公开(公告)号：US20110253903A1

公开(公告)日：2011-10-20

申请号：US13141864

申请日：2009-12-29

Applicant: Wenjian Sun ,  Xiaohui Yang ,  Li Ding

Inventor： Wenjian Sun ,  Xiaohui Yang ,  Li Ding

IPC: H01J27/08

CPC classification number: H01J49/168

Abstract: The current invention involves a desorption corona beam ionization source/device for analyzing samples under atmospheric pressure without sample pretreatment. It includes a gas source, a gas flow tube, a gas flow heater, a metal tube, a DC power supply and a sample support/holder for placing the samples. A visible corona beam is formed at a sharply pointed tip at the exit of the metal tube when a stream of inert gas flows through the metal tube that is applied with a high DC voltage. The gas is heated for desorbing the analyte from solid samples and the desorbed species are ionized by the energized particles embedded in the corona beam. The ions formed are then transferred through an adjacent inlet into a mass spectrometer or other devices capable of analyzing ions. Visibility of the corona beam in the current invention greatly facilitates pinpointing a sampling area on the analyte and also makes profiling of sample surfaces possible.

Abstract translation: 本发明涉及一种解吸电晕束电离源/装置，用于在大气压力下分析样品而无需样品预处理。 其包括气体源，气体流管，气流加热器，金属管，直流电源和用于放置样品的样品支撑/保持器。 当惰性气体流过施加有高直流电压的金属管时，在金属管的出口处的尖锐尖端处形成可见的电晕束。 加热气体以从固体样品中解吸分析物，并且解吸物质被嵌入电晕束中的通电颗粒电离。 所形成的离子然后通过相邻入口转移到质谱仪或其他能够分析离子的装置中。 本发明中电晕束的可见性大大有助于精确分析分析物上的采样区域，并且还使得样品表面的轮廓成为可能。

公开(公告)号：US20110240845A1

公开(公告)日：2011-10-06

申请号：US13140346

申请日：2009-12-22

Applicant: Li Ding

Inventor： Li Ding

IPC: H01J49/40

CPC classification number: H01J49/027 ,  H01J49/0036 ,  H01J49/4245

Abstract: A mass spectrometric analyzer and an analysis method based on the detection of ion image current are provided. The method in one embodiment includes using electrostatic reflectors or electrostatic deflectors to enable pulsed ions to move periodically for multiple times in the analyzer, forming time focusing in a portion of the ion flight region thereof, and forming an confined ion beam in space; enabling the ion beam to pass through multiple tubular image current detectors arranged in series along an axial direction of the ion beam periodically, using a low-noise electronic amplification device to detect image currents picked up by the multiple tubular detectors differentially, and using a data conversion method, such as a least square regression, to acquire a mass spectrum.

Abstract translation: 提供了基于离子图像电流检测的质谱分析仪和分析方法。 在一个实施例中的方法包括使用静电反射器或静电偏转器使得脉冲离子能够在分析器中周期性移动多次，形成时间聚焦在其离子飞行区域的一部分中，并在空间中形成约束离子束; 使得离子束能够通过使用低噪声电子放大装置周期性地沿着离子束的轴向方向串联布置的多个管状图像电流检测器，以差分地检测由多个管状检测器拾取的图像电流，并使用数据 转换方法，如最小二乘回归，以获得质谱。

公开(公告)号：US07993677B2

公开(公告)日：2011-08-09

申请号：US10722968

申请日：2003-11-26

Applicant: Li Ding ,  Stephanie Morar ,  David Schlossman

Inventor： Li Ding ,  Stephanie Morar ,  David Schlossman

IPC: A61K9/14 ,  A61K9/50 ,  A61K9/56

CPC classification number: A61Q5/02 ,  A61K8/0283 ,  A61K8/8152 ,  A61K9/0014 ,  A61K2800/56 ,  A61Q19/00

Abstract: Stable and uniform distribution of gel beads or other particulate material, dispersed in a liquid medium can be obtained by including a density-reducing agent within the gel beads to provide the particle with a desired bulk density, for example a density close to that of the disperse liquid medium. Suitable density control can prevent migration due to gravity leading to settling in storage. Gel beads formulated with agar are suitable for use in cosmetics and for inclusion in cosmetics formulating processes which may employ modestly elevated temperatures. Attractive and novel cosmetics bead suspensions are described. Additional to cosmetics, pharmaceutical, foodstuff and other applications are disclosed. Examples of suitable density-reducing agents include very low density hollow polymeric microspheres and temperature-sensitive expandable thermoplastic microspheres.

