公开(公告)号：US20080261878A1

公开(公告)日：2008-10-23

申请号：US11976318

申请日：2007-10-23

申请人： Jurgen Gotz ,  Roger Nitsch ,  Feng Chen

发明人： Jurgen Gotz ,  Roger Nitsch ,  Feng Chen

IPC分类号： A61K38/00 ,  A61P25/00

CPC分类号： C07K14/4711 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0312 ,  A01K2267/0318 ,  C12N15/8509

摘要： The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative diseases associated with the formation of neurofibrillary tangles, in particular Alzheimer's disease. The present invention is based on the surprising-finding that injection of β-amyloid Aβ42 fibrils into brains of P301L mutant tau transgenic mice caused several-fold increases in the numbers and an accelerated production of neurofibrillary tangles in cell bodies predominantly within the amygdala. The induced neurofibrillary tangles occurred as early as 18 days after Aβ42 injections and displayed striking features of neurofibrillary tangles of several human neurodegenerative diseases, particularly Alzheimer's disease.

摘要翻译： 本发明公开了一种可用于鉴定和测试调节剂的方法和体内测定系统，以及用于验证与形成神经原纤维缠结，特别是阿尔茨海默病有关的神经变性疾病的疗法。 本发明基于令人惊奇的发现，即将β-淀粉样蛋白Aβ2-2原纤维注射到P301L突变体tau转基因小鼠的脑中导致数量增加数倍，并且加速了神经原纤维缠结的产生 细胞体主要位于杏仁核内。 诱导的神经原纤维缠结发生早于Abeta 42注射后18天，并显示几种人类神经变性疾病，特别是阿尔茨海默病的神经原纤维缠结的显着特征。

公开(公告)号：US20080241967A1

公开(公告)日：2008-10-02

申请号：US12069136

申请日：2008-02-06

申请人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

发明人： Feng Chen ,  A. B. Bodine ,  Paul L. Dawson ,  Thomas R. Scott ,  Xi Wang

IPC分类号： G01N33/536

CPC分类号： G01N33/54346

摘要： A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle—antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

摘要翻译： 公开了一种用于确定样品中感兴趣分析物的量的放射免疫测定方法。 感兴趣的分析物可以是抗原或其他化学实体。 使用抗原或其他实体的已知抗体并与功能化的纳米颗粒缀合。 由于本发明纳米颗粒 - 抗体缀合物表现出高表面积，本发明的放射免疫测定方法特别适用于低分子量化学品的定性和定量分析。

公开(公告)号：US07414450B2

公开(公告)日：2008-08-19

申请号：US11251107

申请日：2005-10-13

申请人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

发明人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

IPC分类号： H03H11/26 ,  G01R35/04

CPC分类号： H02M3/07

摘要： A system and method for adaptively providing a power supply voltage. The system includes an oscillator configured to receive an output voltage and generate a firs signal. The first signal is associated with a first frequency and a first period. Additionally, the system includes a frequency comparator configured to receive the first signal associated with the first frequency and a second signal associated with a second frequency and to generate a third signal if the first frequency and the second frequency are not equal, and a voltage regulator coupled to the frequency comparator and configured to generate the output voltage based on at least information associated with the third signal. The output voltage is received by a powered system, and the powered system is configured to receive a clock signal associated with a clock frequency. The clock frequency is equal to the second frequency.

摘要翻译： 一种用于自适应地提供电源电压的系统和方法。 该系统包括配置成接收输出电压并产生第一信号的振荡器。 第一信号与第一频率和第一周期相关联。 另外，该系统包括：频率比较器，被配置为接收与第一频率相关联的第一信号和与第二频率相关联的第二信号，并且如果第一频率和第二频率不相等则产生第三信号;以及电压调节器 耦合到频率比较器并被配置为基于至少与第三信号相关联的信息来产生输出电压。 输出电压由供电系统接收，并且供电系统被配置为接收与时钟频率相关联的时钟信号。 时钟频率等于第二个频率。

公开(公告)号：US20070262647A1

公开(公告)日：2007-11-15

申请号：US11743134

申请日：2007-05-01

申请人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

发明人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

IPC分类号： H02J1/10

CPC分类号： G06F1/26 ,  Y10T307/305 ,  Y10T307/383 ,  Y10T307/50

摘要： A system and method for adaptively providing a power supply voltage. The system includes an input/output subsystem configured to receive a first voltage, an analog subsystem configured to receive a second voltage and coupled to the input/output subsystem, a first digital subsystem configured to receive a third voltage and coupled to the input/output subsystem, and a second digital subsystem configured to receive a fourth voltage and coupled to the input/output subsystem, the first digital subsystem, and the analog subsystem. Additionally, the system includes a first adaptive power supply configured to receive an input voltage and generate the third voltage, and a second adaptive power supply configured to receive the input voltage and generate the fourth voltage.

