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公开(公告)号：US09868759B2
公开(公告)日：2018-01-16
申请号：US14853683
申请日：2015-09-14
发明人： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
摘要： Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20210047365A1
公开(公告)日：2021-02-18
申请号：US16874824
申请日：2020-05-15
发明人： Dale Arlington Thomas , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K14/60 , C07K7/06 , C07K14/47 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/487
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.
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公开(公告)号：US20170081359A1
公开(公告)日：2017-03-23
申请号：US15267995
申请日：2016-09-16
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
CPC分类号： C07K1/084 , B01J19/24 , B01J2219/24 , C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62
摘要： Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.
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公开(公告)号：US20170081358A1
公开(公告)日：2017-03-23
申请号：US15268032
申请日：2016-09-16
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K14/47 , C07K14/61 , G01N21/33 , G01N33/487 , G01N21/27 , G01N21/3577 , C07K7/06 , C07K14/62
CPC分类号： C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , G01N21/272 , G01N21/33 , G01N21/3577 , G01N33/48707 , G01N2021/8416
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.
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公开(公告)号：US12043646B2
公开(公告)日：2024-07-23
申请号：US18068838
申请日：2022-12-20
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , G01N21/27 , G01N21/33 , G01N21/3577 , G01N21/84 , G01N33/487
CPC分类号： C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/48707 , G01N21/272 , G01N21/3577 , G01N2021/8416
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.
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公开(公告)号：US20230279045A1
公开(公告)日：2023-09-07
申请号：US18068838
申请日：2022-12-20
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K14/60 , C07K7/06 , C07K14/47 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/487
CPC分类号： C07K1/045 , C07K14/60 , C07K7/06 , C07K14/47 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/48707 , G01N2021/8416
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.
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公开(公告)号：US20220275021A1
公开(公告)日：2022-09-01
申请号：US17558525
申请日：2021-12-21
发明人： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
摘要： Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20210188900A1
公开(公告)日：2021-06-24
申请号：US17127961
申请日：2020-12-18
发明人： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
摘要： Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US11878996B2
公开(公告)日：2024-01-23
申请号：US17127951
申请日：2020-12-18
发明人： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
CPC分类号： C07K1/045 , B01J8/00 , B01J19/00 , B01J19/0053 , C07K1/04 , C07K1/042 , C07K1/061 , C07K1/08
摘要： Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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公开(公告)号：US20210188899A1
公开(公告)日：2021-06-24
申请号：US17127951
申请日：2020-12-18
发明人： Mark David Simon , Bradley L. Pentelute , Andrea Adamo , Patrick Louis Heider , Klavs F. Jensen
摘要： Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
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