-
公开(公告)号：US4517686A
公开(公告)日：1985-05-21
申请号：US405239
申请日：1982-08-04
IPC分类号： C07K14/78 , A61F1/00 , A61K37/00 , C07C103/52 , C07G7/00
CPC分类号： C07K14/78
摘要： A polypeptide having the cell-attaching activity of fibronectin. The polypeptide has 108 amino acid residues and the formula: H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala-Ala-Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr-Tyr-Arg-Ile-Thr-Tyr-Gly-Glu-Thr-Gly-Gly-Asn-Ser-Pro-Val-Gln-Glu-Phe-Thr-Val-Pro-Gly-Ser-Lys-Ser-Thr- la-Thr-Ile-Ser-Gly-Leu-Lys-Pro-Gly-Val-Asp-Tyr-Thr-Ile-Thr-Val-Tyr-Ala-Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro-Ile-Ser-Ile-Asn-Tyr-Arg-Thr-Glu-Ile-Asp-Lys-Pro-Ser-Gln-Met-OH. The polypeptide or a biologically active fragment thereof can be employed in the preparation of substrata designed for the attachment of cells thereto. It can be linked to the surface of a prosthetic device to particularly attract endothelial cells and fibroblastic cells.
摘要翻译： 具有纤连蛋白的细胞附着活性的多肽。 该多肽具有108个氨基酸残基，并且具有下式：H-Ile-Gly-Gln-Gln-Ser-Thr-Val-Ser-Asp-Val-Pro-Arg-Asp-Leu-Glu-Val-Val-Ala-Ala -Thr-Pro-Thr-Ser-Leu-Leu-Ile-Ser-Trp-Asp-Ala-Pro-Ala-Val-Thr-Val-Arg-Tyr-Tyr-Arg-Ile-Thr-Tyr-Gly- Glu-Thr-Gly-Gly-Asn-Ser-Pro-Val-Gln-Glu-Phe-Thr-Val-Pro-Gly-Ser-Lys-Ser-Thr-la-Thr-Ile-Ser-Gly-Leu- Lys-Pro-Gly-Val-Asp-Tyr-Thr-Ile-Thr-Val-Tyr-Ala -Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro- Ile-Ser-Ile-Asn-T yr-Arg-Thr-Glu-Ile-Asp-Lys-Pro-Ser-Gln-Met-OH。 多肽或其生物活性片段可用于制备为细胞附着而设计的基质。 它可以连接到假体装置的表面以特别吸引内皮细胞和成纤维细胞。
-
32.发明授权Collagen/glycosaminoglycan matrix stable to sterilizing by electron beam radiation 有权胶原/糖胺聚糖基质通过电子束辐射灭菌稳定公开(公告)号：US06969523B1
公开(公告)日：2005-11-29
申请号：US10002653
申请日：2001-10-19
申请人： Ralph-Heiko Mattern , Michael D. Pierschbacher , Fred Cahn , Juerg Friederich Tschopp , Timothy Irvin Malaney
发明人： Ralph-Heiko Mattern , Michael D. Pierschbacher , Fred Cahn , Juerg Friederich Tschopp , Timothy Irvin Malaney
IPC分类号： B31D5/00 , A61F2/00 , A61L27/26 , A61L27/60 , B31F1/00 , C12N5/00 , C12N5/06 , C12N5/08 , C12N11/02
CPC分类号： A61L27/26 , A61L27/60 , C12N5/0068 , C12N2533/54 , C12N2533/70 , C08L5/00 , C08L83/04 , C08L89/06
摘要： Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal sterilization. Also provided are methods for producing these compositions and terminally sterilized matrices or scaffolds from these compositions as well as methods of using these matrices or scaffolds as tissue engineering devices.
摘要翻译： 提供交联胶原蛋白和糖胺聚糖的组合物，其保留特征，使得它们可用作终末灭菌后的组织工程基质或支架。 还提供了用于从这些组合物生产这些组合物和终末灭菌的基质或支架的方法以及使用这些基质或支架作为组织工程装置的方法。
-
公开(公告)号：US06353090B1
公开(公告)日：2002-03-05
申请号：US09366991
申请日：1999-08-04
IPC分类号： A61K3800
摘要： Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.
-
公开(公告)号：US6020460A
公开(公告)日：2000-02-01
申请号：US357067
申请日：1994-12-14
IPC分类号： A61L27/00 , A61K38/00 , B31B50/06 , B65H3/06 , B65H7/18 , C07K1/02 , C07K5/08 , C07K5/10 , C07K7/06 , C07K7/08 , C07K7/56 , C07K14/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K7/52
CPC分类号： C07K14/001 , B65H3/063 , C07K14/47 , C07K14/78 , A61K38/00 , B65H2406/30
摘要： Novel synthetic Arg-Gly-Asp-containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occuring amino acid, or by other methods. In particular, there is provided a cyclic peptide having increased affinity and selectivity for the vitronectin receptor over that of linear, Arg-Gly-Asp-containing synthetic peptides.
