公开(公告)号：US20170081359A1

公开(公告)日：2017-03-23

申请号：US15267995

申请日：2016-09-16

Applicant: Massachusetts Institute of Technology

Inventor： Dale Arlington Thomas, III ,  Alexander James Mijalis ,  Bradley L. Pentelute ,  Mark David Simon ,  Andrea Adamo ,  Patrick Louis Heider ,  Klavs F. Jensen

IPC: C07K1/08 ,  B01J19/24 ,  C07K14/61 ,  C07K7/06 ,  C07K14/62 ,  C07K14/47

CPC classification number: C07K1/084 ,  B01J19/24 ,  B01J2219/24 ,  C07K1/045 ,  C07K7/06 ,  C07K14/47 ,  C07K14/60 ,  C07K14/61 ,  C07K14/62

Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.

公开(公告)号：US20150285387A1

公开(公告)日：2015-10-08

申请号：US14420683

申请日：2013-08-09

Applicant: Massachusetts Institute of Technology

Inventor： Andrea Adamo ,  Alexander P. Clayton ,  Patrick Louis Heider ,  Nopphon Weeranoppanant ,  Klavs F. Jensen

IPC: F16K15/14

CPC classification number: F16K15/14 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0655 ,  F16K99/0015 ,  F16K99/0057 ,  Y10T137/7793 ,  Y10T137/87249

Abstract: Pressure control in fluidic systems is generally described. New trends in chemical synthesis involve the use of continuous reaction schemes, for example, in microfluidic and/or millifluidic devices. In many of these processes, it is often helpful to maintain controlled separation between two liquid phases and/or between a liquid phase and a gas phase. For example, in many processes, liquid-liquid and/or a gas-liquid separations are performed (e.g., between an aqueous and an organic phase)

Abstract translation: 通常描述流体系统中的压力控制。 化学合成的新趋势涉及使用连续反应方案，例如在微流体和/或微流体装置中。 在许多这些方法中，维持两个液相之间和/或在液相和气相之间的受控分离通常是有帮助的。 例如，在许多方法中，进行液 - 液和/或气 - 液分离（例如在水相和有机相之间）