摘要翻译： 一种用于自适应地提供电源电压的系统和方法。 该系统包括被配置为接收第一电压的输入/输出子系统，被配置为接收第二电压并耦合到输入/输出子系统的模拟子系统，被配置为接收第三电压并耦合到输入/输出的第一数字子系统 子系统和被配置为接收第四电压并耦合到输入/输出子系统，第一数字子系统和模拟子系统的第二数字子系统。 另外，该系统包括被配置为接收输入电压并产生第三电压的第一自适应电源，以及被配置为接收输入电压并产生第四电压的第二自适应电源。

公开(公告)号：US20070146999A1

公开(公告)日：2007-06-28

申请号：US11306369

申请日：2005-12-26

申请人： Yu-Chen Lin ,  Feng Chen

发明人： Yu-Chen Lin ,  Feng Chen

IPC分类号： H05K7/20

CPC分类号： H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

摘要： A heat dissipation device includes a retention module, a heat sink, a locking plate and a clip rotatably connecting with the retention module. The retention module includes an opening in a center thereof. The heat sink includes a heat conducting body and plurality of fins radially extending from the heat conducting body. The heat conducting body has a bottom portion received in the opening of the retention module. The locking plate engages with the bottom portion of the heat conducting body of the heat sink. The locking plate has a first portion abutting a bottom of the retention module, and a second portion opposite to the first portion. The second portion is pressed by a pressing portion of the clip when the heat dissipation device is at a locked position.

摘要翻译： 散热装置包括保持模块，散热器，锁定板和与保持模块可旋转地连接的夹子。 保持模块在其中心包括开口。 散热器包括导热体和从导热体径向延伸的多个翅片。 导热体具有容纳在保持模块的开口中的底部。 锁定板与散热片的导热体的底部接合。 锁定板具有邻接保持模块的底部的第一部分和与第一部分相对的第二部分。 当散热装置处于锁定位置时，第二部分被夹子的按压部分按压。

公开(公告)号：US07233868B2

公开(公告)日：2007-06-19

申请号：US11251583

申请日：2005-10-13

申请人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

发明人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

IPC分类号： G01R19/00 ,  G01R35/04

CPC分类号： G06F1/26 ,  Y10T307/305 ,  Y10T307/383 ,  Y10T307/50

摘要： A system and method for adaptively providing a power supply voltage. The system includes an input/output subsystem configured to receive a first voltage, an analog subsystem configured to receive a second voltage and coupled to the input/output subsystem, a first digital subsystem configured to receive a third voltage and coupled to the input/output subsystem, and a second digital subsystem configured to receive a fourth voltage and coupled to the input/output subsystem, the first digital subsystem, and the analog subsystem. Additionally, the system includes a first adaptive power supply configured to receive an input voltage and generate the third voltage, and a second adaptive power supply configured to receive the input voltage and generate the fourth voltage.

摘要翻译： 一种用于自适应地提供电源电压的系统和方法。 该系统包括被配置为接收第一电压的输入/输出子系统，被配置为接收第二电压并耦合到输入/输出子系统的模拟子系统，被配置为接收第三电压并耦合到输入/输出的第一数字子系统 子系统和被配置为接收第四电压并耦合到输入/输出子系统，第一数字子系统和模拟子系统的第二数字子系统。 另外，该系统包括被配置为接收输入电压并产生第三电压的第一自适应电源，以及被配置为接收输入电压并产生第四电压的第二自适应电源。

公开(公告)号：US20070058084A1

公开(公告)日：2007-03-15

申请号：US11251107

申请日：2005-10-13

申请人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

发明人： Wenzhe Luo ,  Paul Ouyang ,  Feng Chen

IPC分类号： H04N5/63

CPC分类号： H02M3/07

摘要： A system and method for adaptively providing a power supply voltage. The system includes an oscillator configured to receive an output voltage and generate a firs signal. The first signal is associated with a first frequency and a first period. Additionally, the system includes a frequency comparator configured to receive the first signal associated with the first frequency and a second signal associated with a second frequency and to generate a third signal if the first frequency and the second frequency are not equal, and a voltage regulator coupled to the frequency comparator and configured to generate the output voltage based on at least information associated with the third signal. The output voltage is received by a powered system, and the powered system is configured to receive a clock signal associated with a clock frequency. The clock frequency is equal to the second frequency.