摘要翻译： 新型合成的含有Arg-Gly-Asp的合成肽，由于其立体化学构象的限制，对其受体具有高亲和力和特异性。 通过提供另外的化学结构例如天然存在的氨基酸的酰胺或对映异构体或通过其它方法，可以通过环化，包含在约束构象结构如螺旋中来提供这种限制。 特别地，提供了对于丝氨酸蛋白受体的线性，含Arg-Gly-Asp的合成肽具有增加的亲和力和选择性的环肽。
-
公开(公告)号：US5955578A
公开(公告)日：1999-09-21
申请号：US463835
申请日：1995-06-05
IPC分类号： A61K38/00 , A61K31/715 , A61K38/17 , A61K38/39 , A61K47/48 , A61L15/22 , A61L26/00 , A61P3/08 , A61P17/00 , A61P43/00 , C07K1/113 , C07K7/06 , C07K7/08 , C07K9/00 , C07K14/78 , C07K17/02 , C08B37/00 , C12N5/00
CPC分类号： C07K7/08 , A61K38/39 , A61K47/4823 , A61L15/225 , A61L26/0047 , A61L26/0052 , C07K14/78 , C07K7/06 , C08B37/0063 , C12N5/0068 , C12N2533/50 , C12N2533/76 , C12N2533/80
摘要： A conjugate of a synthetic polypeptide containing RGD or (dR) GD and a biodegradable polymer, such as hyaluronic acid or chondroitin sulfate is disclosed. Methods of making the conjugate and using it to aid wound healing by providing a temporary matrix are disclosed.
摘要翻译： 公开了含有RGD或（dR）GD和可生物降解的聚合物如透明质酸或硫酸软骨素的共轭物。 公开了制备缀合物并通过提供临时基质将其用于帮助伤口愈合的方法。
-
公开(公告)号：US5540933A
公开(公告)日：1996-07-30
申请号：US56815
申请日：1993-04-29
IPC分类号： C07K14/705 , A61K9/127 , A61K38/16
CPC分类号： C07K14/705
摘要： Method for the isolation and characterization of a 140,000 dalton cell surface glycoprotein with the properties expected of a fibronectin receptor is described.
摘要翻译： 描述了具有纤连蛋白受体预期特性的140,000道尔顿细胞表面糖蛋白的分离和表征方法。
-
公开(公告)号：US5206347A
公开(公告)日：1993-04-27
申请号：US553355
申请日：1990-07-13
摘要： A method of isolating cell surface receptors utilizing a short peptide sequence bound to an affinity column. Cell surface receptors which bind selectively to the short peptide and which are specific to various adhesion proteins may be isolated therewith from various cell preparations. These receptors, whose functional integrity has been maintained by the presence of the peptide ligand, are incorporated into liposomes and used to deliver specific compounds inside the liposomes to select tissues containing the specific adhesion proteins.
摘要翻译： 利用与亲和柱结合的短肽序列分离细胞表面受体的方法。 可以从各种细胞制剂中分离出选择性结合短肽并且对各种粘附蛋白特异的细胞表面受体。 通过肽配体的存在维持其功能完整性的这些受体并入脂质体中，并用于递送脂质体内的特定化合物以选择含有特异性粘附蛋白的组织。
-
公开(公告)号：US4988621A
公开(公告)日：1991-01-29
申请号：US131130
申请日：1987-12-10
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2539/10
摘要： A method of using synthetic cell attachment-promoting peptides from fibronectin to detach cultured cells from the substratum is described.
摘要翻译： 描述了使用来自纤连蛋白的合成细胞附着促进肽从底物分离培养的细胞的方法。
-
公开(公告)号：US4879237A
公开(公告)日：1989-11-07
申请号：US738078
申请日：1985-05-24
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2539/10
摘要： A method of using synthetic cell attachment-promoting peptides from fibronectin to detach cultured cells from the substratum is described.
摘要翻译： 描述了使用来自纤连蛋白的合成细胞附着促进肽从底物分离培养的细胞的方法。
-
40.发明授权Vitronectin specific cell receptor derived from mammalian mesenchymal tissue 失效来自哺乳动物间充质组织的Vitronectin特异性细胞受体
公开(公告)号：US4789734A
公开(公告)日：1988-12-06
申请号：US763046
申请日：1985-08-06
CPC分类号： A61K9/127 , A61K9/1271 , C07K14/70546 , Y10S530/84 , Y10S530/841 , Y10S530/842
摘要： A method of isolating cell surface receptors utilizing a short peptide sequence bound to an affinity column. Cell surface receptors which bind selectively to the short peptide and which are specific to various adhesion proteins may be isolated therewith from various cell preparations. These receptors, whose functional integrity has been maintained by the presence of the peptide ligand, are incorporated into liposomes and used to deliver specific compounds inside the liposomes to select tissues containing the specific adhesion proteins.
摘要翻译： 利用与亲和柱结合的短肽序列分离细胞表面受体的方法。 可以从各种细胞制剂中分离出选择性结合短肽并且对各种粘附蛋白特异的细胞表面受体。 通过肽配体的存在维持其功能完整性的这些受体并入脂质体中，并用于递送脂质体内的特定化合物以选择含有特异性粘附蛋白的组织。
-
-
-
-
-
-
-
-
-
搜索结果
40 条记录 (耗时 0.033 秒)