Abstract translation: 分散在液体介质中的凝胶珠或其它颗粒材料的稳定和均匀分布可以通过在凝胶珠内包含密度降低剂来提供颗粒以获得所需的堆积密度，例如接近于 分散液体介质。 合适的密度控制可以防止由重力引起的迁移导致储存沉降。 用琼脂配制的凝胶珠适用于化妆品和包含在可能采用温和升高的温度的化妆品配方中。 描述了有吸引力和新颖的化妆品珠悬浮液。 披露了化妆品，制药，食品和其他应用的附加物。 合适的减密剂的实例包括非常低密度的中空聚合物微球和温度敏感的可发性热塑性微球。

公开(公告)号：US07943902B2

公开(公告)日：2011-05-17

申请号：US11916355

申请日：2006-05-26

Applicant: Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

Inventor： Li Ding ,  Alan Joseph Smith ,  Evgenij Nikolaevich Nikolaev

IPC: H01J49/04 ,  H01J49/26

CPC classification number: H01J49/4295 ,  H01J49/0072 ,  H01J49/0095 ,  H01J49/062

Abstract: A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.

Abstract translation: 描述了将离子引入离子阱和离子存储装置的方法。 引入装置用于通过离子阱的入口将第一离子引入离子阱。 引入装置的操作条件被调整以使得与第一离子不同的第二离子通过相同的入口孔引入离子阱。

公开(公告)号：US20090055797A1

公开(公告)日：2009-02-26

申请号：US11844121

申请日：2007-08-23

Applicant: Li Ding ,  Donald J. Yantzi

Inventor： Li Ding ,  Donald J. Yantzi

IPC: G06F9/44

CPC classification number: G06F8/00

Abstract: A method and computer program product of incrementally visualizing graphical extensible models for legacy software applications via a user interface are provided. A graph of nodes and connections showing only the highest level of details are presented. Each node that contains additional, lower level, details is shown with an expansion icon that may be selected to see additional levels of detail for the node. When selected, the user interface drills down to show the next lowest level of details for that artifact within a visual boundary of the original artifact that was expanded. Because of the nested, hierarchical nature of the model, relationships between higher level artifacts can be inferred from explicit relationships between lower level artifacts. When the node is expanded, any connections that previously connected to the higher level artifact are updated to connect to the appropriate artifact in the lower level details.

Abstract translation: 提供了一种通过用户界面逐步可视化传统软件应用程序的图形可扩展模型的方法和计算机程序产品。 提出了仅显示最高级别细节的节点和连接图。 包含附加，较低级别的详细信息的每个节点都会显示一个扩展图标，该图标可能被选择以查看该节点的附加级别的详细信息。 当选择时，用户界面向下钻取，以便在扩展的原始工件的视觉边界内显示该工件的下一个最低级别的细节。 由于模型的嵌套层次性，可以从较低级别的工件之间的显式关系推断出较高级的工件之间的关系。 当节点扩展时，先前连接到较高级别工件的任何连接都将被更新，以连接到较低级别详细信息中的相应工件。

公开(公告)号：US20080300147A1

公开(公告)日：2008-12-04

申请号：US10590675

申请日：2005-03-28

Applicant: Nasser Chegini ,  Xiaoping Luo ,  Li Ding ,  R. Stan Williams

Inventor： Nasser Chegini ,  Xiaoping Luo ,  Li Ding ,  R. Stan Williams

IPC: C40B40/06 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/364

Abstract: The present invention provides a method for detecting a fibrotic disorder in a subject by: (a) providing a biological sample obtained from the subject (such as endometrium, peritoneal fluid, and/or smooth muscle cells); (b) analyzing the expression of at least one gene that is differentially expressed in the fibrotic disorder of interest; and (c) correlating the expression of the gene(s) with the presence or absence of the fibrotic disorder in the subject. The present invention also provides a method and compositions for modulating the expression of genes that are differentially expressed in fibrotic tissues, compared to normal tissues. Restoration of gene expression to levels associated with normal tissue is expected to ameliorate at least some of the symptoms of the fibrotic disorder. This method includes the step of contacting the tissue with an agent that modulates expression of one or more differentially expressed genes in the tissue. The present invention also includes arrays, such as microfluidic cards, for detecting differential gene expression in samples of fibrotic tissue.

Abstract translation: 本发明提供一种通过以下方法检测受试者中的纤维化病症的方法：（a）提供从受试者获得的生物样品（例如子宫内膜，腹膜液和/或平滑肌细胞）; （b）分析在感兴趣的纤维化疾病中差异表达的至少一种基因的表达; 和（c）将基因的表达与受试者中是否存在纤维化病症相关联。 本发明还提供了与正常组织相比调节在纤维组织中差异表达的基因表达的方法和组合物。 将基因表达恢复到与正常组织相关的水平，预期可以改善纤维化病症的至少一些症状。 该方法包括使组织与调节组织中一种或多种差异表达基因的表达的试剂接触的步骤。 本发明还包括用于检测纤维组织样品中差异基因表达的阵列，例如微流控卡。

公开(公告)号：US07326924B2

公开(公告)日：2008-02-05

申请号：US10558474

申请日：2004-06-02

Applicant: Li Ding ,  Francesco Lorenzo Brancia

Inventor： Li Ding ,  Francesco Lorenzo Brancia

IPC: H01J49/42 ,  H01J49/00 ,  B01D59/44

CPC classification number: H01J49/424 ,  H01J49/429

Abstract: A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.