摘要翻译： 一种用于自适应地提供电源电压的系统和方法。 该系统包括被配置为接收输出电压并产生第一信号的振荡器。 第一信号与第一频率和第一周期相关联。 另外，该系统包括：频率比较器，被配置为接收与第一频率相关联的第一信号和与第二频率相关联的第二信号，并且如果第一频率和第二频率不相等则产生第三信号;以及电压调节器 耦合到频率比较器并被配置为基于至少与第三信号相关联的信息来产生输出电压。 输出电压由供电系统接收，并且供电系统被配置为接收与时钟频率相关联的时钟信号。 时钟频率等于第二个频率。

公开(公告)号：US20060215787A1

公开(公告)日：2006-09-28

申请号：US11091227

申请日：2005-03-28

申请人： Zuoguo Wu ,  Feng Chen

发明人： Zuoguo Wu ,  Feng Chen

IPC分类号： H04L27/00

CPC分类号： H04L27/0002 ,  H03F3/45183 ,  H03F3/45968

摘要： According to one embodiment, a system, apparatus, and method for receiving high-speed signals using a receiver with a transconductance amplifier is presented. The apparatus comprises a transconductance amplifier to receive input voltage derived from an input signal, a clocked current comparator to receive output current from the transconductance amplifier, and a storage element to receive a binary value from the clocked current comparator.

摘要翻译： 根据一个实施例，提出了一种使用具有跨导放大器的接收机来接收高速信号的系统，装置和方法。 该装置包括跨导放大器以接收从输入信号导出的输入电压，时钟电流比较器以接收来自跨导放大器的输出电流，以及存储元件以从时钟电流比较器接收二进制值。

公开(公告)号：US20060120576A1

公开(公告)日：2006-06-08

申请号：US11269312

申请日：2005-11-08

申请人： Feng Chen

发明人： Feng Chen

IPC分类号： G06K9/00

CPC分类号： G06K9/00 ,  G06K9/00033 ,  G06K9/2036

摘要： A method and system for biometric identification utilizes structured light (e.g., fine grid) that is projected to the target objects (fingers and palm). The image with structured light on the object contours can give 3D information of the objects with resolution to satisfy NIST fingerprint standard. In embodiments, the structured light can be of different color, to reduce the burden of the software processing. To enhance the capture speed, a model with 2D image on “smooth” 3D surface can be used. In this “2.5-D” case, the finest feature of the structured light can be as big as millimeter size. Although grid-structured light can satisfy current requirement of fingerprint and palm print capture standards, in other embodiments, a customized structure based on the initial scan result can give optimal result on the 3D data. This may be useful when higher resolution is desired.

摘要翻译： 用于生物识别的方法和系统利用投射到目标对象（手指和手掌）的结构光（例如细网格）。 对象轮廓上的结构光图像可以给出具有分辨率的对象的3D信息，以满足NIST指纹标准。 在实施例中，结构化光可以具有不同的颜色，以减少软件处理的负担。 为了提高拍摄速度，可以使用“平滑”3D表面上的2D图像模型。 在这种“2.5-D”的情况下，结构光的最好的特征可以是毫米的大小。 虽然栅格结构的光可以满足指纹和掌纹捕获标准的当前要求，但在其他实施例中，基于初始扫描结果的定制结构可以在3D数据上给出最佳结果。 当需要更高分辨率时，这可能是有用的。

公开(公告)号：US07057540B2

公开(公告)日：2006-06-06

申请号：US10273217

申请日：2002-10-17

申请人： Khurram Muhammad ,  Robert B. Staszewski ,  Feng Chen ,  Dirk Leipold

发明人： Khurram Muhammad ,  Robert B. Staszewski ,  Feng Chen ,  Dirk Leipold

IPC分类号： H03M3/00

CPC分类号： H03M3/47 ,  H03M3/496 ,  H04B1/1036

摘要： A sigma-delta analog-to-digital converter-offers advantages such as noise shaping and high frequency operation. However, a sampling circuit needed to provide a highly oversampled discrete-time sample stream with low noise characteristics is difficult to design and implement. The present invention provides a sigma-delta mixer 300 with such a sampling circuit 310. The present invention discloses a sampling circuit using switched capacitors 307, 308, and 309 with low noise characteristics and at the same time is capable of providing a highly oversampled discrete-time sample stream.

摘要翻译： Σ-Δ模数转换器 - 具有噪声整形和高频操作等优点。 然而，需要提供具有低噪声特性的高度过采样离散时间采样流所需的采样电路难以设计和实现。 本发明提供了具有这种采样电路310的Σ-Δ混合器300。 本发明公开了一种使用具有低噪声特性的开关电容器307,308和309的采样电路，同时能够提供高度过采样的离散时间采样流。