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公开(公告)号：US20230130686A1
公开(公告)日：2023-04-27
申请号：US17509229
申请日：2021-10-25
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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公开(公告)号：US20220275021A1
公开(公告)日：2022-09-01
申请号：US17558525
申请日：2021-12-21
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20210188900A1
公开(公告)日：2021-06-24
申请号：US17127961
申请日：2020-12-18
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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4.发明授权公开(公告)号：US10780410B2
公开(公告)日：2020-09-22
申请号：US15504049
申请日：2015-08-14
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
IPC: B01J19/00 , B01J19/18 , A61K31/14 , A61K31/167
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US20140287509A1
公开(公告)日：2014-09-25
申请号：US14352354
申请日：2012-10-17
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
IPC: C12N5/071
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
Abstract translation: 一种用于引起细胞膜中的扰动的微流体系统，该系统包括限定内腔的微流体通道，并且被配置为使得悬浮在缓冲液中的细胞可以通过其中，其中微流体通道包括细胞变形收缩部，其中直径 收缩是细胞直径的函数。
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Patent Agency Ranking
公开(公告)号：US20240368216A1
公开(公告)日：2024-11-07
申请号：US18523727
申请日：2023-11-29
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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7.发明公开公开(公告)号：US20230201787A1
公开(公告)日：2023-06-29
申请号：US18086487
申请日：2022-12-21
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan Stuart Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
CPC classification number: B01J19/004 , B01J19/0093 , B01J19/18 , B01J2219/00799 , B01J2219/00011 , B01J2219/0004 , B01J2219/00795 , B01J2219/00806 , B01J2219/00813 , B01J2219/00907 , B01J2219/00909 , B01J2219/00918 , B01J2219/00831 , B01J2219/0081 , B01J2219/00833 , B01J2219/00873 , B01J2219/00817 , B01J2219/00822 , B01J2219/00986 , B01J2219/00835 , B01J2219/00889 , B01J2219/00871 , B01J2219/0002 , A61K31/14
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US20200277566A1
公开(公告)日：2020-09-03
申请号：US16818021
申请日：2020-03-13
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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9.发明申请公开(公告)号：US20190126229A1
公开(公告)日：2019-05-02
申请号：US16098333
申请日：2017-05-02
Applicant: Massachusetts Institute of Technology
Inventor： Andrea Adamo , Dale Arlington Thomas, III , Klavs F. Jensen , Timothy F. Jamison , Aaron A. Bedermann , Kosisochukwu C. Aroh
Abstract: The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.
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公开(公告)号：US09868759B2
公开(公告)日：2018-01-16
申请号：US14853683
申请日：2015-09-14
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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