Abstract translation: 使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比 其具有接近感兴趣的离子的质荷比的下限。 确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。

公开(公告)号：US07272807B2

公开(公告)日：2007-09-18

申请号：US11071121

申请日：2005-03-02

Applicant: Li Ding ,  Peivand Fallah Tehrani ,  Alireza Kasnavi

Inventor： Li Ding ,  Peivand Fallah Tehrani ,  Alireza Kasnavi

IPC: G06F17/50

CPC classification number: G06F17/5036 ,  G06F17/5031

Abstract: An equivalent waveform for a distorted waveform used in timing and signal integrity analysis in the design of an integrated circuit is automatically generated. The equivalent waveform is produced by calculating the transition quantity of a first non-distorted waveform. The transition quantity is the amount of transition of the first non-distorted waveform that is required for the cell to produce an output waveform with a predetermined end voltage. The end point of the transition period for the distorted waveform is then determined based on when the distorted waveform has accumulated the same transition quantity. The equivalent waveform can then be formed by computing a second non-distorted waveform such that the end point of the transition period for the second non-distorted waveform coincides with the end point of the transition period for the distorted waveform.

Abstract translation: 自动生成在集成电路设计中用于定时和信号完整性分析的失真波形的等效波形。 通过计算第一非失真波形的转移量来产生等效波形。 转换量是单元格产生具有预定端电压的输出波形所需的第一非失真波形的转变量。 然后，基于失真波形累积相同过渡量的时间来确定失真波形的转换周期的终点。 然后可以通过计算第二非失真波形来形成等效波形，使得第二非失真波形的转换周期的终点与失真波形的过渡周期的终点重合。

公开(公告)号：US20070092885A1

公开(公告)日：2007-04-26

申请号：US11378616

申请日：2006-03-20

Applicant: Henry Yue ,  Monique Yao ,  Ameena Gandhi ,  Mariah Baughn ,  Anita Swarnakar ,  Narinder Chawla ,  Madhusudan Sanjanwala ,  Michael Thornton ,  Vicki Elliott ,  Yan Lu ,  Kimberly Gietzen ,  Neil Burford ,  Li Ding ,  April Hafalia ,  Y. Tang ,  Olga Bandman ,  Bridget Warren ,  Cynthia Honchell ,  Dyung Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti Lal ,  Bao Tran ,  Craig Ison ,  Brendan Duggan ,  Stephanie Sapperstein

Inventor： Henry Yue ,  Monique Yao ,  Ameena Gandhi ,  Mariah Baughn ,  Anita Swarnakar ,  Narinder Chawla ,  Madhusudan Sanjanwala ,  Michael Thornton ,  Vicki Elliott ,  Yan Lu ,  Kimberly Gietzen ,  Neil Burford ,  Li Ding ,  April Hafalia ,  Y. Tang ,  Olga Bandman ,  Bridget Warren ,  Cynthia Honchell ,  Dyung Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti Lal ,  Bao Tran ,  Craig Ison ,  Brendan Duggan ,  Stephanie Sapperstein

IPC: C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C07K14/705

CPC classification number: C12N15/1055 ,  A61K39/3955 ,  A61K47/64 ,  A61K47/643 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/4711 ,  C07K14/4713 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/5023

Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

公开(公告)号：US20070075239A1

公开(公告)日：2007-04-05

申请号：US10558474

申请日：2004-06-02

Applicant: Li Ding ,  Francesco Brancia

Inventor： Li Ding ,  Francesco Brancia

IPC: H01J49/42

CPC classification number: H01J49/424 ,  H01J49/429

Abstract: A method for obtaining high accuracy mass spectra using an ion trap mass analyzer includes adjusting operating parameters of the analyser to enable a reverse mass scan in a mass selective resonance ejection mode and setting the trapping field to trap ions in a mass-to-charge ratio which has a lower limit close to the mass-to-charge ratio of an ion of interest. A method of determining chemical shift includes adjusting operating parameters of the analyzer to enable forward and reverse mass scans and calibrating the spectra obtained from the forward and reverse mass scans.

Abstract translation: 使用离子阱质量分析仪获得高精度质谱的方法包括：调节分析仪的工作参数，使得能够以质量选择共振喷射模式进行反向质谱扫描，并设置捕获场以捕集质荷比 其具有接近感兴趣的离子的质荷比的下限。 确定化学位移的方法包括调整分析仪的操作参数，以进行正向和反向质量扫描并校准从正向和反向质量扫描获得的光谱。