US07985727B1

公开(公告)日：2011-07-26

申请号：US11858851

申请日：2007-09-20

Applicant: Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

Inventor： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

IPC: A61K38/10 ,  A61K31/661

CPC classification number: A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。

公开(公告)号：US20110090920A1

公开(公告)日：2011-04-21

申请号：US12980682

申请日：2010-12-29

Applicant: Srihari Makineni ,  Ravi Iyer ,  Dave Minturn ,  Sujoy Sen ,  Donald Newell ,  Li Zhao

Inventor： Srihari Makineni ,  Ravi Iyer ,  Dave Minturn ,  Sujoy Sen ,  Donald Newell ,  Li Zhao

IPC: H04L12/66

CPC classification number: H04L45/74 ,  H04L49/20 ,  H04L69/16 ,  H04L69/161 ,  H04L69/166

Abstract: In general, in one aspect, the disclosures describes a method that includes receiving multiple ingress Internet Protocol packets, each of the multiple ingress Internet Protocol packets having an Internet Protocol header and a Transmission Control Protocol segment having a Transmission Control Protocol header and a Transmission Control Protocol payload, where the multiple packets belonging to a same Transmission Control Protocol/Internet Protocol flow. The method also includes preparing an Internet Protocol packet having a single Internet Protocol header and a single Transmission Control Protocol segment having a single Transmission Control Protocol header and a single payload formed by a combination of the Transmission Control Protocol segment payloads of the multiple Internet Protocol packets. The method further includes generating a signal that causes receive processing of the Internet Protocol packet.

Abstract translation: 一般来说，一方面，本公开内容描述了一种方法，其包括接收多个入口因特网协议分组，所述多个入口因特网协议分组中的每一个具有因特网协议报头和具有传输控制协议报头和传输控制的传输控制协议段 协议有效载荷，其中属于相同传输控制协议/因特网协议的多个分组流。 该方法还包括准备具有单个因特网协议报头的互联网协议分组和具有单个传输控制协议报头的单个传输控制协议段和由多个因特网协议分组的传输控制协议段有效载荷的组合形成的单个有效载荷 。 该方法还包括产生导致因特网协议分组的接收处理的信号。

公开(公告)号：US07921276B2

公开(公告)日：2011-04-05

申请号：US11726316

申请日：2007-03-21

Applicant: Ramesh Illikkal ,  Hari Kannan ,  Ravishankar Iyer ,  Donald Newell ,  Jaideep Moses ,  Li Zhao

Inventor： Ramesh Illikkal ,  Hari Kannan ,  Ravishankar Iyer ,  Donald Newell ,  Jaideep Moses ,  Li Zhao

IPC: G06F12/10

CPC classification number: G06F12/126

Abstract: In one embodiment, the present invention includes a translation lookaside buffer (TLB) having storage locations each including a priority indicator field to store a priority level associated with an agent that requested storage of the data in the TLB, and an identifier field to store an identifier of the agent, where the TLB is apportioned according to a plurality of priority levels. Other embodiments are described and claimed.

Abstract translation: 在一个实施例中，本发明包括具有存储位置的翻译后备缓冲器（TLB），每个存储位置包括优先级指示符字段以存储与请求TLB中的数据存储的代理相关联的优先级，以及存储 代理商的标识符，其中TLB根据多个优先级分摊。 描述和要求保护其他实施例。

公开(公告)号：US20090047318A1

公开(公告)日：2009-02-19

申请号：US11840119

申请日：2007-08-16

Applicant: Florian Niklas Ludwig ,  Syed Faiyaz Ahmed Hossainy ,  Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva

Inventor： Florian Niklas Ludwig ,  Syed Faiyaz Ahmed Hossainy ,  Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva

IPC: A61F13/00 ,  A61K31/56 ,  A61K36/13 ,  A61K38/00 ,  A61K9/127 ,  A61K9/50

CPC classification number: A61L31/10 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/51 ,  A61L31/16 ,  A61L2300/624 ,  A61L2300/626 ,  A61L2400/12

Abstract: Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.

Abstract translation: 公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。

公开(公告)号：US20080146489A1

公开(公告)日：2008-06-19

申请号：US11639512

申请日：2006-12-15

Applicant: Stephen D. Pacetti ,  Paul M. Consigny ,  Ronald W. Heil ,  Florian Niklas Ludwig ,  Dariush Davalian ,  Li Zhao ,  Irina Astafieva ,  Jinping Wan ,  Fozan El-Nounou ,  Katsuyuki Murase ,  Syed F.A. Hossainy ,  Rachel Bright ,  Jeffrey Ellis

Inventor： Stephen D. Pacetti ,  Paul M. Consigny ,  Ronald W. Heil ,  Florian Niklas Ludwig ,  Dariush Davalian ,  Li Zhao ,  Irina Astafieva ,  Jinping Wan ,  Fozan El-Nounou ,  Katsuyuki Murase ,  Syed F.A. Hossainy ,  Rachel Bright ,  Jeffrey Ellis

