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    Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction
    31.
    发明授权
    Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权
    使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震

    公开(公告)号：US08391979B2

    公开(公告)日：2013-03-05

    申请号：US12797793

    申请日：2010-06-10

    申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

    发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

    摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.

    摘要翻译： 一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出 信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激;以及处理器，其耦合到心脏电极和监测 模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态 响应于检测到的tis的速率中的至少一种的心律失常 检测氧合反应的下降和组织氧合恢复率。

    Implantable tissue perfusion sensing system and method
    33.
    发明授权
    Implantable tissue perfusion sensing system and method 有权
    植入式组织灌注感应系统及方法

    公开(公告)号：US08165662B2

    公开(公告)日：2012-04-24

    申请号：US12039281

    申请日：2008-02-28

    申请人： Can Cinbis ,  James K. Carney

    发明人： Can Cinbis ,  James K. Carney

    IPC分类号： A61B6/00

    CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

    摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.

    摘要翻译： 一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。 处理器响应于由检测器检测到的发射光来确定多个光测量，并且响应于以异常波长发射光的多个光源的光源产生血液体积指数。 然后利用血容量指数来验证心脏事件的识别。

    Tissue Oxygenation Monitoring in Heart Failure
    35.
    发明申请
    Tissue Oxygenation Monitoring in Heart Failure 有权
    心力衰竭组织氧合监测

    公开(公告)号：US20100317947A1

    公开(公告)日：2010-12-16

    申请号：US12797823

    申请日：2010-06-10

    申请人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

    发明人： Can Cinbis ,  James K. Carney ,  Jonathan L. Kuhn ,  David A. Anderson

    IPC分类号： A61B5/1455

    CPC分类号： A61N1/36557

    摘要： A medical device system and associated method control the delivery of a therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the therapy is adjusted in response to detecting the decreased tissue oxygenation.

    摘要翻译： 医疗装置系统和相关联的方法控制对患者的治疗的递送。 该系统包括活动传感器并检测患者的活动水平的变化。 该系统还包括用于感测对应于组织光衰减的信号的光学传感器。 响应于检测到活动水平的变化，系统计算组织氧合测量。 响应于检测到组织氧合减少而调整治疗递送的参数。

    Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction
    36.
    发明申请
    Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction 有权
    使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震

    公开(公告)号：US20100317946A1

    公开(公告)日：2010-12-16

    申请号：US12797781

    申请日：2010-06-10

    申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

    发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

    IPC分类号： A61B5/145 ,  A61B5/0402

    CPC分类号： A61N1/3622 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14542 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/3956

    摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.

    摘要翻译： 用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。 在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号 用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。 响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

    Implantable tissue perfusion sensing system and method
    39.
    发明授权
    Implantable tissue perfusion sensing system and method 有权
    植入式组织灌注感应系统及方法

    公开(公告)号：US08886465B2

    公开(公告)日：2014-11-11

    申请号：US12039263

    申请日：2008-02-28

    申请人： Can Cinbis ,  James K. Carney

    发明人： Can Cinbis ,  James K. Carney

    IPC分类号： G01N33/48 ,  A61B6/00

    CPC分类号： A61B5/1459 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/14542 ,  A61B5/7214 ,  A61N1/3925

    摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

    摘要翻译： 一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。 处理器响应于由检测器检测到的发射光来确定多个光测量，响应于检测到的发射光，针对多个波长中的每一个更新第一归一化系数和第二归一化系数，并且调整所确定的 响应于第一归一化系数和第二归一化系数的多个光测量。

    Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration
    40.
    发明授权
    Device and method for monitoring of absolute oxygen saturation and tissue hemoglobin concentration 有权
    用于监测绝对氧饱和度和组织血红蛋白浓度的装置和方法

    公开(公告)号：US08634890B2

    公开(公告)日：2014-01-21

    申请号：US12797744

    申请日：2010-06-10

    申请人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

    发明人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14552 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/7239 ,  A61N1/36557

    摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway at a plurality of wavelengths to generate corresponding first detected light intensity output signals, detects emitted light scattered by the volume of tissue delivered along a second pathway different from the first pathway at a plurality of wavelengths to generate corresponding second detected light intensity output signals, determines whether a difference between the emitted light detected along the first pathway and the emitted light detected along the second pathway is greater than a predetermined threshold, and alters sensing by the device in response to the determining whether a difference is greater than the predetermined threshold.

    摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径以多个波长传送的组织体积散射的发射光，以产生相应的第一检测到的光强度输出信号，以检测由沿着 在多个波长处与第一路径不同的第二路径以产生相应的第二检测光强度输出信号，确定沿着第一路径检测的发射光与沿着第二路径检测的发射光之间的差是否大于预定阈值 并且改变响应于确定差异是否大于预定阈值的设备的感测。