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1.发明授权公开(公告)号：US11565230B2
公开(公告)日：2023-01-31
申请号：US16988827
申请日：2020-08-10
Applicant: Massachusetts Institute of Technology
Inventor： Klavs F. Jensen , Timothy F. Jamison , Allan S. Myerson , Jean-Christophe M. Monbaliu , Mohsen Behnam , Shin Yee Wong , Nopphon Weeranoppanant , Eve Marie Revalor , Torsten Stelzer , Jie Chen , Andrea Adamo , David R. Snead , Ping Zhang
IPC: B01J19/00 , B01J19/18 , A61K31/14 , A61K31/167
Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
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公开(公告)号：US11299698B2
公开(公告)日：2022-04-12
申请号：US15865901
申请日：2018-01-09
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Klavs F. Jensen , James Robbins Abshire , Jacquin Clarence Niles
Abstract: The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. Although delivery to some mammalian cells, such as cancer cell lines and fibroblasts had been previously demonstrated using this technique, those designs were incompatible with RBCs that have dramatically different physical properties. Through the use of smaller constriction sizes, high speeds and different buffers successful delivery to red blood cells can be achieved. By enabling robust delivery to red blood cells in a simple, scalable manner, the current subject matter can be implemented in a diversity of applications that deliver material to study red blood cell diseases and/or use red blood cells as a therapeutic platform. Related apparatus, systems, techniques, and articles are also described.
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公开(公告)号：US20220064584A1
公开(公告)日：2022-03-03
申请号：US17394125
申请日：2021-08-04
Inventor： Armon R. Sharei , Shirley Mao , George Hartoularos , Sophia Liu , Megan Heimann , Pamela Basto , Gregory Szeto , Siddharth Jhunjhunwala , Darrell J. Irvine , Robert S. Langer , Klavs F. Jensen , Ulrich H. Von Andrian
IPC: C12M1/42 , C12N15/87 , A61K39/00 , A61K45/06 , A61K49/00 , C12M3/06 , C12N5/0781 , C12N5/0783 , C12N5/0784 , G01N33/50
Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
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公开(公告)号：US10696944B2
公开(公告)日：2020-06-30
申请号：US14352354
申请日：2012-10-17
Applicant: Massachusetts Institute of Technology , Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Inventor： Armon R. Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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公开(公告)号：US20190093073A1
公开(公告)日：2019-03-28
申请号：US16141107
申请日：2018-09-25
Applicant: Massachusetts Institute of Technology
Inventor： Armon R Sharei , Andrea Adamo , Robert S. Langer , Klavs F. Jensen
Abstract: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
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Patent Agency Ranking
公开(公告)号：US10124336B2
公开(公告)日：2018-11-13
申请号：US14912001
申请日：2014-08-15
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , C12N5/09 , C12N5/078 , G01N15/14 , C12Q1/04 , G01N33/574 , G01N15/00 , B82Y30/00 , G01N1/30 , G01N15/10
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
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公开(公告)号：US20170081359A1
公开(公告)日：2017-03-23
申请号：US15267995
申请日：2016-09-16
Applicant: Massachusetts Institute of Technology
Inventor： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
CPC classification number: C07K1/084 , B01J19/24 , B01J2219/24 , C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62
Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.
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公开(公告)号：US20160193605A1
公开(公告)日：2016-07-07
申请号：US14912001
申请日：2014-08-15
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , G01N15/14 , G01N33/574 , C12Q1/04
CPC classification number: B01L3/502761 , B01L2200/0652 , B01L2300/08 , B01L2400/0487 , B82Y30/00 , C12N5/0634 , C12N5/0693 , C12Q1/04 , G01N1/30 , G01N15/1459 , G01N15/1484 , G01N33/574 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
Abstract translation: 基于所述细胞的物理性质分离或鉴定细胞可以包括提供细胞悬浮液; 将所述悬浮液通过包括收缩的微流体通道; 使细胞悬液通过狭窄; 并使所述细胞悬浮液与化合物接触。 与相对较小的细胞相比，收缩部的大小可优先变形相对较大的细胞。
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公开(公告)号：US20150285387A1
公开(公告)日：2015-10-08
申请号：US14420683
申请日：2013-08-09
Applicant: Massachusetts Institute of Technology
Inventor： Andrea Adamo , Alexander P. Clayton , Patrick Louis Heider , Nopphon Weeranoppanant , Klavs F. Jensen
IPC: F16K15/14
CPC classification number: F16K15/14 , B01L3/502723 , B01L3/502738 , B01L2200/0673 , B01L2200/0684 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2400/0487 , B01L2400/0655 , F16K99/0015 , F16K99/0057 , Y10T137/7793 , Y10T137/87249
Abstract: Pressure control in fluidic systems is generally described. New trends in chemical synthesis involve the use of continuous reaction schemes, for example, in microfluidic and/or millifluidic devices. In many of these processes, it is often helpful to maintain controlled separation between two liquid phases and/or between a liquid phase and a gas phase. For example, in many processes, liquid-liquid and/or a gas-liquid separations are performed (e.g., between an aqueous and an organic phase)
Abstract translation: 通常描述流体系统中的压力控制。 化学合成的新趋势涉及使用连续反应方案，例如在微流体和/或微流体装置中。 在许多这些方法中，维持两个液相之间和/或在液相和气相之间的受控分离通常是有帮助的。 例如，在许多方法中，进行液 - 液和/或气 - 液分离（例如在水相和有机相之间）
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公开(公告)号：US20240368216A1
公开(公告)日：2024-11-07
申请号：US18523727
申请日：2023-11-29
Applicant: Massachusetts Institute of Technology
Inventor： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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