IPC: A61F2/06 ,  A61K31/27 ,  A61K31/44 ,  A61K31/56 ,  A61K31/66 ,  A61K38/02 ,  A61P9/00

CPC classification number: A61M25/1002 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/27 ,  A61K31/44 ,  A61K31/56 ,  A61K31/66 ,  A61K38/1709 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/112 ,  A61L2300/216 ,  A61L2300/252 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/62 ,  A61M25/10 ,  A61M37/0015 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/12

Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。

公开(公告)号：US20080040555A1

公开(公告)日：2008-02-14

申请号：US11503777

申请日：2006-08-14

Applicant: Ravishankar Iyer ,  Li Zhao ,  Srihari Makineni ,  Donald Newell

Inventor： Ravishankar Iyer ,  Li Zhao ,  Srihari Makineni ,  Donald Newell

IPC: G06F13/00 ,  G06F12/00

CPC classification number: G06F12/0811 ,  G06F12/0831

Abstract: In one embodiment, the present invention includes a method for maintaining data in a first level cache non-inclusively with data in a second level cache coupled to the first level cache. At the same time, at least a portion of directory information associated with the data in the first level cache may be maintained inclusively with a directory portion of the second level cache. Other embodiments are described and claimed.

Abstract translation: 在一个实施例中，本发明包括一种用于在与第一级高速缓存耦合的第二级高速缓存中的数据非包含地维护第一级高速缓存中的数据的方法。 同时，可以与第二级高速缓存的目录部分一起保持与第一级高速缓存中的数据相关联的目录信息的至少一部分。 描述和要求保护其他实施例。

公开(公告)号：US6032895A

公开(公告)日：2000-03-07

申请号：US219254

申请日：1998-12-22

Applicant: David A. Krula ,  Tom Kao ,  Li Zhao

Inventor： David A. Krula ,  Tom Kao ,  Li Zhao

IPC: G03B23/02 ,  G11B20060101

CPC classification number: G03B23/02

Abstract: A tape cartridge has a baseplate surrounded by a housing. Two hub pins are disposed within the housing substantially perpendicular to the baseplate. Each pin has top and bottom portions and a collared portion therebetween. The bottom portion of each pin is press-fitted into a mating aperture in the baseplate with the collared portion bearing against the baseplate. A large diameter tape hub is rotatably mounted on the top portion. The collared portions allow the hub pins to withstand heavy side loads without significantly deflecting from the perpendicular. Two large diameter tape hubs are rotatably mounted around the hub pins and improve the empty hub to full pack diameter ratios, and improve the resulting tangential drive force and tape tension profiles as the tape moves between the hubs. A back set of belt rollers includes a high-drag roller that engages the drive belt at a fixed wrap angle and produces a relatively constant drag. A front set of belt rollers includes a drive roller and has rollers mounted to form substantially equal geometries with rollers in the back set relative to the tape hubs. The constant wrap angle of a drive belt on the high-drag roller tends to outweigh varying drags from other rollers, causing less change in tape tension and tangential drive force as the tape is transferred from hub to hub in response to movement of the drive belt along a path in contact with the drive roller, the belt rollers, and the tape on the hubs.

Abstract translation: 磁带盒具有由壳体包围的基板。 两个毂销布置在壳体内基本垂直于底板。 每个销具有顶部和底部以及它们之间的套环部分。 每个销的底部被压配合到基板中的配合孔中，其中轴环部分抵靠基板。 大直径磁带轮毂可旋转地安装在顶部上。 轴环部分允许轮毂销承受重的侧向载荷，而不会明显地偏离垂直。 两个大直径的磁带轮毂可旋转地安装在轮毂销周围，并将空的轮毂改善成全包装直径比，并且随着带在轮毂之间移动而改善所产生的切向驱动力和带张力轮廓。 背面的一组皮带辊包括一个高牵引辊，它以固定的包角接合传动带并产生相对恒定的阻力。 前一组皮带辊包括驱动辊，并且具有安装的辊，以形成与后背组中的辊相对于带轮毂大致相等的几何形状。 驱动带在高牵引辊上的恒定包角倾向于超过其它辊的变化的拖动，从而当带根据传动带的移动将带从轮毂转移到轮毂时，带张力和切向驱动力的变化较小 沿着与驱动辊，带辊和轮毂上的带接触的路径。

公开(公告)号：USD1036105S1

公开(公告)日：2024-07-23

申请号：US29836686

申请日：2022-04-28

Applicant: Li Zhao

Designer： Li Zhao

Abstract: FIG. 1 is a front perspective view of a backpack showing my new design.
FIG. 2 is a front view of a backpack.
FIG. 3 is a rear view of a backpack.
FIG. 4 is a left side view of a backpack.
FIG. 5 is a right side view of a backpack.
FIG. 6 is a top view of a backpack; and,
FIG. 7 is a bottom view of a backpack.
Any shading and cross-hatching are not features of the design but are utilized to illustrate the surface contours of the backpack design in the drawings.
The broken lines depict stitching lines and form part of the claimed design.